2.3.1.219 (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O preferred activity of CURS3 Curcuma longa bisdemethoxycurcumin + 2 CO2 + CoA - ? 421741 2.3.1.219 (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O - Curcuma longa bisdemethoxycurcumin + CO2 + CoA - ? 421742 2.3.1.219 (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O - Curcuma longa demethoxycurcumin + CO2 + CoA - ? 421744 2.3.1.219 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O curcumin synthase (ZoCURS), in the presence of diketide-CoA synthase, can accept p-coumaroyl-CoA to produce bidemethoxycurcumin Zingiber officinale 2 CoA + bidemethoxycurcumin + CO2 - ? 455041 2.3.1.219 4-coumaroyl-CoA + cinnamoyl-diketide-N-acetylcysteamine + H2O - Curcuma longa CoA + cinnamoyl-4-coumaroylmethane + N-acetylcysteamine - ? 422580 2.3.1.219 4-coumaroyl-CoA + feruloylacetyl-CoA - Curcuma longa demethoxycurcumin + CO2 + CoA - ? 421809 2.3.1.219 4-coumaroyl-CoA + feruloylacetyl-CoA preferred activity of CURS3 Curcuma longa demethoxycurcumin + CO2 + CoA - ? 421809 2.3.1.219 cinnamoyl-CoA + cinnamoyl-acetyl-CoA + H2O curcumin synthase (ZoCURS), in the presence of diketide-CoA synthase, can accept cinnamoyl-CoA to produce dicinnamoylmethane Zingiber officinale 2 CoA + dicinnamoylmethane + CO2 - ? 455465 2.3.1.219 cinnamoyl-CoA + cinnamoyl-diketide-N-acetylcysteamine + H2O low activity Curcuma longa CoA + dicinnamoylmethane + N-acetylcysteamine - ? 423125 2.3.1.219 additional information substrate specificity, overview. CURS2 prefers feruloyl-CoA as a starter substrate, cf. EC 2.3.1.217, while CURS3 is equally active with both feruloyl-CoA and 4-coumaroyl-CoA. Thus, CURS2 synthesizes curcumin or demethoxycurcumin and CURS3 synthesizes curcumin, bisdemethoxycurcumin and demethoxycurcumin Curcuma longa ? - ? 89