3.4.19.3 2-oxoimidazolidinyl-4-carbonyl-Gly-Ile + H2O - Bos taurus ? - ? 74094 3.4.19.3 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O - Mus musculus L-2-oxothiazolidine-4-carboxylic acid + ? - ? 383872 3.4.19.3 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O - Homo sapiens L-2-oxothiazolidine-4-carboxylic acid + ? - ? 383872 3.4.19.3 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O - Rattus norvegicus L-2-oxothiazolidine-4-carboxylic acid + ? - ? 383872 3.4.19.3 5-pyrrolidone-2-carboxyl-His-Gly + H2O slight activity Cavia porcellus ? - ? 74096 3.4.19.3 5-pyrrolidone-2-carboxyl-His-Trp + H2O - Cavia porcellus ? - ? 74095 3.4.19.3 ACE inhibitor + H2O contains the N-terminal dipeptide pyroglutamyl-Trp- Homo sapiens pyroglutamate + ? - ? 365093 3.4.19.3 acid-thyroliberin + H2O - Cavia porcellus pyroglutamate + His-Pro - ? 74088 3.4.19.3 acid-thyroliberin + H2O i.e. pyroglutamyl-His-Pro Cavia porcellus pyroglutamate + His-Pro - ? 74088 3.4.19.3 bombesin + H2O - Bos taurus pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 - ? 74099 3.4.19.3 bombesin + H2O i.e. pyroglutamyl-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 Cavia porcellus pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 - ? 74099 3.4.19.3 bombesin + H2O contains the N-terminal dipeptide pyroglutamyl-Arg- Homo sapiens pyroglutamate + ? - ? 365089 3.4.19.3 bradykinin potentiator + H2O - Gallus gallus pyroglutamate + ? - ? 74101 3.4.19.3 bradykinin potentiator + H2O - Bacillus amyloliquefaciens pyroglutamate + ? - ? 74101 3.4.19.3 bradykinin potentiator B + H2O contains the N-terminal dipeptide pyroglutamyl-Gly- Homo sapiens pyroglutamate + ? - ? 365091 3.4.19.3 bradykinin-potentiating peptide B + H2O cleavage of the peptide bond adjacent to the pyroglutamic residue Cavia porcellus ? - ? 74100 3.4.19.3 ethyl L-pyroglutamate + H2O - Thermococcus litoralis L-pyroglutamate + ethanol - ? 428610 3.4.19.3 ethyl L-pyroglutamate + H2O - Thermococcus litoralis DSM 5473 L-pyroglutamate + ethanol - ? 428610 3.4.19.3 Fibrinogen + H2O bovine fribrinogen Pseudomonas fluorescens ? - ? 15619 3.4.19.3 Glu(OMe)2-litorin + H2O - Bacillus amyloliquefaciens pyroglutamate + ? - ? 74104 3.4.19.3 gonadotropin-releasing hormone + H2O hydrolyzed exclusively at the pyroglutamyl-/-Xaa bond Trypanosoma brucei brucei ? - ? 384835 3.4.19.3 L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O - Mus musculus ? - ? 384959 3.4.19.3 L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O - Homo sapiens ? - ? 384959 3.4.19.3 L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O - Rattus norvegicus ? - ? 384959 3.4.19.3 L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate + H2O - Rattus norvegicus ? - ? 384960 3.4.19.3 L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O - Mus musculus ? - ? 384961 3.4.19.3 L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O - Homo sapiens ? - ? 384961 3.4.19.3 L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O - Rattus norvegicus ? - ? 384961 3.4.19.3 L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate + H2O - Rattus norvegicus ? - ? 384962 3.4.19.3 L-2-oxothiazolidine-4-carboxyl-ethanolamine + H2O - Rattus norvegicus ? - ? 384963 3.4.19.3 L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate + H2O - Rattus norvegicus ? - ? 384964 3.4.19.3 L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O - Mus musculus ? - ? 384965 3.4.19.3 L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O - Homo sapiens ? - ? 384965 3.4.19.3 L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O - Rattus norvegicus ? - ? 384965 3.4.19.3 L-pyroglutamic acid 2-naphthylamide + H2O - Crotalus durissus terrificus L-pyroglutamate + 2-naphthylamine - ? 412330 3.4.19.3 L-pyroglutamyl p-nitroanilide + H2O - Pyrococcus furiosus L-pyroglutamate + p-nitroaniline - ? 