3.4.23.20 (4-Nitro)Phe-Nle-Ala-Leu methyl ester + H2O - Penicillium roqueforti Nle-Ala-Leu methyl ester + (4-nitro)Phe - ? 16306 3.4.23.20 Ac-(Ala)m-Lys-(NO2)Phe-(Ala)n amide + H2O - Penicillium janthinellum ? - ? 16300 3.4.23.20 Ac-(Ala)n-Lys-Nph-(Ala)m-amide + H2O - Penicillium janthinellum Ac-(Ala)n-Lys + Nph-(Ala)m-amide - ? 384067 3.4.23.20 Ac-Ala-Ala-Ala-Lys-(NO2)Phe-Ala-Ala-amide + H2O - Penicillium janthinellum ? - ? 366936 3.4.23.20 Ac-Ala-Ala-Lys-(4-nitro)Phe-Ala-Ala amide + H2O - Penicillium janthinellum ? - ? 16303 3.4.23.20 Ac-Ala-Ala-Lys-(4-nitro)Phe-Ala-Ala-Ala amide + H2O - Penicillium janthinellum Ac-Ala-Ala-Lys + (4-nitro)Phe-Ala-Ala-Ala amide - ? 454027 3.4.23.20 Ac-Ala-Ala-Lys-(NO2)Phe-Ala-Ala-amide + H2O - Penicillium janthinellum ? - ? 366935 3.4.23.20 Ac-Ala-Ala-Lys-(NO2)Phe-Ala-amide + H2O - Penicillium janthinellum ? - ? 366932 3.4.23.20 Ac-Ala-Ala-Lys-(NO2)Phe-amide + H2O - Penicillium janthinellum ? - ? 366929 3.4.23.20 Ac-Ala-Ala-Lys-(NO2)Phe-amide + H2O - Penicillium janthinellum NRRL 905 ? - ? 366929 3.4.23.20 Ac-Ala-Ala-Lys-(p-NO2)Phe-Ala-Ala-NH2 + H2O - Penicillium sp. ? - ? 366926 3.4.23.20 Ac-Ala-Lys-(NO2)Phe-Ala-Ala-amide + H2O - Penicillium janthinellum ? - ? 366934 3.4.23.20 Ac-Ala-Lys-(NO2)Phe-Ala-amide + H2O - Penicillium janthinellum ? - ? 366931 3.4.23.20 Ac-Ala-Lys-(NO2)Phe-Ala-amide + H2O - Penicillium janthinellum NRRL 905 ? - ? 366931 3.4.23.20 Ac-Ala-Lys-(NO2)Phe-amide + H2O - Penicillium janthinellum ? - ? 366928 3.4.23.20 Ac-Ala-Lys-(NO2)Phe-amide + H2O - Penicillium janthinellum NRRL 905 ? - ? 366928 3.4.23.20 Ac-Ala-Lys-Ala-(NO2)Phe-amide + H2O - Penicillium janthinellum ? - ? 454028 3.4.23.20 Ac-Gly-Lys-(4-nitro)Phe-Ala-Ala amide + H2O - Penicillium janthinellum Ac-Gly-Lys + (4-nitro)Phe-Ala-Ala amide - ? 453127 3.4.23.20 Ac-Lys 4-nitrophenyl amide + H2O - Penicillium janthinellum ? - ? 16305 3.4.23.20 Ac-Lys-(NO2)Phe- Ala-amide + H2O - Penicillium janthinellum ? - ? 366930 3.4.23.20 Ac-Lys-(NO2)Phe- Ala-amide + H2O - Penicillium janthinellum NRRL 905 ? - ? 366930 3.4.23.20 Ac-Lys-(NO2)Phe-Ala-Ala-amide + H2O - Penicillium janthinellum ? - ? 366933 3.4.23.20 Ac-Lys-(NO2)Phe-amide + H2O - Penicillium janthinellum ? - ? 366927 3.4.23.20 Ac-Lys-(NO2)Phe-amide + H2O - Penicillium janthinellum NRRL 905 ? - ? 366927 3.4.23.20 Ac-Val-Lys-(4-nitro)Phe-Ala amide + H2O - Penicillium janthinellum Ac-Val-Lys + (4-nitro)Phe-Ala amide - ? 453128 3.4.23.20 Ac-Xaa-Lys-(NO2)Phe-Ala-Ala amide + H2O - Penicillium janthinellum ? - ? 16301 3.4.23.20 azocasein + H2O - Penicillium aurantiogriseum ? - ? 15347 3.4.23.20 azocasein + H2O - Penicillium candidum ? - ? 15347 3.4.23.20 azocasein + H2O - Penicillium candidum PCA 1/TT031 ? - ? 15347 3.4.23.20 B-chain of S-sulfo-insulin + H2O - Penicillium janthinellum ? - ? 16296 3.4.23.20 Bovine serum albumin + H2O cleaves 15% of the peptide bonds Penicillium janthinellum ? - ? 16295 3.4.23.20 bovine trypsinogen + H2O - Penicillium janthinellum ? - ? 384364 3.4.23.20 Egg albumin + H2O best substrate, 30% of the peptide bonds are split after 48 h, at 37øC, pH 3.0 Penicillium duponti ? - ? 16299 3.4.23.20 Egg albumin + H2O best substrate, 30% of the peptide bonds are split after 48 h, at 37øC, pH 3.0 Penicillium duponti K 1014 ? - ? 16299 3.4.23.20 FVNQHLCGSHLVEALYLVCGERGFFYTPKA + H2O i.e. insulin B chain, cleavage site specificity Penicillium janthinellum FVNQHLCGSHLVEALYLVCG + ERGFFYTPKA - ? 384741 3.4.23.20 H-Leu-Ser-(4-nitro)Phe-Nle-Ala-Leu methyl ester + H2O - Penicillium roqueforti Nle-Ala-Leu methyl ester + Leu-Ser-(4-nitro)Phe - ? 