3.4.11.7 alpha-L-Asp-2-naphthylamide + H2O - Mus musculus L-Asp + 2-naphthylamine - ? 372338 3.4.11.7 alpha-L-Asp-Val-angiotensin II + H2O - Homo sapiens Asp + Val-angiotensin II - ? 36341 3.4.11.7 alpha-L-aspartate-beta-naphthylamide + H2O high activity Mus musculus L-aspartate + beta-naphthylamine - ? 449548 3.4.11.7 alpha-L-Glu-2-naphthylamide + H2O - Mus musculus alpha-L-Glu + 2-naphthylamine - ? 372347 3.4.11.7 alpha-L-Glu-beta-naphthylamide + H2O - Mus musculus L-Glu + 2-naphthylamine - ? 372348 3.4.11.7 alpha-L-glutamyl-beta-naphthylamide + H2O best substrate Mus musculus L-glutamine + beta-naphthylamine - ? 449549 3.4.11.7 angiotensin I + H2O cleavage only in vitro Mus musculus ? - ? 16449 3.4.11.7 angiotensin I + H2O cleavage only in vitro Homo sapiens ? - ? 16449 3.4.11.7 angiotensin I + H2O cleavage only in vitro Rattus norvegicus ? - ? 16449 3.4.11.7 angiotensin I + H2O cleavage only in vitro Sus scrofa ? - ? 16449 3.4.11.7 angiotensin I + H2O - Canis lupus familiaris Asp + Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu - ? 36339 3.4.11.7 angiotensin II - Mus musculus Asp + Arg-Val-Tyr-Ile-His-Pro-Phe - ? 36340 3.4.11.7 angiotensin II + H2O - Mus musculus ? - ? 16269 3.4.11.7 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus Asp + angiotensin III i.e. Arg-Val-Tyr-Ile-His-Pro-Phe ir 94901 3.4.11.7 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Homo sapiens Asp + angiotensin III i.e. Arg-Val-Tyr-Ile-His-Pro-Phe ir 94901 3.4.11.7 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus Asp + angiotensin III i.e. Arg-Val-Tyr-Ile-His-Pro-Phe ir 94901 3.4.11.7 angiotensin II + H2O i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Sus scrofa Asp + angiotensin III i.e. Arg-Val-Tyr-Ile-His-Pro-Phe ir 94901 3.4.11.7 angiotensin II + H2O angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure Rattus norvegicus Asp + angiotensin III - ? 94901 3.4.11.7 angiotensin II + H2O angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in regulation of blood pressure in the brain Homo sapiens Asp + angiotensin III - ? 94901 3.4.11.7 angiotensin II + H2O angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in renal development Mus musculus Asp + angiotensin III - ? 94901 3.4.11.7 angiotensin II + H2O aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure Rattus norvegicus Asp + angiotensin III - ? 94901 3.4.11.7 angiotensin II + H2O i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus Asp + angiotensin III i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe ? 94901 3.4.11.7 angiotensin II + H2O i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe Homo sapiens Asp + angiotensin III i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe ? 94901 3.4.11.7 angiotensin II + H2O i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus Asp + angiotensin III i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe ? 94901 3.4.11.7 angiotensin II + H2O the enzyme is responsible for the convertion of angiotensin II into angiotensin III in the brain Mus musculus Asp + angiotensin III - ? 94901 3.4.11.7 angiotensin II + H2O angiotensin is the most active compound of the renin-angiotensin-system, RAS, involved in renal development Mus musculus BALB/c Asp + angiotensin III - ? 