392410 3.4.19.3 L-pyroglutamyl-7-amido-4-methylcoumarin + H2O - Trypanosoma brucei brucei L-pyroglutamate + 7-amino-4-methylcoumarin - ? 385054 3.4.19.3 L-pyroglutamyl-aminoethylnitrate + H2O - Rattus norvegicus ? - ? 385055 3.4.19.3 L-pyroglutamyl-beta-naphthylamide + H2O - Rattus norvegicus L-pyroglutamate + beta-naphthylamine - ? 365086 3.4.19.3 L-pyroglutamyl-beta-naphthylamide + H2O - Bos taurus L-pyroglutamate + beta-naphthylamine - ? 365086 3.4.19.3 L-pyroglutamyl-beta-naphthylamide + H2O - Bacillus amyloliquefaciens L-pyroglutamate + beta-naphthylamine - ? 365086 3.4.19.3 L-pyroglutamyl-beta-naphthylamide + H2O - Thermococcus litoralis L-pyroglutamate + beta-naphthylamine - ? 365086 3.4.19.3 L-pyroglutamyl-beta-naphthylamide + H2O - Leishmania major L-pyroglutamate + 2-naphtylamine - ? 392411 3.4.19.3 L-pyroglutamyl-beta-naphthylamide + H2O - Rattus norvegicus L-pyroglutamate + beta-naphtylamine - ? 392412 3.4.19.3 L-pyroglutamyl-beta-naphthylamide + H2O - Thermococcus litoralis L-pyroglutamate + 2-naphthylamine - ? 428749 3.4.19.3 L-pyroglutamyl-beta-naphthylamide + H2O - Thermococcus litoralis DSM 5473 L-pyroglutamate + 2-naphthylamine - ? 428749 3.4.19.3 L-pyroglutamyl-His-Pro-4-methylcoumarin 7-amide + H2O - Bos taurus L-pyroglutamate + His-Pro-4-methylcoumarin 7-amide - ? 74132 3.4.19.3 L-pyroglutamyl-L-Ala + H2O - Gallus gallus L-pyroglutamate + L-Ala - ? 385056 3.4.19.3 L-pyroglutamyl-L-Ala + H2O - Mus musculus L-pyroglutamate + L-Ala - ? 385056 3.4.19.3 L-pyroglutamyl-L-Ala + H2O - Homo sapiens L-pyroglutamate + L-Ala - ? 385056 3.4.19.3 L-pyroglutamyl-L-Ala + H2O - Rattus norvegicus L-pyroglutamate + L-Ala - ? 385056 3.4.19.3 L-pyroglutamyl-L-Ile + H2O - Bacillus amyloliquefaciens L-pyroglutamate + L-Ile - ? 452949 3.4.19.3 L-pyroglutamyl-L-Thr + H2O - Bacillus amyloliquefaciens L-pyroglutamate + L-Thr - ? 452950 3.4.19.3 L-pyroglutamyl-p-nitroanilide + H2O - Pyrococcus furiosus L-pyroglutaminic acid + p-nitroaniline - ? 365087 3.4.19.3 L-pyroglutamyl-p-nitroanilide + H2O - Leishmania major L-pyroglutamate + p-nitroaniline - ? 385060 3.4.19.3 L-pyroglutamyl-p-nitroanilide + H2O - Homo sapiens L-pyroglutamate + p-nitroaniline - ? 385060 3.4.19.3 L-pyroglutamyl-p-nitroanilide + H2O - Mus musculus L-pyroglutamate + p-nitroaniline - ? 385060 3.4.19.3 L-pyroglutamyl-p-nitroanilide + H2O - Trypanosoma brucei brucei L-pyroglutamate + p-nitroaniline - ? 385060 3.4.19.3 L-pyroglutamyl-p-nitroanilide + H2O - Rattus norvegicus L-pyroglutamate + p-nitroaniline - ? 385060 3.4.19.3 L-pyrrolidonyl 2-naphthylamide + H2O - Clostridioides difficile 5-oxo-L-proline + 2-naphthylamine - ? 428750 3.4.19.3 leukopyrokinin + H2O contains the N-terminal dipeptide pyroglutamyl-Thr- Homo sapiens pyroglutamate + ? - ? 365094 3.4.19.3 litorin + H2O frog litorin Gallus gallus pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 - ? 74102 3.4.19.3 litorin + H2O frog litorin Bacillus amyloliquefaciens pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2 - ? 74102 3.4.19.3 luliberin + H2O - Homo sapiens pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 - ? 74109 3.4.19.3 luliberin + H2O i.e. pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 Cavia porcellus pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 - ? 74109 3.4.19.3 luteinizing hormone releasing hormone + H2O contains the N-terminal dipeptide pyroglutamyl-His- Homo sapiens pyroglutamate + ? - ? 365092 3.4.19.3 luteinizing-hormone-releasing hormone + H2O - Gallus gallus ? - ? 74107 3.4.19.3 luteinizing-hormone-releasing hormone + H2O - Bos taurus ? - ? 74107 3.4.19.3 luteinizing-hormone-releasing hormone + H2O - Bacillus amyloliquefaciens ? - ? 74107 3.4.19.3 additional information - Pseudomonas fluorescens ? - ? 89 3.4.19.3 additional information no hydrolysis of dipeptides containing N-terminal pyroglutamic acid or with pyroglutamyl peptides containing more than three amino acids Cavia porcellus ? - ? 