6.3.4.2	ATP + UTP + L-glutamine	-	Anoxybacillus gonensis	ADP + phosphate + CTP + L-glutamate	-	?	398811	
6.3.4.2	ATP + UTP + L-glutamine	-	Anoxybacillus gonensis G2	ADP + phosphate + CTP + L-glutamate	-	?	398811	
6.3.4.2	ATP + UTP + NH4+	-	Bacillus subtilis	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	additional information	repression of the pyrG gene encoding cytidine triphosphate synthetase is responsive to cytidine nucleotide levels and is independent of both uridine nucleotides and PyrR-dependent attenuation	Bacillus subtilis	?	-	?	89	
6.3.4.2	ATP + UTP + glutamine	-	Bos taurus	ADP + phosphate + CTP + Glu	-	?	363677	
6.3.4.2	ATP + UTP + NH4+	-	Bos taurus	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	GTP + UTP + NH4+	-	Bos taurus	GDP + phosphate + CTP	-	?	363676	
6.3.4.2	ATP + UTP + NH4+	-	Chlamydia trachomatis	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + NH4+	-	Chlamydia trachomatis L2/CPEC	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + L-glutamine	-	Drosophila melanogaster	ADP + phosphate + CTP + L-glutamate	-	?	398811	
6.3.4.2	ATP + UTP + gamma-L-glutamylhydroxamate	-	Escherichia coli	ADP + phosphate + N4-hydroxy-CTP	-	?	379508	
6.3.4.2	ATP + UTP + Gln	-	Escherichia coli	ADP + phosphate + CTP + Glu	-	?	379509	
6.3.4.2	ATP + UTP + Gln + H2O	-	Escherichia coli	ADP + CTP + Glu + phosphate	-	?	388162	
6.3.4.2	ATP + UTP + glutamine	-	Escherichia coli	ADP + phosphate + CTP + Glu	-	?	363677	
6.3.4.2	ATP + UTP + glutamine	maximal activity with NH4+ is at least 20% greater than with glutamine	Escherichia coli	ADP + phosphate + CTP + Glu	-	?	363677	
6.3.4.2	ATP + UTP + L-gamma-glutamyl hydrazide	-	Escherichia coli	ADP + phosphate + N4-amino-CTP + L-glutamate	-	?	379507	
6.3.4.2	ATP + UTP + L-glutamine	-	Escherichia coli	ADP + phosphate + CTP + L-glutamate	-	?	398811	
6.3.4.2	ATP + UTP + L-glutamine	CTPS catalyses the ATP-dependent formation of CTP from UTP using either ammonia or L-glutamine as the nitrogen source	Escherichia coli	ADP + phosphate + CTP + L-glutamate	-	?	398811	
6.3.4.2	ATP + UTP + NH2NH2	-	Escherichia coli	ADP + phosphate + CTP + N4-amino CTP	-	?	379511	
6.3.4.2	ATP + UTP + NH2OH	-	Escherichia coli	ADP + phosphate + N4-hydroxy-CTP	-	?	379512	
6.3.4.2	ATP + UTP + NH3	-	Escherichia coli	ADP + CTP + phosphate	-	?	388164	
6.3.4.2	ATP + UTP + NH3	-	Escherichia coli	ADP + phosphate + CTP	-	?	398812	
6.3.4.2	ATP + UTP + NH3	CTPS catalyses the ATP-dependent formation of CTP from UTP using either ammonia or L-glutamine as the nitrogen source	Escherichia coli	ADP + phosphate + CTP	-	?	398812	
6.3.4.2	ATP + UTP + NH4+	-	Escherichia coli	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + NH4+	-	Escherichia coli	ADP + phosphate + CTP	-	ir	363669	
6.3.4.2	deoxyGTP + UTP + NH4+	-	Escherichia coli	deoxyGDP + phosphate + CTP	-	?	363675	
6.3.4.2	GTP + UTP + NH4+	-	Escherichia coli	GDP + phosphate + CTP	-	?	363676	
6.3.4.2	L-glutamine + H2O	-	Escherichia coli	L-glutamate + NH3	-	?	116389	
6.3.4.2	additional information	CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP	Escherichia coli	?	-	?	89	
6.3.4.2	additional information	UTP- and CTP-binding structures, overview	Escherichia coli	?	-	?	89	
6.3.4.2	UTP + ATP + NH3	the enzyme is regulated in a complex fashion, overview	Escherichia coli	CTP + ADP + phosphate	-	?	407452	
6.3.4.2	UTP + ATP + NH3	NH3 from glutamine deamination or exogenous	Escherichia coli	CTP + ADP + phosphate	-	?	407452	
