4.1.1.33 (3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid + ATP - Streptococcus pneumoniae ? - ? 407591 4.1.1.33 (3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid + ATP - Streptococcus pneumoniae ? - ? 407592 4.1.1.33 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpent-4-enoic acid + ATP - Streptococcus pneumoniae ? - ? 407593 4.1.1.33 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid + ATP - Streptococcus pneumoniae ? - ? 407594 4.1.1.33 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid + ATP - Streptococcus pneumoniae ? - ? 407595 4.1.1.33 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)heptanoic acid + ATP - Streptococcus pneumoniae ? - ? 407596 4.1.1.33 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid + ATP - Streptococcus pneumoniae ? - ? 407597 4.1.1.33 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid + ATP - Streptococcus pneumoniae ? - ? 407598 4.1.1.33 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid + ATP - Streptococcus pneumoniae ? - ? 407599 4.1.1.33 (3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid + ATP - Streptococcus pneumoniae ? - ? 407600 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Cavia porcellus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Sus scrofa ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Haloferax volcanii ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Saccharomyces cerevisiae ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Staphylococcus epidermidis ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Staphylococcus epidermidis ADP + phosphate + isopentenyl diphosphate + CO2 - ir 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Ganoderma lucidum ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Catharanthus roseus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Saccharolobus solfataricus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Bacopa monnieri ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Hevea brasiliensis ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate the enzyme catalyzes a reaction of the classical mevalonate pathway Saccharolobus solfataricus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate the enzyme is implicated in latex metabolism Hevea brasiliensis ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate formation of isopentenyl diphosphate through the ATP-dependent phosphorylation of the 3-hydroxyl group of (R)-5-diphosphomevalonate followed by decarboxylation coupled with the elimination of the 3-phosphate group Saccharolobus solfataricus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Saccharolobus solfataricus P2 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate the enzyme catalyzes a reaction of the classical mevalonate pathway Saccharolobus solfataricus P2 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate formation of isopentenyl diphosphate through the ATP-dependent phosphorylation of the 3-hydroxyl group of (R)-5-diphosphomevalonate followed by decarboxylation coupled with the elimination of the 3-phosphate group Saccharolobus solfataricus P2 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Ganoderma lucidum HG ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Saccharolobus solfataricus JCM 11322 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate formation of isopentenyl diphosphate through the ATP-dependent phosphorylation of the 3-hydroxyl group of (R)-5-diphosphomevalonate followed by decarboxylation coupled with the elimination of the 3-phosphate group Saccharolobus solfataricus JCM 11322 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Saccharolobus solfataricus ATCC 35092 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate formation of isopentenyl diphosphate through the ATP-dependent phosphorylation of the 3-hydroxyl group of (R)-5-diphosphomevalonate followed by decarboxylation coupled with the elimination of the 3-phosphate group Saccharolobus solfataricus ATCC 35092 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate - Saccharolobus solfataricus DSM 1617 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate the enzyme catalyzes a reaction of the classical mevalonate pathway Saccharolobus solfataricus DSM 1617 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R)-5-diphosphomevalonate formation of isopentenyl diphosphate through the ATP-dependent phosphorylation of the 3-hydroxyl group of (R)-5-diphosphomevalonate followed by decarboxylation coupled with the elimination of the 3-phosphate group Saccharolobus solfataricus DSM 1617 ADP + phosphate + isopentenyl diphosphate + CO2 - ? 407111 4.1.1.33 ATP + (R,S)-5-diphosphomevalonate - Staphylococcus epidermidis ADP + phosphate + isopentenyl diphosphate + CO2 - ir 416594 4.1.1.33 ATP + 3-hydroxy-3-methylbutyrate - Saccharomyces cerevisiae ADP + isobutene + CO2 isobutene is identified by gas chromatography with flame ionization detection as well as by GC-mass spectrometry. Isobutene is an important commercial chemical used for the synthesis of butyl rubber, terephthalic acid, specialty chemicals, and a gasoline performance additive known as alkylate ? 