16307 3.4.23.20 Hemoglobin + H2O - Penicillium canescens ? - ? 15450 3.4.23.20 Hemoglobin + H2O best substrate, 30% of the peptide bonds are split after 48 h, at 37øC, pH 3.0 Penicillium duponti ? - ? 15450 3.4.23.20 Hemoglobin + H2O best substrate, 30% of the peptide bonds are split after 48 h, at 37øC, pH 3.0 Penicillium duponti K 1014 ? - ? 15450 3.4.23.20 Hemoglobin + H2O - Penicillium canescens RN3-11-7 niaD(-) ? - ? 15450 3.4.23.20 Leu-Ser-(4-nitro)Phe-Nle-Ala-Leu methyl ester + H2O - Penicillium janthinellum ? - ? 16304 3.4.23.20 Milk casein + H2O - Penicillium duponti ? - ? 16297 3.4.23.20 Milk casein + H2O - Penicillium duponti K 1014 ? - ? 16297 3.4.23.20 additional information acts on some small substrates with two hydrophobic amino acids at the N-terminus and a free amino group, in addition to removing the N-terminal amino acid hydrolytically a trans-peptidation reaction occurs: Leu-Leu is formed from Leu-Tyr-Leu, Phe-Phe from Phe-Tyr-Thr-Pro-Lys-Ala and Met-Met from Met-Leu-Gly Penicillium janthinellum ? - ? 89 3.4.23.20 additional information transpeptidation reaction of both the amino acid and the acyl transfer type Penicillium janthinellum ? - ? 89 3.4.23.20 additional information milk clotting activity Penicillium expansum ? - ? 89 3.4.23.20 additional information broad protein substrate specificity Penicillium duponti ? - ? 89 3.4.23.20 additional information broad protein substrate specificity Penicillium roqueforti ? - ? 89 3.4.23.20 additional information broad protein substrate specificity Penicillium camemberti ? - ? 89 3.4.23.20 additional information broad protein substrate specificity with preference for hydrophobic residues at positions P1 and P1', especially for Lys in P1 because the epsilon-amino group forms an ionic bond with the side-chain carboxylate of Asp77, substrate specificity involves the side chain of the P3 residue, mechanism, detailed overview Penicillium janthinellum ? - ? 89 3.4.23.20 additional information substrate binding specificity, cleavage site specificity, overview Penicillium janthinellum ? - ? 89 3.4.23.20 additional information broad protein substrate specificity Penicillium duponti K1014 ? - ? 89 3.4.23.20 Pro-Thr-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O - Penicillium janthinellum Pro-Thr-Glu-Phe + (4-nitro)Phe-Arg-Leu - ? 16302 3.4.23.20 trypsin inhibitor + H2O substrate from Cucurbita maxima, specific cleavage of Leu7-Met8 bond at pH 3.3 Penicillium camemberti trypsin inhibitor fragments - ? 385854 3.4.23.20 Trypsinogen + H2O - Penicillium duponti ? - ? 16266 3.4.23.20 Trypsinogen + H2O - Penicillium janthinellum ? - ? 16266 3.4.23.20 Trypsinogen + H2O bovine, activation by cleavage of Lys6-Ile7 Penicillium janthinellum ? - ? 16266 3.4.23.20 Trypsinogen + H2O - Penicillium duponti K 1014 ? - ? 16266 3.4.23.20 trypsinogen + H2O substrate from Bos taurus, rapid activation Penicillium janthinellum trypsin + propeptide Val(Asn)4-Lys-OH - ? 385855 3.4.23.20 trypsinogen + H2O rapid activation Penicillium duponti trypsin + Val(Asn)4-Lys - ? 385856 3.4.23.20 trypsinogen + H2O rapid activation Penicillium roqueforti trypsin + Val(Asn)4-Lys - ? 385856 3.4.23.20 trypsinogen + H2O rapid activation Penicillium camemberti trypsin + Val(Asn)4-Lys - ? 385856 3.4.23.20 trypsinogen + H2O rapid activation Penicillium duponti K1014 trypsin + Val(Asn)4-Lys - ? 385856 3.4.23.20 wheat flour + H2O - Penicillium canescens ? - ? 448256 3.4.23.20 wheat flour + H2O - Penicillium canescens RN3-11-7 niaD(-) ? - ? 448256