89 3.4.19.3 additional information the enzyme is inactive towards uperolein and piperidone carbonyl His-Pro-NH2 Gallus gallus ? - ? 89 3.4.19.3 additional information slight activity toward L-pyroglutamyl-D-amino acids, inert toward L-pyroglutamyl-L-Pro Bacillus amyloliquefaciens ? - ? 89 3.4.19.3 additional information the enzyme does not catalyze the hydrolysis of peptides with six-membered ureido rings at the amino terminus, but it tolerates well a five-membered ureido ring at this position Bos taurus ? - ? 89 3.4.19.3 additional information the molecular recognition of pyroglutamic acid is achieved through two hydrogen bonds and an insertion in the hydrophobic pocket. In the pocket Phe10 is more important to the hydrophobic interaction than is Phe142 and furthermore Phe13 serves as an induced fit mechanism Bacillus amyloliquefaciens ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Cavia porcellus ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Homo sapiens ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Rattus norvegicus ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Sus scrofa ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Bos taurus ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Oryctolagus cuniculus ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Enterobacter cloacae ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Streptococcus pyogenes ? - ? 89 3.4.19.3 additional information the enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides Enterococcus faecium ? - ? 89 3.4.19.3 additional information diurnal variation and left-right distribution of pyroglutamyl peptidase I activity in the rat brain and retina Rattus norvegicus ? - ? 89 3.4.19.3 additional information pyroglutamyl peptidase I levels and their left-right distribution in the rat retina and hypothalamus are influenced by light-dark conditions Rattus norvegicus ? - ? 89 3.4.19.3 additional information pyroglutamate and iron regulate the expression of the enzyme Pseudomonas fluorescens ? - ? 89 3.4.19.3 additional information enzyme may participate in regulating the levels of seminal thyrotropin-relasing hormone analogues and in mediating sperm death associated with necrozoospermia Homo sapiens ? - ? 89 3.4.19.3 additional information the enzyme might not be dominantly involved in the degradation of thyrotropin-releasing hormone in rats Rattus norvegicus ? - ? 89 3.4.19.3 additional information PGAP performs enzymatic deblocking of pyroglutamylated immunoglobulins. Unfolding of immunoglobulins is required for excision of the pyroglutamate. The enzyme requires the substrate in an extended conformation, which is not fullfiled in the native form of immunoglobulins Pyrococcus furiosus ? - ? 89 3.4.19.3 additional information pyroglutamate and iron regulate the expression of the enzyme Pseudomonas fluorescens MFO ? - ? 89 3.4.19.3 N-(4-methyl-2-oxo-2H-chromen-7-yl)-5-oxo-L-prolinamide + H2O - Gallus gallus 5-oxo-L-proline + 7-amino-4-methylcoumarin - ? 74112 3.4.19.3 neurotensin + H2O - Gallus gallus pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu - ? 74098 3.4.19.3 neurotensin + H2O - Homo sapiens pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu - ? 74098 3.4.19.3 neurotensin + H2O - Bos taurus pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu - ? 74098 3.4.19.3 neurotensin + H2O - Bacillus amyloliquefaciens pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu - ? 74098 3.4.19.3 neurotensin + H2O i.e. pyroglutamyl-Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu Cavia porcellus pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu - ? 74098 3.4.19.3 neurotensin + H2O contains the N-terminal dipeptide pyroglutamyl-Leu- Homo sapiens pyroglutamate + ? - ? 