6.3.4.2	ATP + UTP + glutamine	maximal activity with NH4+ is at least 20% greater than with glutamine	Escherichia coli B / ATCC 11303	ADP + phosphate + CTP + Glu	-	?	363677	
6.3.4.2	ATP + UTP + NH4+	-	Escherichia coli B / ATCC 11303	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + Gln + H2O	-	Homo sapiens	ADP + CTP + Glu + phosphate	-	?	388162	
6.3.4.2	ATP + UTP + glutamine	-	Homo sapiens	ADP + phosphate + CTP + L-glutamate	-	?	398810	
6.3.4.2	ATP + UTP + glutamine	the CTPS1-encoded enzyme is regulated by reversible phosphorylation at Thr455, regulation mechanisms, overview	Homo sapiens	ADP + phosphate + CTP + L-glutamate	-	?	398810	
6.3.4.2	ATP + UTP + L-Gln	-	Homo sapiens	ADP + phosphate + CTP + L-Glu	-	?	416660	
6.3.4.2	ATP + UTP + NH3	-	Homo sapiens	ADP + phosphate + CTP	-	?	398812	
6.3.4.2	ATP + UTP + NH3	CTPS1 is involved in microtubule network formation and/or stabilzation, overview	Homo sapiens	ADP + phosphate + CTP	-	?	398812	
6.3.4.2	ATP + UTP + NH4+	-	Homo sapiens	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	additional information	key enzyme for biosynthesis of cytosine ribonucleotides	Homo sapiens	?	-	?	89	
6.3.4.2	additional information	the enzyme catalyzes the rate-limiting step in synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways	Homo sapiens	?	-	?	89	
6.3.4.2	additional information	rate-limiting enzyme in the synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways. In human lymphoblastic leukemia cells the synthesis of CTP occurs predominantly via CTP synthetase, whereas in proliferating normal human T lymphocytes the salvage of cytidine is preferred	Homo sapiens	?	-	?	89	
6.3.4.2	additional information	the enzyme is one of the key enzymes in pyrimidine nucleotide anabolic pathways. The activity of this enzyme is elevated in various malignancies including acute lymphocytic leukemia	Homo sapiens	?	-	?	89	
6.3.4.2	additional information	CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP	Homo sapiens	?	-	?	89	
6.3.4.2	additional information	CTPS1 interacts with the GST-tagged peptidyl prolyl isomerase Pin1 from Xenopus laevis in a Ser575 phosphorylation-dependent manner, the CTPS1 also binds several other enzyme, e.g. alpha-tubulin, overview	Homo sapiens	?	-	?	89	
6.3.4.2	ATP + dUTP + NH4+	half-saturating concentration of 0.6 mM for dUTP, it is unlikely that this reaction plays a significant physiological role	Lactococcus lactis	ADP + phosphate + dCTP	-	?	363678	
6.3.4.2	ATP + UTP + Gln	-	Lactococcus lactis	ADP + phosphate + CTP + Glu	-	?	379509	
6.3.4.2	ATP + UTP + glutamine	-	Lactococcus lactis	ADP + phosphate + CTP + Glu	-	?	363677	
6.3.4.2	ATP + UTP + hydroxylamine	-	Lactococcus lactis	ADP + phosphate + N4-OH-CTP	-	?	379510	
6.3.4.2	ATP + UTP + NH4+	-	Lactococcus lactis	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	additional information	CTP limitation increases expression of CTP synthase in Lactococcus lactis. At normal CTP concentrations a terminator is preferentially formed in the pyrG leader, thereby reducing expression of CTP synthase. At low CTP concentrations the RNA polymerase pauses at a stretch of C residues inthe pyrG leader, thereby allowing an antiterminator to form and transcription to proceed	Lactococcus lactis	?	-	?	89	
6.3.4.2	additional information	in Lactococcus lactis the pyrG gene product is the only enzyme responsible for the amination of UTP to CTP	Lactococcus lactis	?	-	?	89	