94901 3.4.11.7 angiotensin II + H2O i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus BALB/c Asp + angiotensin III i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe ? 94901 3.4.11.7 angiotensin II + H2O - Homo sapiens aspartic acid + angiotensin III - ? 393935 3.4.11.7 angiotensin II + H2O - Mus musculus aspartic acid + angiotensin III - ? 393935 3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ? 393935 3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Homo sapiens aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ? 393935 3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ? 393935 3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus aspartic acid + angiotensin III angiotensin III: Arg-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe ? 393935 3.4.11.7 angiotensin II + H2O - Rattus norvegicus L-Asp + angiotensin III - ? 404317 3.4.11.7 angiotensin II + H2O - Mus musculus L-aspartic acid + angiotensin III - ? 404318 3.4.11.7 angiotensin II + H2O - Homo sapiens L-aspartic acid + angiotensin III - ? 404318 3.4.11.7 angiotensin II + H2O - Mus musculus angiotensin III + L-Asp - ? 448448 3.4.11.7 angiotensin II + H2O - Rattus norvegicus angiotensin III + L-Asp - ? 448448 3.4.11.7 angiotensin II + H2O - Mus musculus C57BL/6 angiotensin III + L-Asp - ? 448448 3.4.11.7 angiotensin II + H2O - Rattus norvegicus Wistar angiotensin III + L-Asp - ? 448448 3.4.11.7 angiotensin II + H2O - Rattus norvegicus Wistar-Kyoto angiotensin III + L-Asp - ? 448448 3.4.11.7 angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension Mus musculus angiotensin IV + Arg - ir 380470 3.4.11.7 angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension Homo sapiens angiotensin IV + Arg - ir 380470 3.4.11.7 angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension Rattus norvegicus angiotensin IV + Arg - ir 380470 3.4.11.7 angiotensin III + H2O the enzyme is involved in regulation of blood pressure in the renin-angiotensin system in the brain causing hypertension Sus scrofa angiotensin IV + Arg - ir 380470 3.4.11.7 angiotensin III + H2O i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe, low activity in absence of Ca2+ Homo sapiens ? + angiotensin IV - ? 381421 3.4.11.7 Asp-4-methylcoumaryl-7-amide + H2O low activity in absence and presence of Ca2+ Homo sapiens Asp + 7-amino-4-methylcoumarin - ? 381445 3.4.11.7 Asp-4-nitroanilide + H2O - Glycine max Asp + 4-nitroaniline - ? 364810 3.4.11.7 Asp-7-amido-4-methylcoumarin + H2O assay for measuring aspartyl aminopeptidase activity Plasmodium falciparum Asp + 7-amino-4-methylcoumarin - ? 391321 3.4.11.7 Asp-Ala + H2O - Lactococcus lactis Asp + Ala - ? 94904 3.4.11.7 Asp-Ala + H2O - Lactobacillus delbrueckii subsp. lactis Asp + Ala - ? 94904 3.4.11.7 Asp-Ala + H2O 74% of the activity with Glu-Ala Lactococcus lactis Asp + Ala - ? 94904 3.4.11.7 Asp-Ala + H2O - Lactobacillus delbrueckii subsp. lactis DSM 20072 Asp + Ala - ? 94904 3.4.11.7 Asp-beta-naphthylamide + H2O - Homo sapiens Asp + naphthylamine - ? 36337 3.4.11.7 Asp-beta-naphthylamide + H2O - Sus scrofa Asp + naphthylamine - ? 