411658 4.1.1.33 ATP + 5-diphosphomevalonate - Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Mus musculus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Homo sapiens ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Rattus norvegicus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Sus scrofa ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Saccharomyces cerevisiae ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Pisum sativum ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Arachis hypogaea ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Streptococcus pneumoniae ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Vigna radiata ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Oryza sativa ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Ginkgo biloba ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Trypanosoma brucei ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Staphylococcus aureus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate - Flavobacterium johnsoniae ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate high specificity for ATP Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate high specificity for ATP Cymbopogon citratus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate the enzyme is responsible for regulation of cholesterogenesis. Response to lipoprotein content of culture medium Homo sapiens ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate enzyme activity is increased by 5fold after feeding young rats 2.5% cholestyramine for ten days to four weeks Rattus norvegicus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate the enzyme may play a significant role in the coordinate regulation of the enzymes implied in cholesterol biosynthesis Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate the enzyme may play a significant role in the regulation of cholesterol synthesis in the small intestine Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 ATP + 5-diphosphomevalonate enzyme catalyzes one of the early steps in the biosynthesis of cholesterol from mevalonic acid Saccharomyces cerevisiae ADP + phosphate + isopentenyl diphosphate + CO2 - ? 1408 4.1.1.33 CTP + 5-diphosphomevalonate no activity Sus scrofa CDP + phosphate + isopentenyl diphosphate + CO2 - ? 1410 4.1.1.33 CTP + 5-diphosphomevalonate about 10% of the activity with ATP Cymbopogon citratus CDP + phosphate + isopentenyl diphosphate + CO2 - ? 1410 4.1.1.33 CTP + 5-diphosphomevalonate 12% of the activity with ATP Mus musculus CDP + phosphate + isopentenyl diphosphate + CO2 - ? 1410 4.1.1.33 dATP + 5-diphosphomevalonate about 59% of the activity with ATP Sus scrofa dADP + phosphate + isopentenyl diphosphate + CO2 - ? 1411 4.1.1.33 diphosphomevalonate + ATP - Streptococcus pneumoniae isopentenyl diphosphate + ADP - ? 409324 4.1.1.33 GTP + 5-diphosphomevalonate about 15% of the activity with ATP Cymbopogon citratus GDP + phosphate + isopentenyl diphosphate + CO2 - ? 1409 4.1.1.33 GTP + 5-diphosphomevalonate about 10% of the activity with ATP Sus scrofa GDP + phosphate + isopentenyl diphosphate + CO2 - ? 1409 4.1.1.33 GTP + 5-diphosphomevalonate 25% of the activity with ATP Mus musculus GDP + phosphate + isopentenyl diphosphate + CO2 - ? 1409 4.1.1.33 ITP + 5-diphosphomevalonate about 6% of the activity with ATP Sus scrofa IDP + phosphate + isopentenyl diphosphate + CO2 - ? 1412 4.1.1.33 additional information liver-specific induction of the enzyme by pravastatin Mus musculus ? - ? 89 4.1.1.33 additional information major enzyme involved in cholesterol biosynthesis in rat liver Rattus norvegicus ? - ? 89 4.1.1.33 additional information the enzyme is involved in cholesterol biosynthesis Rattus norvegicus ? - ? 89 4.1.1.33 additional information molecular dynamics simulation to characterize the active site of mevalonate 5-diphosphate decarboxylase to predict a probable mechanism in the transition state Saccharomyces cerevisiae ? - ? 89 4.1.1.33 additional information no substrate: mevalonate 5-phosphate Saccharolobus solfataricus ? - ? 89 4.1.1.33 additional information NMR analysis of the product Saccharolobus solfataricus ? - - 89 4.1.1.33 additional information no substrate: mevalonate 5-phosphate Saccharolobus solfataricus P2 ? - ? 89 4.1.1.33 additional information NMR analysis of the product Saccharolobus solfataricus P2 ? - - 89 4.1.1.33 additional information NMR analysis of the product Saccharolobus solfataricus JCM 11322 ? - - 89 4.1.1.33 additional information NMR analysis of the product Saccharolobus solfataricus ATCC 35092 ? - - 89 4.1.1.33 additional information no substrate: mevalonate 5-phosphate Saccharolobus solfataricus DSM 1617 ? - ? 89 4.1.1.33 additional information NMR analysis of the product Saccharolobus solfataricus DSM 1617 ? - - 89 4.1.1.33 UTP + 5-diphosphomevalonate 13% of the activity with ATP Mus musculus UDP + phosphate + isopentenyl diphosphate + CO2 - ? 367933