6.3.4.2	ATP + UTP + CH3NHOH	-	Mus musculus	ADP + phosphate + ?	-	?	363672	
6.3.4.2	ATP + UTP + glutamine	-	Mus musculus	ADP + phosphate + CTP + Glu	-	?	363677	
6.3.4.2	ATP + UTP + hydroxylamine	activity is about 3fold higher than activity with NH4+	Mus musculus	ADP + phosphate + N4-hydroxyCTP	-	?	363670	
6.3.4.2	ATP + UTP + NH2NH2	-	Mus musculus	ADP + phosphate + ?	-	?	363673	
6.3.4.2	ATP + UTP + NH4+	-	Mus musculus	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + O-methylhydroxylamine	-	Mus musculus	ADP + phosphate + N4-methoxyCTP	-	?	363671	
6.3.4.2	deoxyATP + UTP + NH4+	-	Mus musculus	deoxyADP + phosphate + CTP	-	?	363674	
6.3.4.2	deoxyGTP + UTP + NH4+	-	Mus musculus	deoxyGDP + phosphate + CTP	-	?	363675	
6.3.4.2	GTP + UTP + NH4+	-	Mus musculus	GDP + phosphate + CTP	-	?	363676	
6.3.4.2	additional information	CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP	Mus musculus	?	-	?	89	
6.3.4.2	ATP + UTP + NH4+	-	Rattus norvegicus	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	GTP + UTP + NH4+	-	Rattus norvegicus	GDP + phosphate + CTP	-	?	363676	
6.3.4.2	L-glutamine + H2O	-	Rattus norvegicus	L-glutamate + NH3	-	?	116389	
6.3.4.2	ATP + dUTP + NH4+	-	Saccharomyces cerevisiae	ADP + phosphate + dCTP	-	?	363678	
6.3.4.2	ATP + UTP + glutamine	-	Saccharomyces cerevisiae	ADP + phosphate + CTP + Glu	-	?	363677	
6.3.4.2	ATP + UTP + glutamine	-	Saccharomyces cerevisiae	ADP + phosphate + CTP + L-glutamate	-	?	398810	
6.3.4.2	ATP + UTP + glutamine	CTP synthetase is a cytosolic-associated glutamine amidotransferase enzyme that catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to the C-4 position of UTP to form CTP. CTP is an essential precursor of all membrane phospholipids that are synthesized via the Kennedy, i.e. CDP-choline and CDP-ethanolamine branches, and CDP-diacylglycerol pathways. The URA7-encoded CTP synthetase is responsible for the majority of the CTP made in vivo. Regulation mechanisms, detailed overview	Saccharomyces cerevisiae	ADP + phosphate + CTP + L-glutamate	-	?	398810	
6.3.4.2	ATP + UTP + NH4+	-	Saccharomyces cerevisiae	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	additional information	CTP synthetase plays a pivotal role in the synthesis of CTP and dCTP	Saccharomyces cerevisiae	?	-	?	89	
6.3.4.2	additional information	regulation of CTP synthetase activity by CTP plays an important role in the regulation of phospholipid synthesis	Saccharomyces cerevisiae	?	-	?	89	
6.3.4.2	additional information	the enzyme is allosterically regulated by CTP product inhibition and by reversible phosphorylation	Saccharomyces cerevisiae	?	-	?	89	
6.3.4.2	ATP + UTP + NH4+	-	Thermus thermophilus	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + NH4+	-	Thermus thermophilus HB8	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + NH4+	last step in CTP biosynthesis	Thermus thermophilus HB8	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + NH4+	-	Thermus thermophilus HB8 / ATCC 27634 / DSM 579	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	ATP + UTP + Gln + H2O	-	Trypanosoma brucei	ADP + CTP + Glu + phosphate	-	?	388162	
6.3.4.2	ATP + UTP + L-glutamine	-	Trypanosoma brucei	ADP + phosphate + CTP + L-glutamate	-	ir	398811	
6.3.4.2	ATP + UTP + NH4+	-	Trypanosoma brucei	ADP + phosphate + CTP	-	?	363669	
6.3.4.2	GTP + UTP + NH4+	-	Trypanosoma brucei	GDP + phosphate + CTP	-	?	363676	
6.3.4.2	additional information	the enzyme can utilize NH3 as a substrate	Trypanosoma brucei	?	-	?	89