36337 3.4.11.7 Asp-beta-naphthylamide + H2O dog kidney enzyme 3 times more active compared to Glu-beta-naphthylamide Canis lupus familiaris Asp + naphthylamine - ? 36337 3.4.11.7 Asp-Phe-NH2 + H2O - Staphylococcus chromogenes Asp + Phe + NH3 - ? 36342 3.4.11.7 aspartame + H2O - Staphylococcus chromogenes L-Asp + L-Phe methyl ester - ? 36343 3.4.11.7 cholecystokinin-8 + H2O - Mus musculus ? - ? 64952 3.4.11.7 cholecystokinin-8 + H2O i.e. CCK8 Homo sapiens ? - ? 64952 3.4.11.7 cholecystokinin-8 + H2O cleavage only in vitro Mus musculus ? - ? 64952 3.4.11.7 cholecystokinin-8 + H2O cleavage only in vitro Homo sapiens ? - ? 64952 3.4.11.7 cholecystokinin-8 + H2O cleavage only in vitro Rattus norvegicus ? - ? 64952 3.4.11.7 cholecystokinin-8 + H2O cleavage only in vitro Sus scrofa ? - ? 64952 3.4.11.7 cholecystokinin-8 + H2O CCK8 Homo sapiens ? - ? 64952 3.4.11.7 cholecystokinin-8 + H2O i.e. CCK8 or DYMGWMDF-NH2 Homo sapiens Asp + YMGWMDF-NH2 - ? 381656 3.4.11.7 cholecystokinin-8 + H2O - Rattus norvegicus L-Asp + YMGWMDF-NH2 - ? 404661 3.4.11.7 chromogranin A + H2O - Homo sapiens ? - ? 380576 3.4.11.7 chromogranin A + H2O i.e. EEEEEMAVVPQGLFRG-NH2 Homo sapiens Glu + EEEEMAVVPQGLFRG-NH2 - ? 381681 3.4.11.7 Gln-4-methylcoumaryl-7-amide + H2O low activity in absence and presence of Ca2+ Homo sapiens Gln + 7-amino-4-methylcoumarin - ? 381958 3.4.11.7 Glu-2-naphthylamide + H2O synthetic substrate used in the activity assay Mus musculus Glu + 2-naphthylamine - ? 394334 3.4.11.7 Glu-2-naphthylamide + H2O synthetic substrate used in the activity assay Rattus norvegicus Glu + 2-naphthylamine - ? 394334 3.4.11.7 Glu-4-methylcoumaryl-7-amide + H2O - Crotalus atrox Glu + 7-amino-4-methylcoumarin - ? 381959 3.4.11.7 Glu-4-methylcoumaryl-7-amide + H2O low activity in absence of Ca2+ Homo sapiens Glu + 7-amino-4-methylcoumarin - ? 381959 3.4.11.7 Glu-4-nitroanilide + H2O - Glycine max Glu + 4-nitroaniline - ? 364802 3.4.11.7 Glu-4-nitroanilide + H2O - Streptococcus pneumoniae Glu + 4-nitroaniline - ? 364802 3.4.11.7 Glu-7-amido-4-methylcoumarin + H2O - Mus musculus Glu + 7-amino-4-methylcoumarin - ? 392085 3.4.11.7 Glu-7-amido-4-methylcoumarin + H2O - Rattus norvegicus Glu + 7-amino-4-methylcoumarin - ? 392085 3.4.11.7 Glu-7-amido-4-methylcoumarin + H2O - Gloydius brevicaudus Glu + 7-amino-4-methylcoumarin - ? 392085 3.4.11.7 Glu-7-amido-4-methylcoumarin + H2O activity assay Homo sapiens Glu + 7-amino-4-methylcoumarin - ? 392085 3.4.11.7 Glu-7-amido-4-methylcoumarin + H2O assay for measuring aspartyl aminopeptidase activity Plasmodium falciparum Glu + 7-amino-4-methylcoumarin - ? 392085 3.4.11.7 Glu-Ala + H2O - Lactococcus lactis Glu + Ala - ? 64996 3.4.11.7 Glu-Ala + H2O - Lactobacillus delbrueckii subsp. lactis Glu + Ala - ? 64996 3.4.11.7 Glu-Ala + H2O high activity Lactococcus lactis Glu + Ala - ? 64996 3.4.11.7 Glu-Ala + H2O - Lactobacillus delbrueckii subsp. lactis DSM 20072 Glu + Ala - ? 64996 3.4.11.7 Glu-beta-naphthylamide + H2O - Gallus gallus Glu + naphthylamine - ? 36336 3.4.11.7 Glu-beta-naphthylamide + H2O - Mus musculus Glu + naphthylamine - ? 36336 3.4.11.7 Glu-beta-naphthylamide + H2O - Homo sapiens Glu + naphthylamine - ? 36336 3.4.11.7 Glu-beta-naphthylamide + H2O - Sus scrofa Glu + naphthylamine - ? 