1.14.99.1 (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid + AH2 + O2 - Ovis aries ? + A + H2O - ? 415902 1.14.99.1 (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid + AH2 + O2 - Salvelinus fontinalis ? + A + H2O - ? 415902 1.14.99.1 (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoic acid + AH2 + O2 the substrate is bound in the cyclooxygenase channel of COX-2, binding structure, overview. The carboxylate of docosahexaenoate interacts with Arg120 and Tyr355 at the base of the channel and the omega-end abuts the side chain of Ile377 near Gly533 in the hydrophobic groove above Ser530 Mus musculus ? + A + H2O - ? 415902 1.14.99.1 (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid + AH2 + O2 substrate binding structure and nonproductive conformation, overview Mus musculus ? + A + H2O - ? 415907 1.14.99.1 8,11,14-eicosatrienoic acid + O2 - Bos taurus prostaglandin G1 + ? - ? 287971 1.14.99.1 8,11,14-eicosatrienoic acid + O2 bis-dioxygenase activity, cyclooxygenase activity, presence of hematin Bos taurus prostaglandin G1 + ? 9alpha,11alpha-epidioxy-15(S)-hydroperoxy-13-trans-prostenoic acid ? 287971 1.14.99.1 8,11,14-eicosatrienoic acid + O2 - Bos taurus prostaglandin H1 + ? - ? 287972 1.14.99.1 8,11,14-eicosatrienoic acid + O2 hydroperoxidase activity, presence of hematin and tryptophan Bos taurus prostaglandin H1 + ? - ? 287972 1.14.99.1 alpha-linolenic acid + reduced acceptor + O2 - Ovis aries ? - r 451382 1.14.99.1 alpha-linolenic acid + reduced acceptor + O2 - Salvelinus fontinalis ? - r 451382