6.3.2.26	3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O	-	Penicillium chrysogenum	3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine	-	?	427297	
6.3.2.26	3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O	-	Penicillium chrysogenum Wisconsin 54-1255	3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine	-	?	427297	
6.3.2.26	6-oxopiperidine 2-carboxylic acid + L-cysteine + L-valine + ATP	-	Amycolatopsis lactamdurans	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289204	
6.3.2.26	alpha-aminoadipic acid + L-valine + L-lysine + ?	enzyme is a nonribosomal peptide synthetase (NRPS) able to form ribosome-independent peptide bonds	Actinomyces sp.	L-delta-alpha-aminoadipyl-L-cysteinyl-D-valine + ?	ACV	?	402415	
6.3.2.26	ATP + (R)-4-phosphopantoate + beta-alanine	the enzyme is involved in coenzyme A biosynthesis in the archaea	Thermococcus kodakarensis	AMP + diphosphate + (R)-4'-phosphopantothenate	-	?	427357	
6.3.2.26	ATP + (R)-4-phosphopantoate + beta-alanine	strict preference for ATP. Among several amine substrates, activity is detected with beta-alanine, but not with gamma-aminobutyrate, glycine nor aspartate	Thermococcus kodakarensis	AMP + diphosphate + (R)-4'-phosphopantothenate	-	?	427357	
6.3.2.26	DL-valine + L-O-(methylserine) + L-2-aminohexanedioate + ATP	-	Acremonium chrysogenum	L-O-(methylserinyl)-D-valine + L-O-(methylserinyl)-D-valine + AMP + diphosphate	-	?	289200	
6.3.2.26	L-2-aminoadipate + allylglycine + L-valine + ATP	-	Acremonium chrysogenum	L-delta-(aminoadipyl)-L-allylglycinyl-D-valine + AMP + diphosphate	-	?	289197	
6.3.2.26	L-2-aminoadipate + allylglycine + L-valine + ATP	-	Streptomyces clavuligerus	L-delta-(aminoadipyl)-L-allylglycinyl-D-valine + AMP + diphosphate	-	?	289197	
6.3.2.26	L-2-aminoadipate + L-cystathionine + L-valine + ATP	-	Amycolatopsis lactamdurans	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289205	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-allo-isoleucine + ATP	-	Acremonium chrysogenum	L-delta-(aminoadipyl)-L-cysteinyl-D-allo-isoleucine + AMP + diphosphate	-	?	289199	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-allo-isoleucine + ATP	-	Streptomyces clavuligerus	L-delta-(aminoadipyl)-L-cysteinyl-D-allo-isoleucine + AMP + diphosphate	-	?	289199	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-isoleucine + ATP	-	Streptomyces clavuligerus	L-delta-(aminoadipyl)-L-cysteinyl-D-isoleucine + AMP + diphosphate	-	?	289202	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Aspergillus nidulans	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289195	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Penicillium chrysogenum	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289195	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Amycolatopsis lactamdurans	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289195	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Acremonium chrysogenum	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289195	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Acremonium persicinum	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289195	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Streptomyces clavuligerus	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289195	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Streptomyces clavuligerus	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	ir	289195	
6.3.2.26	L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Lysobacter lactamgenus	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289195	
6.3.2.26	L-2-aminoadipate + L-homocysteine + L-valine + ATP	-	Streptomyces clavuligerus	N-(5-amino-5-carboxypentanoyl)-L-homocysteinyl-D-valine + AMP + diphosphate	-	?	289203	
6.3.2.26	L-2-aminoadipate + vinylglycine + L-valine + ATP	-	Acremonium chrysogenum	L-delta-(aminoadipyl)-L-vinylglycinyl-D-valine + AMP + diphosphate	-	?	289198	
6.3.2.26	L-2-aminoadipate + vinylglycine + L-valine + ATP	-	Streptomyces clavuligerus	L-delta-(aminoadipyl)-L-vinylglycinyl-D-valine + AMP + diphosphate	-	?	289198	
6.3.2.26	L-glutamate + L-cysteine + L-valine + ATP	-	Streptomyces clavuligerus	L-glutamyl-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289201	
6.3.2.26	additional information	ACVSs are multifunctional enzymes that activate amino acids as aminoacyladenylates, forming a mixed anhydride with the a-phosphate group of ATP and releasing pyrophosphate	Actinomyces sp.	?	-	?	89	
6.3.2.26	additional information	pure Streptomyces lactamdurans ACVS is able to activate alpha-aminoadipic acid or its lactam 6-oxopiperideine-2-carboxylic acid, a compound that is easily converted to alpha-aminoadipic acid, but is unable to use piperideine-6-carboxylate or pipecolic acid as substrates, enzyme is also able to use L-cystathionine with the same efficiency as L-cysteine	Actinomyces sp.	?	-	?	89	
6.3.2.26	S-carboxymethylcysteine + L-cysteine + L-valine + ATP	-	Acremonium chrysogenum	L-S-carboxymethylcysteinyl-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289196	
6.3.2.26	S-carboxymethylcysteine + L-cysteine + L-valine + ATP	-	Streptomyces clavuligerus	L-S-carboxymethylcysteinyl-L-cysteinyl-D-valine + AMP + diphosphate	-	?	289196