1.1.1.324 (6E)-8-hydroxygeraniol + 2 NADP+ - Rauvolfia serpentina (6E)-8-oxogeranial + 2 NADPH + 2 H+ - r 417824 1.1.1.324 (6E)-8-hydroxygeraniol + 2 NADP+ - Nepeta racemosa (6E)-8-oxogeranial + 2 NADPH + 2 H+ - ? 417824 1.1.1.324 (6E)-8-hydroxygeraniol + 2 NADP+ 10-hydroxygeraniol undergoes a reversible dehydrogenation to produce 8-oxogeraniol or 8-hydroxygeranial, which are oxidized further to give 8-oxogeranial, the direct precursor of iridodial Rauvolfia serpentina (6E)-8-oxogeranial + 2 NADPH + 2 H+ - r 417824 1.1.1.324 (6E)-8-hydroxygeraniol + 2 NADP+ oxidization at C1 and C8, depending on numbering of the molecule, GC-MS product analysis Nepeta racemosa (6E)-8-oxogeranial + 2 NADPH + 2 H+ - ? 417824 1.1.1.324 (6E)-8-hydroxynerol + 2 NADP+ - Rauvolfia serpentina ? + 2 NADPH + 2 H+ - r 417825 1.1.1.324 (6E)-8-hydroxynerol + 2 NADP+ - Nepeta racemosa ? + 2 NADPH + 2 H+ - ? 417825 1.1.1.324 (6E)-8-hydroxynerol + 2 NADP+ oxidization at C1 and C8, depending on numbering of the molecule, GC-MS product analysis Nepeta racemosa ? + 2 NADPH + 2 H+ - ? 417825 1.1.1.324 geraniol + 2 NADP+ - Rauvolfia serpentina ? + 2 NADPH + 2 H+ - r 418645 1.1.1.324 additional information various branched-chain allylic primary alcohols, such as nerol, geraniol, and 8-hydroxygeraniol, are substrates, but ethanol is inert. The enzyme is also active with farnesol, 3-methyl-2-buten1-ol, citronellol, 4-isopropylbenzyl alcohol, trans-2-heptenol, and trans-2-hexenol. The enzyme exclusively transfers the pro-R hydrogen of NADPH to neral. No activity with linalool, 2,6-dimethyl-octane, iridodial, 1-octanol, 1-heptanol, 1-pentanol, 3-methyl-3-buten-1-ol, trans-crotyl alcohol, isopulegol, and menthol Rauvolfia serpentina ? - ? 89 1.1.1.324 nerol + 2 NADP+ - Rauvolfia serpentina ? + 2 NADPH + 2 H+ - r 418943