365090 3.4.19.3 physalaemin + H2O - Gallus gallus pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2 - ? 74105 3.4.19.3 physalaemin + H2O - Bacillus amyloliquefaciens pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2 - ? 74105 3.4.19.3 pyroglutamic acid-7-amido-4-methylcoumarin + H2O - Bos taurus L-pyroglutamate + 7-amino-4-methylcoumarin - ? 393391 3.4.19.3 pyroglutamyl-2-naphthylamide + H2O - Rattus norvegicus pyroglutamate + 2-naphthylamine - ? 385647 3.4.19.3 pyroglutamyl-4-methylcoumarin 7-amide + H2O - Cavia porcellus pyroglutamate + 7-amino-4-methylcoumarin - ? 74108 3.4.19.3 pyroglutamyl-4-methylcoumarin 7-amide + H2O - Homo sapiens pyroglutamate + 7-amino-4-methylcoumarin - ? 74108 3.4.19.3 pyroglutamyl-4-methylcoumarin 7-amide + H2O - Bos taurus pyroglutamate + 7-amino-4-methylcoumarin - ? 74108 3.4.19.3 pyroglutamyl-4-methylcoumaryl-7-amide + H2O - Homo sapiens pyroglutamate + 7-amino-4-methylcoumarin - ? 365088 3.4.19.3 pyroglutamyl-4-methylumbelliferyl ester + H2O - Bacillus amyloliquefaciens ? - ? 74113 3.4.19.3 pyroglutamyl-Ala + H2O - Cavia porcellus pyroglutamate + Ala - ? 74114 3.4.19.3 pyroglutamyl-Ala + H2O - Pseudomonas fluorescens pyroglutamate + Ala - ? 74114 3.4.19.3 pyroglutamyl-Ala + H2O - Bacillus amyloliquefaciens pyroglutamate + Ala - ? 74114 3.4.19.3 pyroglutamyl-Arg + H2O - Bacillus amyloliquefaciens pyroglutamate + Arg - ? 74130 3.4.19.3 pyroglutamyl-Asp + H2O - Bacillus amyloliquefaciens pyroglutamate + Asp - ? 74127 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Gallus gallus pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Bacillus subtilis pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Rattus norvegicus pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Bos taurus pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Pseudomonas fluorescens pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Enterococcus faecalis pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Streptococcus pyogenes pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - no activity in Staphylococcus aureus pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus pseudintermedius pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - no activity in Staphylococcus pseudintermedius pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini MI 09-8445 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - no activity in Staphylococcus aureus ATCC 25923 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus pseudintermedius LMG 22219T pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini 56-039 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini 53-033 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini VPP 12 D pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Enterococcus faecalis ATCC 29212 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini 52-006 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini 56-021 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini 62-031 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini MI 16-1129 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - no activity in Staphylococcus pseudintermedius LMG 22219T pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini MI 09-2894 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-beta-naphthylamide + H2O - Staphylococcus delphini 49-046 pyroglutamate + beta-naphthylamine - ? 74110 3.4.19.3 pyroglutamyl-D-Ala + H2O - Bacillus amyloliquefaciens pyroglutamate + D-Ala - ? 74115 3.4.19.3 pyroglutamyl-D-Ala + H2O slight activity Gallus gallus pyroglutamate + D-Ala - ? 74115 3.4.19.3 pyroglutamyl-D-Leu + H2O - Bacillus amyloliquefaciens pyroglutamate + D-Leu - ? 74119 3.4.19.3 pyroglutamyl-Glu + H2O - Bacillus amyloliquefaciens pyroglutamate + Glu - ? 74128 3.4.19.3 pyroglutamyl-Gly + H2O - Bacillus amyloliquefaciens pyroglutamate + Gly - ? 74117 3.4.19.3 pyroglutamyl-Gly-Ile + H2O - Bos taurus pyroglutamate + Gly-Ile - ? 