36336 3.4.11.7 Glu-beta-naphthylamide + H2O aminopeptidase A six times more active compared to Asp-beta-naphthylamide Canis lupus familiaris Glu + naphthylamine - ? 36336 3.4.11.7 Glu-Glu + H2O many Glu-Xxx and Asp-Xxx dipeptides are substrates Glycine max 2 Glu - ? 418678 3.4.11.7 Glu-Gly + H2O - Lactobacillus delbrueckii subsp. lactis Glu + Gly - ? 449973 3.4.11.7 Glu-Gly + H2O - Lactobacillus delbrueckii subsp. lactis DSM 20072 Glu + Gly - ? 449973 3.4.11.7 Glu-p-nitroanilide + H2O - Homo sapiens Glu + p-nitroaniline - ? 36338 3.4.11.7 Glu-p-nitroanilide + H2O - Sus scrofa Glu + p-nitroaniline - ? 36338 3.4.11.7 Glu-p-nitroanilide + H2O - Oryctolagus cuniculus Glu + p-nitroaniline - ? 36338 3.4.11.7 Glu-p-nitroanilide + H2O - Pseudomonas aeruginosa Glu + p-nitroaniline - ? 36338 3.4.11.7 Glu-p-nitroanilide + H2O - Acinetobacter calcoaceticus Glu + p-nitroaniline - ? 36338 3.4.11.7 Glu-p-nitroanilide + H2O activity assay, cleaved p-nitroanilide is measured Homo sapiens Glu + p-nitroaniline - ? 36338 3.4.11.7 Glu-p-nitroanilide + H2O - Acinetobacter calcoaceticus 69-V Glu + p-nitroaniline - ? 36338 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Latilactobacillus curvatus Glu + 4-nitroaniline - ? 394336 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Latilactobacillus curvatus DBPZ1009 Glu + 4-nitroaniline - ? 394336 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Lactiplantibacillus plantarum glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Leuconostoc mesenteroides glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Lactiplantibacillus pentosus glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Lactiplantibacillus paraplantarum glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Weissella cibaria glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Lactiplantibacillus plantarum DBPZ0987 glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Lactiplantibacillus paraplantarum DBPZ0997 glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Leuconostoc mesenteroides DBPZ0985 glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Glu-p-nitroanilide + H2O peptidase activity assay Lactiplantibacillus pentosus DBPZ0984 glutamic acid + p-nitroaniline - ? 394337 3.4.11.7 Gly-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum Gly + 7-amino-4-methylcoumarin - ? 405296 3.4.11.7 kallidin + H2O - Homo sapiens ? - ? 380633 3.4.11.7 kallidin + H2O i.e. Lys-bradykinin or KRPPGFSPFR, the reaction is performed only in absence of Ca2+ Homo sapiens Lys + bradykinin i.e. RPPGFSPFR ? 382085 3.4.11.7 L-Ala-4-methylcoumaryl-7-amide + H2O about 50% of the activity with L-Glu-4-methylcoumaryl-7-amide Mycoplasma hyopneumoniae L-Ala + 7-amino-4-methylcoumarin - ? 431979 3.4.11.7 L-Ala-4-methylcoumaryl-7-amide + H2O about 50% of the activity with L-Glu-4-methylcoumaryl-7-amide Mycoplasma hyopneumoniae ATCC 25934 L-Ala + 7-amino-4-methylcoumarin - ? 431979 3.4.11.7 L-Ala-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum L-Ala + 7-amino-4-methylcoumarin - ? 364756 3.4.11.7 L-alanine-beta-naphthylamide + H2O low activity Mus musculus L-alanine + beta-naphthylamine - ? 