3.4.22.43 2-aminobenzoyl-ALRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O best substrate Homo sapiens ? - ? 383648 3.4.22.43 2-aminobenzoyl-EE-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O - Homo sapiens ? - ? 383654 3.4.22.43 2-aminobenzoyl-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O - Homo sapiens ? - ? 383655 3.4.22.43 2-aminobenzoyl-KK-epsilon-amino-caproic acid-ELKLQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O - Homo sapiens ? - ? 383671 3.4.22.43 2-aminobenzoyl-KLRSIKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O best substrate Homo sapiens 2-aminobenzoyl-KLR + SIKQ-N-(2,4-dinitrophenyl)ethylenediamine - ? 383672 3.4.22.43 2-aminobenzoyl-KLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O - Homo sapiens ? - ? 453098 3.4.22.43 2-aminobenzoyl-KLRSXKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O X is varied with diverse amino acids, highest activity with Ile, kinetics, detailed overview Homo sapiens 2-aminobenzoyl-KLR + SXKQ-N-(2,4-dinitrophenyl)ethylenediamine - ? 383673 3.4.22.43 2-aminobenzoyl-KLRVSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O - Homo sapiens ? - ? 453099 3.4.22.43 2-aminobenzoyl-KLRXSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O X is varied with diverse amino acids, highest activity with Val, kinetics, detailed overview Homo sapiens 2-aminobenzoyl-KLR + XSKQ-N-(2,4-dinitrophenyl)ethylenediamine - ? 383674 3.4.22.43 2-aminobenzoyl-KLXSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O X is varied with diverse amino acids, highest activity with Arg, kinetics, detailed overview Homo sapiens 2-aminobenzoyl-KLX + SSKQ-N-(2,4-dinitrophenyl)ethylenediamine - ? 383675 3.4.22.43 2-aminobenzoyl-KPPVVLLPDQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O - Homo sapiens 2-aminobenzoyl-KPPVV + LLPDQ-N-[2,4-dinitrophenyl]ethylenediamine - ? 411239 3.4.22.43 2-aminobenzoyl-KPVSTEQLAQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O - Homo sapiens 2-aminobenzoyl-KPVS + TEQLAQ-N-[2,4-dinitrophenyl]ethylenediamine - ? 411240 3.4.22.43 2-aminobenzoyl-KXRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O X is varied with diverse amino acids, highest activity with Leu, kinetics, detailed overview Homo sapiens ? - ? 383676 3.4.22.43 2-aminobenzoyl-LFEKQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O - Homo sapiens 2-aminobenzoyl-LF + EKQ-N-[2,4-dinitrophenyl]ethylenediamine - ? 411241 3.4.22.43 2-aminobenzoyl-VLFEKKQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O selective substrate for cathepsin V when compared with cathepsins B, L, and S Homo sapiens 2-aminobenzoyl-VLF + EKKQ-N-[2,4-dinitrophenyl]ethylenediamine - ? 411243 3.4.22.43 2-aminobenzoyl-VLFEKKVYLQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O - Homo sapiens 2-aminobenzoyl-VLF + EKKVY + LQ-N-[2,4-dinitrophenyl]ethylenediamine - ? 411244 3.4.22.43 2-aminobenzoyl-VLFEKQ-N-[2,4-dinitrophenyl]ethylenediamine + H2O - Homo sapiens 2-aminobenzoyl-VLF + EKQ-N-[2,4-dinitrophenyl]ethylenediamine - ? 411245 3.4.22.43 2-aminobenzoyl-XLRSSKQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O X is varied with diverse amino acids, highest activity with Ala, kinetics, detailed overview Homo sapiens ? - ? 383744 3.4.22.43 Albumin + H2O - Homo sapiens ? - ? 16041 3.4.22.43 benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin - ? 362766 3.4.22.43 benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin - ? 361886 3.4.22.43 benzyloxycarbonyl-Val-Val-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens benzyloxycarbonyl-Val-Val-Arg + 7-amino-4-methylcoumarin - ? 362763 3.4.22.43 Boc-Gly-Lys-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens Boc-Gly-Lys-Arg + 7-amino-4-methylcoumarin - ? 428449 3.4.22.43 Bovine serum albumin + H2O - Homo sapiens ? - ? 16295 3.4.22.43 Cbz-Phe-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens Cbz-Phe-Arg + 7-amino-4-methylcoumarin - ? 15912 3.4.22.43 Elastin + H2O - Homo sapiens ? - ? 16576 3.4.22.43 Elastin + H2O elastin degradation activity leading to loss of elasticity in atherosclerosis Homo sapiens ? - ? 16576 3.4.22.43 Elastin + H2O the enzyme exhibits high elastolytic cysteine protease activity Homo sapiens ? - ? 16576 3.4.22.43 Gelatin + H2O - Homo sapiens ? - ? 16570 3.4.22.43 kininogen fragments + H2O kininogenase activity with high and low molecular weight kininogens Homo sapiens ? Lys-bradykinin is the major product ? 384954 3.4.22.43 MHC class II-associated invariant chain + H2O - Homo sapiens ? - ? 