2.3.1.47 (R)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine 8.6% product is formed matching the portion of S-enantiomer substrate (9.3%),37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, 1 mM S-adenosyl-L-methionine, 10 microM (R)-8-amino-7-oxononanoic acid Mycobacterium tuberculosis (7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid) - ? 407647 2.3.1.47 (S)-8-amino-7-oxononanoic acid + (R)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine 46.3% product is formed from the racemic substrate, 37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, 1 mM S-adenosyl-L-methionine, 2 microM racemic 8-amino-7-oxononanoic acid Mycobacterium tuberculosis (7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid) - ? 407677 2.3.1.47 (S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine 37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, 1 mM S-adenosyl-L-methionine, 2 microM (S)-8-amino-7-oxononanoic acid Mycobacterium tuberculosis (7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid) - ? 406980 2.3.1.47 (S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine 37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, varying S-adenosyl-L-methionine, 9 microM (S)-8-amino-7-oxononanoic acid, varying inhibitor concentration Escherichia coli (7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid) - ? 406980 2.3.1.47 (S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine 93.2% product is formed matching the portion of S-enantiomer substrate (94.6%), 37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, 1 mM S-adenosyl-L-methionine, 2 microM (S)-8-amino-7-oxononanoic acid Mycobacterium tuberculosis (7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid) - ? 406980 2.3.1.47 (S)-8-amino-7-oxononanoic acid + S-adenosyl-L-methionine 37°C, direct assay with 100 mM N-(2-hydroxyethyl)piperazine-N'-(2-propanesulfonic acid) buffer (pH 8.6), 0.1 mM pyridoxal 5'-phosphate, varying S-adenosyl-L-methionine, 9 microM (S)-8-amino-7-oxononanoic acid, varying inhibitor concentration Escherichia coli C268 (7R,8S)-diaminopelargonic acid + S-adenosyl-(4-methylthio-2-oxobutanoic acid) - ? 406980 2.3.1.47 6-carboxyhexanoyl-CoA + D-alanine the L-isomer of the amino acid is preferred, D-alanine shows 5fold slower reaction, interaction analysis, overview Mycobacterium tuberculosis 8-amino-7-oxononanoate + CoA + CO2 i.e. D-KAPA ? 387629 2.3.1.47 6-carboxyhexanoyl-CoA + L-alanine - Escherichia coli 8-amino-7-oxononanoate + CoA + CO2 - ? 320929 2.3.1.47 6-carboxyhexanoyl-CoA + L-alanine absolutely specific for L-alanine Lysinibacillus sphaericus 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ? 320929 2.3.1.47 6-carboxyhexanoyl-CoA + L-alanine i.e. pimeloyl-CoA Alcaligenes faecalis 8-amino-7-oxononanoate + CoA + CO2 i.e. 7-oxo-8-amino-pelargonic acid ? 320929