450130 3.4.11.7 L-Arg-2-naphthylamide + H2O - Rattus norvegicus L-Arg + 2-naphthylamine - ? 36317 3.4.11.7 L-Arg-2-naphthylamide + H2O - Oncorhynchus mykiss L-Arg + 2-naphthylamine - ? 36317 3.4.11.7 L-Arg-2-naphthylamide + H2O - Sparus aurata L-Arg + 2-naphthylamine - ? 36317 3.4.11.7 L-Arg-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum L-Arg + 7-amino-4-methylcoumarin - ? 382105 3.4.11.7 L-Asp-4-nitroanilide + H2O - Lactococcus lactis ssp. lactis L-Asp + 4-nitroaniline - ? 94950 3.4.11.7 L-Asp-4-nitroanilide + H2O - Lactobacillus delbrueckii subsp. lactis L-Asp + 4-nitroaniline - ? 94950 3.4.11.7 L-Asp-4-nitroanilide + H2O - Lactobacillus delbrueckii subsp. lactis DSM 20072 L-Asp + 4-nitroaniline - ? 94950 3.4.11.7 L-Asp-4-nitroanilide + H2O - Lactococcus lactis ssp. lactis DSM 20481 L-Asp + 4-nitroaniline - ? 94950 3.4.11.7 L-Asp-peptide + H2O - Gallus gallus L-Asp + peptide - ? 36333 3.4.11.7 L-Asp-peptide + H2O - Lactococcus lactis L-Asp + peptide - ? 36333 3.4.11.7 L-Asp-peptide + H2O free gamma-carboxyl group of N-terminal amino acid essential Lactococcus cremoris L-Asp + peptide - ? 36333 3.4.11.7 L-Asp-peptide + H2O specificity for di- and tri-peptides with Asp or Glu at N-terminal end Sus scrofa L-Asp + peptide - ? 36333 3.4.11.7 L-aspartate-beta-naphthylamide + H2O - Lactobacillus delbrueckii subsp. lactis L-aspartate + beta-naphthylamine - ? 450146 3.4.11.7 L-Glu-2-naphthylamide + H2O - Mus musculus L-Glu + 2-naphthylamine - ? 373296 3.4.11.7 L-Glu-2-naphthylamide + H2O - Homo sapiens L-Glu + 2-naphthylamine - ? 373296 3.4.11.7 L-Glu-4-methylcoumaryl-7-amide + H2O - Mycoplasma hyopneumoniae L-Glu + 7-amino-4-methylcoumarin - ? 432014 3.4.11.7 L-Glu-4-methylcoumaryl-7-amide + H2O - Mycoplasma hyopneumoniae ATCC 25934 L-Glu + 7-amino-4-methylcoumarin - ? 432014 3.4.11.7 L-Glu-4-nitroanilide + H2O - Lactococcus lactis ssp. lactis L-Glu + 4-nitroaniline - ? 382123 3.4.11.7 L-Glu-4-nitroanilide + H2O - Lactobacillus delbrueckii subsp. lactis L-Glu + 4-nitroaniline - ? 382123 3.4.11.7 L-Glu-4-nitroanilide + H2O - Lactobacillus delbrueckii subsp. lactis DSM 20072 L-Glu + 4-nitroaniline - ? 382123 3.4.11.7 L-Glu-4-nitroanilide + H2O - Lactococcus lactis ssp. lactis DSM 20481 L-Glu + 4-nitroaniline - ? 382123 3.4.11.7 L-Glu-7-amido-4-methylcoumarin + H2O - Homo sapiens L-Glu + 7-amino-4-methylcoumarin - ? 405587 3.4.11.7 L-Glu-7-amido-4-methylcoumarin + H2O - Gloydius blomhoffii L-Glu + 7-amino-4-methylcoumarin - ? 405587 3.4.11.7 L-Glu-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum L-Glu + 7-amino-4-methylcoumarin - ? 405587 3.4.11.7 L-Glu-beta-naphthylamide + H2O - Homo sapiens L-Glu + beta-naphthylamine - ? 450155 3.4.11.7 L-Glu-p-nitroanilide + H2O - Mus musculus L-Glu + p-nitroaniline - ? 405590 3.4.11.7 L-Glu-peptide + H2O - Gallus gallus L-Glu + peptide - ? 36334 3.4.11.7 L-Glu-peptide + H2O - Lactococcus lactis L-Glu + peptide - ? 36334 3.4.11.7 L-Glu-peptide + H2O specificity for di-and tripeptides with Asp or Glu at N-terminal end Sus scrofa L-Glu + peptide - ? 36334 3.4.11.7 L-glutamic acid gamma-2-naphthylamide + H2O - Rattus norvegicus L-glutamate + 2-naphthylamide - ? 