385187 3.4.22.43 additional information the corneal enzyme stays within cells and is not secreted, suggesting that components of the corneal epithelium are likely substrates Homo sapiens ? - ? 89 3.4.22.43 additional information the predominant expression in thymus suggests a role in the immune system, the expression in testes suggests a role in fertilization processes, the expression in cancer cells together with its absence in normal cells suggests a role in tumor processes Homo sapiens ? - ? 89 3.4.22.43 additional information the enzyme and inhibitor cystatin M/E are involved in regulation of epidermal differentiation Homo sapiens ? - ? 89 3.4.22.43 additional information the enzyme can stimulate H2O2 production, enzyme expression is increased in keratoconus corneas compared to healthy ones, oxidative stress might be involved in the disorder Homo sapiens ? - ? 89 3.4.22.43 additional information substrate and cleavage site specificity of activated recombinant enzyme, comparison to cathepsin L, overview Homo sapiens ? - ? 89 3.4.22.43 additional information the enzyme prefers hydrophobic residues in its S2-binding pocket, the substrate specificity is similar to cathepsin L, no cleavage of the triple-helical region of native collagen Homo sapiens ? - ? 89 3.4.22.43 additional information the human transglutaminase zymogen is no substrate for the enzyme Homo sapiens ? - ? 89 3.4.22.43 additional information direct interaction of cathepsin V with TLR4 and its adaptor protein MyD88 Homo sapiens ? - ? 89 3.4.22.43 N-benzyloxycarbonyl-L-Arg-4-methylcoumarin 7-amide + H2O very low activity Homo sapiens N-benzyloxycarbonyl-L-Arg + 7-amino-4-methylcoumarin - ? 95019 3.4.22.43 N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide + H2O very low activity Homo sapiens N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin - ? 95012 3.4.22.43 N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O - Homo sapiens N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin - ? 95009 3.4.22.43 N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O Cbz-Phe-Arg-AMC, 25 microM used for protease inhibition assay, inhibitory conditions of cathepsin V propeptide analyzed Homo sapiens N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin - ? 95009 3.4.22.43 N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O mechanisms of interaction between serpins, human cathepsin V and DNA analyzed, kinetic constants for substrate cleavage in the presence and absence of cofactors determined, final concentrations of cathepsin V and ds65mer DNA at 0.1 and 10 nM, final substrate concentrations ranging from 5 to 200 microM in cathepsin V buffer Homo sapiens N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin - ? 95009 3.4.22.43 neuropeptide Y + H2O - Homo sapiens ? - ? 367217 3.4.22.43 plasminogen + H2O - Homo sapiens ? - ? 74447 3.4.22.43 plasminogen + H2O capability of recombinant human cathepsin V to hydrolyze plasminogen analyzed, physiological role for cathepsin V related to the control of neovascularization in cornea suggested Homo sapiens ? - ? 74447 3.4.22.43 plasminogen + H2O 4.5 microM human plasminogen and 30 nM of recombinant human cathepsins V used for plasminogen digestion assay, three major products of 60, 50 and 40 kDa obtained, SDS-PAGE Homo sapiens ? - ? 74447 3.4.22.43 plasminogen + H2O cathepsin V hydrolyzes plasminogen at Phe94-Glu95, Ser358-Thr359, and Val468-Leu469 generating angiostatin-related fragments Homo sapiens ? - ? 74447 3.4.22.43 proenkephalin + H2O - Homo sapiens (Met)enkephalin + ? - ? 431146 3.4.22.43 Type I collagen + H2O cleavage of telopeptide region Homo sapiens ? - ? 16730 3.4.22.43 Z-Arg-Arg-4-methoxy-2-nitroanilide + H2O - Homo sapiens Z-Arg-Arg + 4-methoxy-2-nitroaniline - ? 385949 3.4.22.43 Z-Arg-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens Z-Arg-Arg + 7-amino-4-methylcoumarin - ? 385950 3.4.22.43 Z-Leu-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens Z-Leu-Arg + 7-amino-4-methylcoumarin - ? 385963 3.4.22.43 Z-Phe-Arg-4-methylcoumarin-7-amide + H2O - Homo sapiens Z-Phe-Arg + 7-amino-4-methylcoumarin - ? 385968 3.4.22.43 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O - Homo sapiens Z-Phe-Arg + 7-amino-4-methylcoumarin - ? 385972 3.4.22.43 Z-Phe-Arg-7-amido-4-methylcoumarin + H2O role of cathepsis V and the endogenous inhibitor cystatin C in adverse extracellular matrix remodeling of stenotic aortic valves analyzed Homo sapiens Z-Phe-Arg + 7-amino-4-methylcoumarin - ? 385972