1.14.11.8 additional information enzyme is localized to the mitochondrial matrix, product formation is limited by 6-N-trimethyllysine transport across the mitochondrial inner membrane Rattus norvegicus ? - ? 89 1.14.11.8 additional information determination of the (2S,3S)-3-hydroxy-N6,N6,N6-trimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine is performed by ultraperformance liquid chromatography–tandem mass spectrometry (UPLC/MS/MS) in positive ion electrospray mode Homo sapiens ? - ? 89 1.14.11.8 additional information NMR spectrosopic structure analysis of substrates and products Homo sapiens ? - ? 89 1.14.11.8 additional information NMR spectrosopic structure analysis of substrates and products, substrate specificity, overview. No or poor activity with dimethyllysine, methyllysine, lysine, D-trimethyllysine, 5-trimethylamino-1-aminopentane, trimethyllysine, 6-trimethylaminohexanoic acid, hexamethyllysine, N-acetyltrimethyllysine, trimethyldiaminobutyric acid, triethyllysine, symmetric and asymmetric dimethylarginines, mildronate, and gamma-butyrobetaine, structure-activity relationship study Homo sapiens ? - ? 89 1.14.11.8 N5,N5,N5-trimethyl-L-ornithine + 2-oxoglutarate + O2 - Homo sapiens (3S)-3-hydroxy-N5,N5,N5-trimethyl-L-ornithine + succinate + CO2 - ? 443777 1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 - Mus musculus 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 - ? 2718 1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 - Homo sapiens 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 - ? 2718 1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 - Rattus norvegicus 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 - ? 2718 1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 - Sus scrofa 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 - ? 2718 1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 - Neurospora crassa 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 - ? 2718