450159 3.4.11.7 L-glutamic acid gamma-2-naphthylamide + H2O - Rattus norvegicus Wistar L-glutamate + 2-naphthylamide - ? 450159 3.4.11.7 L-glutamyl beta-naphthylamide + H2O - Mus musculus L-Glu + beta-naphthylamine - ? 450160 3.4.11.7 L-glutamyl beta-naphthylamide + H2O - Mus musculus C57BL/6 L-Glu + beta-naphthylamine - ? 450160 3.4.11.7 L-glutamyl-beta-naphthylamide + H2O - Lactobacillus delbrueckii subsp. lactis L-glutamine + beta-naphthylamine - ? 450161 3.4.11.7 L-Leu-4-methylcoumaryl-7-amide + H2O - Mycoplasma hyopneumoniae L-Leu + 7-amino-4-methylcoumarin about 20% of the activity with L-Glu-4-methylcoumaryl-7-amide ? 432033 3.4.11.7 L-Leu-4-methylcoumaryl-7-amide + H2O - Mycoplasma hyopneumoniae ATCC 25934 L-Leu + 7-amino-4-methylcoumarin about 20% of the activity with L-Glu-4-methylcoumaryl-7-amide ? 432033 3.4.11.7 L-Leu-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum L-Leu + 7-amino-4-methylcoumarin - ? 364753 3.4.11.7 L-lysine-beta-naphthylamide + H2O low activity Mus musculus L-lysine + beta-naphthylamine - ? 450177 3.4.11.7 L-Phe-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum L-Phe + 7-amino-4-methylcoumarin - ? 382153 3.4.11.7 L-Pro-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum L-Pro + 7-amino-4-methylcoumarin - ? 392405 3.4.11.7 L-Tyr-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum L-Tyr + 7-amino-4-methylcoumarin - ? 382185 3.4.11.7 L-Val-7-amido-4-methylcoumarin + H2O - Thermoplasma acidophilum L-Val + 7-amino-4-methylcoumarin - ? 405676 3.4.11.7 Leu-7-amido-4-methylcoumarin + H2O assay for measuring aspartyl aminopeptidase activity Plasmodium falciparum Leu + 7-amino-4-methylcoumarin - ? 361386 3.4.11.7 milk proteins + H2O - Lactococcus cremoris ? - ? 369615 3.4.11.7 additional information - Staphylococcus chromogenes ? - ? 89 3.4.11.7 additional information slow hydrolysis of Ala-beta-naphthylamide, Arg-beta-naphthylamide Homo sapiens ? - ? 89 3.4.11.7 additional information association between elevated BP-1 expression and cell growth. The enzyme is not involved in immune system development Mus musculus ? - ? 89 3.4.11.7 additional information the S1' subsite is hydrophobic whereas the S2' subsite recognizes preferentially negatively charged residues derived from aspartic acid Mus musculus ? - ? 89 3.4.11.7 additional information administration of purified enzyme into hypertensive rats leads to a decrease in blood pressure, while enzyme inhibition increases blood pressure Rattus norvegicus ? - ? 89 3.4.11.7 additional information potential biological functions, overview Lactococcus lactis ? - ? 89 3.4.11.7 additional information potential biological functions, overview Streptococcus pneumoniae ? - ? 89 3.4.11.7 additional information potential biological functions, overview Streptococcus pyogenes ? - ? 89 3.4.11.7 additional information potential biological functions, overview Leuconostoc mesenteroides ? - ? 89 3.4.11.7 additional information potential biological functions, overview Streptococcus agalactiae ? - ? 89 3.4.11.7 additional information potential biological functions, overview Streptococcus mutans ? - ? 89 3.4.11.7 additional information potential biological functions, overview Streptococcus suis ? - ? 