3.4.22.44 acetyl-Arg-Glu-Thr-Val-Arg-Phe-Gln-Ser-Asp-amide + H2O - tobacco vein mottling virus ? - ? 95024 3.4.22.44 acetyl-Arg-Glu-Thr-Val-Arg-Phe-Gln-Ser-Asp-amide + H2O - tobacco vein mottling virus TVMV ? - ? 95024 3.4.22.44 acetyl-Asn-Asn-Val-Arg-Phe-Gln-Ser-Leu-amide + H2O - tobacco vein mottling virus acetyl-Asn-Asn-Val-Arg-Phe-Gln + Ser-Leu-amide - ? 95023 3.4.22.44 acetyl-Asn-Asn-Val-Arg-Phe-Gln-Ser-Leu-amide + H2O - tobacco vein mottling virus TVMV acetyl-Asn-Asn-Val-Arg-Phe-Gln + Ser-Leu-amide - ? 95023 3.4.22.44 acetyl-Glu-Pro-Thr-Val-Tyr-His-Gln-Thr-Leu-amide + H2O - turnip mosaic potyvirus ? - ? 95022 3.4.22.44 acetyl-Glu-Pro-Thr-Val-Tyr-His-Gln-Thr-Leu-amide + H2O - turnip mosaic potyvirus TuMV ? - ? 95022 3.4.22.44 amyloid beta + H2O the enzyme cleaves monomeric and oligomeric amyloid beta at a similar rate in vitro turnip mosaic virus ? - ? 431588 3.4.22.44 amyloid-beta + H2O - turnip mosaic virus ? - ? 365809 3.4.22.44 amyloid-beta peptide + H2O degradation of oligomeric as well as monomeric forms of Amyloid-beta, presence of the consensus sequence, Val12-His-His-Gln15, near the presumptive alpha-secretase cleavage site of the amyloid-beta peptide turnip mosaic virus ? - ? 367380 3.4.22.44 additional information consensus substrate sequence: Yaa-Val-Arg-His-Gln-/-Ser, with Yaa being a aliphatic amino acid and the scissile bond being located between Gln and Ser turnip mosaic potyvirus ? - ? 89 3.4.22.44 additional information interaction between purified recombinant NIa-Pro and VPg domains, overview Chilli veinal mottle virus ? - ? 89 3.4.22.44 additional information NIa possesses a relatively strict substrate specificity with a preference for Val-Xaa-His-GlnQ, with the scissile bond located after Gln turnip mosaic virus ? - ? 89 3.4.22.44 additional information the S3 and S4 pockets are mainly responsible for the substrate specificity, comparison to the specificity of the tobacco etch virus, TEV, protease, structural determinants of substrate specificity, overview. The TVMV protease is less tolerant of variation at the P1' position than TEV protease, and substitutions in the P6 position are more readily tolerated by TVMV than TEV protease tobacco vein mottling virus ? - ? 89 3.4.22.44 additional information the enzyme interacts with proteins EIF3G, FBPA1, FK506BP, GTPBP, MSRB1, and MTL papaya ringspot virus ? - ? 89 3.4.22.44 additional information consensus substrate sequence: Yaa-Val-Arg-His-Gln-/-Ser, with Yaa being a aliphatic amino acid and the scissile bond being located between Gln and Ser turnip mosaic potyvirus TuMV ? - ? 89 3.4.22.44 nuclear inclusion protein a + H2O - tobacco vein mottling virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - tobacco etch virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - turnip mosaic potyvirus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - Plum pox virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - papaya ringspot virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - turnip mosaic virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - Chilli veinal mottle virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O identification of cleavage site Plum pox virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O analysis of cleavage sites, specific for its own polypeptide chain, no cleavage of other potyvirus NIa proteins tobacco vein mottling virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O analysis of cleavage sites, specific for its own polypeptide chain, no cleavage of other potyvirus NIa proteins tobacco etch virus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O the nuclear inclusion protein of potyviruses has two domains, the Vpg domain of 22 kDa and the C-terminal domain of 27 kDa which has proteolytic activity. The first cleavage at Ser223-Gly224 produces a 25 kDa protein. TuMV cleaves itself in cis, removing a 20 amino aicd peptide from the C-terminus. A second cleavage is very slow and occurs between Thr207-Ser208, resulting in a 24 kDa protein turnip mosaic potyvirus ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - Plum pox virus PPV ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - tobacco vein mottling virus TVMV ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O the nuclear inclusion protein of potyviruses has two domains, the Vpg domain of 22 kDa and the C-terminal domain of 27 kDa which has proteolytic activity. The first cleavage at Ser223-Gly224 produces a 25 kDa protein. TuMV cleaves itself in cis, removing a 20 amino aicd peptide from the C-terminus. A second cleavage is very slow and occurs between Thr207-Ser208, resulting in a 24 kDa protein turnip mosaic potyvirus TuMV ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - turnip mosaic potyvirus TuMV ? - ? 95021 3.4.22.44 nuclear inclusion protein a + H2O - tobacco etch virus TEV ? - ? 95021 3.4.22.44 P-sG polyprotein + H2O - Plum pox virus ? - ? 431093 3.4.22.44 Pro-Thr-Thr-Glu-Leu-Tyr-Phe-Gln-Ser-Gly-Thr-Val-Asp-Arg-Arg + H2O - tobacco etch virus Pro-Thr-Thr-Glu-Leu-Tyr-Phe-Gln + Ser-Gly-Thr-Val-Asp-Arg-Arg - ? 95025 3.4.22.44 Pro-Thr-Thr-Glu-Leu-Tyr-Phe-Gln-Ser-Gly-Thr-Val-Asp-Arg-Arg + H2O - tobacco etch virus TEV Pro-Thr-Thr-Glu-Leu-Tyr-Phe-Gln + Ser-Gly-Thr-Val-Asp-Arg-Arg - ? 95025 3.4.22.44 RETVRFQSD + H2O - tobacco vein mottling virus ? - ? 419034 3.4.22.44 TETVRFQSGTRR + H2O - tobacco vein mottling virus ? - ? 419141 3.4.22.44 turnip mosaic virus polyprotein + H2O cleaved at seven differnt locations turnip mosaic potyvirus ? - ? 366886 3.4.22.44 turnip mosaic virus polyprotein + H2O cleaved at seven differnt locations turnip mosaic potyvirus TuMV ? - ? 366886 3.4.22.44 WDGGEVAHQAGESV + H2O - Chilli veinal mottle virus WDGGEVAHQ + AGESV - ? 419197