74089 3.4.19.3 pyroglutamyl-His + H2O - Bacillus amyloliquefaciens pyroglutamate + His - ? 74129 3.4.19.3 pyroglutamyl-His-Gly + H2O - Cavia porcellus pyroglutamate + His-Gly - ? 74106 3.4.19.3 pyroglutamyl-His-Gly + H2O - Bos taurus pyroglutamate + His-Gly - ? 74106 3.4.19.3 pyroglutamyl-His-Gly + H2O i.e. anorexogenic peptide Cavia porcellus pyroglutamate + His-Gly - ? 74106 3.4.19.3 pyroglutamyl-His-Gly-NH2 + H2O - Cavia porcellus pyroglutamate + His-Gly-NH2 - ? 74091 3.4.19.3 pyroglutamyl-His-Gly-NH2 + H2O - Bos taurus pyroglutamate + His-Gly-NH2 - ? 74091 3.4.19.3 pyroglutamyl-His-Pro-Gly + H2O - Bos taurus pyroglutamate + His-Pro-Gly - ? 74092 3.4.19.3 pyroglutamyl-His-Pro-Gly-NH2 + H2O - Bos taurus pyroglutamate + His-Pro-Gly-NH2 - ? 74093 3.4.19.3 pyroglutamyl-Ile + H2O - Bacillus amyloliquefaciens pyroglutamate + Ile - ? 74120 3.4.19.3 pyroglutamyl-Leu + H2O - Bacillus amyloliquefaciens pyroglutamate + Leu - ? 74118 3.4.19.3 pyroglutamyl-Lys + H2O - Bacillus amyloliquefaciens pyroglutamate + Lys - ? 74131 3.4.19.3 pyroglutamyl-Met + H2O - Bacillus amyloliquefaciens pyroglutamate + Met - ? 74126 3.4.19.3 pyroglutamyl-p-nitroanilide + H2O - Gallus gallus pyroglutamate + p-nitroaniline - ? 74111 3.4.19.3 pyroglutamyl-p-nitroanilide + H2O - Streptococcus pyogenes pyroglutamate + p-nitroaniline - ? 74111 3.4.19.3 pyroglutamyl-peptide + H2O the enzyme is able to specifically remove the amino-terminal pyroglutamyl residue protecting proteins or peptides from aminopeptidases Bacillus amyloliquefaciens pyroglutamate + peptide - ? 370664 3.4.19.3 pyroglutamyl-Phe + H2O - Bacillus amyloliquefaciens pyroglutamate + Phe - ? 74121 3.4.19.3 pyroglutamyl-Phe-Pro-NH2 + H2O - Bos taurus pyroglutamate + Phe-Pro-NH2 - ? 74090 3.4.19.3 pyroglutamyl-Ser + H2O - Bacillus amyloliquefaciens pyroglutamate + Ser - ? 74125 3.4.19.3 pyroglutamyl-Thr + H2O - Bacillus amyloliquefaciens pyroglutamate + Thr - ? 74124 3.4.19.3 pyroglutamyl-Trp + H2O - Bacillus amyloliquefaciens pyroglutamate + Trp - ? 74122 3.4.19.3 pyroglutamyl-Tyr + H2O - Bacillus amyloliquefaciens pyroglutamate + Tyr - ? 74123 3.4.19.3 pyroglutamyl-Val + H2O - Bacillus amyloliquefaciens pyroglutamate + Val - ? 74116 3.4.19.3 thyroliberin + H2O - Cavia porcellus pyroglutamate + His-Pro-NH2 - ? 74087 3.4.19.3 thyroliberin + H2O - Mus musculus pyroglutamate + His-Pro-NH2 - ? 74087 3.4.19.3 thyroliberin + H2O - Homo sapiens pyroglutamate + His-Pro-NH2 - ? 74087 3.4.19.3 thyroliberin + H2O - Rattus norvegicus pyroglutamate + His-Pro-NH2 - ? 74087 3.4.19.3 thyroliberin + H2O - Bos taurus pyroglutamate + His-Pro-NH2 - ? 74087 3.4.19.3 thyroliberin + H2O removes the N-terminal pyroglutamic acid Cavia porcellus pyroglutamate + His-Pro-NH2 - ? 74087 3.4.19.3 thyroliberin + H2O i.e. pyroglutamyl-His-Pro-NH2, i.e. thyrotrophin releasing hormone Cavia porcellus pyroglutamate + His-Pro-NH2 - ? 74087 3.4.19.3 thyroliberin-releasing hormone + H2O - Bacillus amyloliquefaciens ? - ? 74097 3.4.19.3 thyrotrophin releasing hormone - Rattus norvegicus ? - ? 369708 3.4.19.3 thyrotrophin releasing hormone the enzyme is proposed to inactivate thyrotrophin releasing hormone in brain extracellular space Mus musculus ? - ? 369708 3.4.19.3 thyrotrophin-releasing hormone + H2O trypanosomal pyroglutamyl aminopeptidase I is responsible for the abnormally rapid degradation of thyrotrophin-releasing hormone in the circulation of infected rats Trypanosoma brucei brucei ? - ? 383382 3.4.19.3 thyrotrophin-releasing hormone + H2O hydrolyzed exclusively at the pyroglutamyl-/-Xaa bond Trypanosoma brucei brucei ? - ? 383382 3.4.19.3 thyrotropin-releasing hormone + H2O - Rattus norvegicus ? - ? 65047 3.4.19.3 thyrotropin-releasing hormone + H2O - Homo sapiens ? - ? 65047 3.4.19.3 thyrotropin-releasing hormone + H2O - Mus musculus ? - ? 65047