89 3.4.11.7 additional information The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of the enzyme Mus musculus ? - ? 89 3.4.11.7 additional information the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Mus musculus ? - ? 89 3.4.11.7 additional information the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Homo sapiens ? - ? 89 3.4.11.7 additional information the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Rattus norvegicus ? - ? 89 3.4.11.7 additional information the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides, the enzyme is involved in metabolism of angiotensin II and angiotensin III in the brain, overview Sus scrofa ? - ? 89 3.4.11.7 additional information the enzyme is involved in angiotensin metabolism Mus musculus ? - ? 89 3.4.11.7 additional information the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview Mus musculus ? - ? 89 3.4.11.7 additional information the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview Rattus norvegicus ? - ? 89 3.4.11.7 additional information substrate specificity in presence or absence of Ca2+ Homo sapiens ? - ? 89 3.4.11.7 additional information substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides Mus musculus ? - ? 89 3.4.11.7 additional information substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides Homo sapiens ? - ? 89 3.4.11.7 additional information substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides Rattus norvegicus ? - ? 89 3.4.11.7 additional information substrate specificity, overview, the enzyme catalyses the hydrolysis of N-terminal glutamic or aspartic acid residues from regulatory peptides Sus scrofa ? - ? 89 3.4.11.7 additional information the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives Cavia porcellus ? - ? 89 3.4.11.7 additional information the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives Rattus norvegicus ? - ? 89 3.4.11.7 additional information the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives Mus musculus ? - ? 89 3.4.11.7 additional information the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates Streptococcus pneumoniae ? - ? 89 3.4.11.7 additional information the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates Streptococcus pyogenes ? - ? 89 3.4.11.7 additional information the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates Leuconostoc mesenteroides ? - ? 89 3.4.11.7 additional information the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates Streptococcus agalactiae ? - ? 89 3.4.11.7 additional information the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates Streptococcus mutans ? - ? 89 3.4.11.7 additional information the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates Streptococcus suis ? - ? 89 3.4.11.7 additional information the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates, no activity with Glu-substrate with a blocked N-terminus Lactococcus lactis ? - ? 89 3.4.11.7 additional information enzyme APA cleaves the N-terminal glutamyl or aspartyl residue from peptide substrates Mus musculus ? - ? 89 3.4.11.7 additional information the wild-type enzyme has a high specificity for N-terminal Asp and Glu. Enzyme specificities of the enzyme-metal variants with different substrates, overview Lactobacillus delbrueckii subsp. lactis ? - ? 89 3.4.11.7 additional information the wild-type enzyme has a high specificity for N-terminal Asp and Glu. Enzyme specificities of the enzyme-metal variants with different substrates, overview Lactobacillus delbrueckii subsp. lactis DSM 20072 ? - ? 89 3.4.11.7 N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O - Mus musculus ? - ? 382329 3.4.11.7 N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O - Homo sapiens ? - ? 382329 3.4.11.7 N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O - Rattus norvegicus ? - ? 382329 3.4.11.7 N-(alpha-L-Ala-L-Leu-L-Lys-Arg)-2-naphthylamide + H2O - Sus scrofa ? - ? 382329 3.4.11.7 N-(alpha-L-aspartyl)-2-naphthylamide + H2O - Homo sapiens L-aspartic acid + 2-naphthylamine - ? 382330 3.4.11.7 N-(alpha-L-aspartyl)-2-naphthylamide + H2O - Rattus norvegicus L-aspartic acid + 2-naphthylamine - ? 382330 3.4.11.7 N-(alpha-L-aspartylyl)-2-naphthylamide + H2O - Mus musculus L-aspartic acid + 2-naphthylamine - ? 382332 3.4.11.7 N-(alpha-L-aspartylyl)-2-naphthylamide + H2O - Homo sapiens L-aspartic acid + 2-naphthylamine - ? 382332 3.4.11.7 N-(alpha-L-aspartylyl)-2-naphthylamide + H2O - Rattus norvegicus L-aspartic acid + 2-naphthylamine - ? 382332 3.4.11.7 N-(alpha-L-aspartylyl)-2-naphthylamide + H2O - Sus scrofa L-aspartic acid + 2-naphthylamine - ? 382332 3.4.11.7 N-(alpha-L-glutamyl)-2-naphthylamide + H2O - Mus musculus L-glutamic acid + 2-naphthylamine - ? 382333 3.4.11.7 N-(alpha-L-glutamyl)-2-naphthylamide + H2O - Homo sapiens L-glutamic acid + 2-naphthylamine - ? 382333 3.4.11.7 N-(alpha-L-glutamyl)-2-naphthylamide + H2O - Rattus norvegicus L-glutamic acid + 2-naphthylamine - ? 382333 3.4.11.7 N-(alpha-L-glutamyl)-2-naphthylamide + H2O - Sus scrofa L-glutamic acid + 2-naphthylamine - ? 382333 3.4.11.7 N-(alpha-L-glutamyl)-4-nitroanilide + H2O - Cavia porcellus L-glutamic acid + 4-nitroaniline - ? 382334 3.4.11.7 N-(alpha-L-glutamyl)-4-nitroanilide + H2O - Mus musculus L-glutamic acid + 4-nitroaniline - ? 382334 3.4.11.7 N-(alpha-L-glutamyl)-4-nitroanilide + H2O - Rattus norvegicus L-glutamic acid + 4-nitroaniline - ? 382334 3.4.11.7 N-(alpha-L-glutamyl)-beta-naphthylamide + H2O - Cavia porcellus L-glutamic acid + beta-naphthylamine - ? 382335 3.4.11.7 N-(alpha-L-glutamyl)-beta-naphthylamide + H2O - Rattus norvegicus L-glutamic acid + beta-naphthylamine - ? 382335 3.4.11.7 N-(alpha-L-glutamyl)-beta-naphthylamide + H2O - Mus musculus L-glutamic acid + beta-naphthylamine - ? 382335 3.4.11.7 N-Glu-L-Phe-4-nitroanilide + H2O - Lactococcus cremoris L-Glu + L-Phe-4-nitroanilide - ? 36335 3.4.11.7 neurokinin B + H2O - Homo sapiens ? - ? 65392 3.4.11.7 neurokinin B + H2O i.e. DMHDFFVGLM-NH2 Homo sapiens Asp + MHDFFVGLM-NH2 - ? 382416 3.4.11.7 Ser-Ala + H2O - Lactococcus lactis Ser + Ala - ? 36344 3.4.11.7 Ser-Ala + H2O - Lactobacillus delbrueckii subsp. lactis Ser + Ala - ? 36344 3.4.11.7 Ser-Ala + H2O less than 2% of the activity with Glu-Ala Lactococcus lactis Ser + Ala - ? 36344 3.4.11.7 Ser-Ala + H2O - Lactobacillus delbrueckii subsp. lactis DSM 20072 Ser + Ala - ? 36344