3.2.2.6 1,N6-etheno NAD+ + H2O - Homo sapiens epsilon-ADP-ribose + nicotinamide + H+ - ? 415997 3.2.2.6 3-acetylpyridine + adenosine diphosphoribose transglycosylation activity, very poor hydrolytic activity with this substrate Homo sapiens 3-acetylpyridine adenine dinucleotide + phosphate - ? 371809 3.2.2.6 3-acetylpyridine adenine dinucleotide + H2O - Homo sapiens ? - ? 94817 3.2.2.6 3-acetylpyridine hypoxanthine dinucleotide + H2O low activity Homo sapiens ? - ? 94819 3.2.2.6 3-pyridine adenine dinucleotide + H2O - Homo sapiens ? - ? 214544 3.2.2.6 3-pyridinealdehyde hypoxanthine dinucleotide + H2O - Homo sapiens ? - ? 214545 3.2.2.6 3-pyridinealdehyde hypoxanthine dinucleotide + H2O 60% activity compared to the activity with NAD+ Homo sapiens ? - ? 214545 3.2.2.6 alpha-NAD+ + H2O - Homo sapiens ? - ? 214535 3.2.2.6 beta-NAD+ + H2O - Homo sapiens ? - ? 214534 3.2.2.6 beta-NAD+ + H2O beta-NAD+ and NADP+ are hydrolyzed at equal rates Pseudomonas putida KB1 ? - ? 214534 3.2.2.6 cyclic ADP-ribose + H2O - Homo sapiens ? - ? 214541 3.2.2.6 cyclic ADP-ribose + H2O i.e. ADPR activity Homo sapiens adenosine diphosphoribose + ? - ? 372789 3.2.2.6 cyclic ADP-ribose + H2O - Mus musculus ADP-ribose - ? 416804 3.2.2.6 cyclic ADP-ribose + H2O - Rattus norvegicus ADP-D-ribose - ? 430949 3.2.2.6 cyclic ADP-ribose + H2O - Homo sapiens ADP-D-ribose - ? 430949 3.2.2.6 cyclic ADP-ribose + H2O - Mus musculus ADP-D-ribose - ? 430949 3.2.2.6 cyclic ADP-ribose + H2O - Xenopus laevis ADP-D-ribose - ? 430949 3.2.2.6 epsilon-NAD+ + H2O - Homo sapiens ? - ? 214536 3.2.2.6 epsilon-NADP+ + H2O - Homo sapiens ? - ? 214537 3.2.2.6 additional information synthesis of nicotinate adenine dinucleotide phosphate by exchange of nicotinamide for nicotinic acid Rattus norvegicus ? - ? 89 3.2.2.6 additional information the formation of an enzyme-ADP-ribosyl intermediary complex is common to all reaction pathways Homo sapiens ? - ? 89 3.2.2.6 additional information enzyme is involved in the regulation of intracellular concentration of adenosine diphosphoribose Homo sapiens ? - ? 89 3.2.2.6 additional information enzyme may be induced by presence of protein in the culture medium. Low concentrations of sucrose or glucose, 0.1%, casamino acids or some amino acids such as Met, Cys, Phe and Trp strongly repress enzyme synthesis Neurospora crassa ? - ? 89 3.2.2.6 additional information enzyme is multicatalytic, it also catalyzes the synthesis of cyclic ADP-ribose from NAD+ and the hydrolysis to adenosine diphosphoribose Homo sapiens ? - ? 89 3.2.2.6 additional information CD38 is a multifunctional enzyme catalyzing the conversion of NAD(P)+ to three metabolites (cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate and ADP-ribose) Homo sapiens ? - ? 89 3.2.2.6 additional information CD38 is a NAD+-dependent, multifunctional ectoenzyme that cannot only generate cyclic ADP-ribose from NAD+ but also hydrolyze cyclic ADP-ribose to ADP-ribose and transport cyclic ADP-ribose into cells Mus musculus ? - ? 89 3.2.2.6 additional information frog CD38 enzyme shows NAD+ glycohydrolase, ADP-ribosyl cyclase, and cyclic ADP-ribosyl hydrolase activities Xenopus laevis ? - ? 89 3.2.2.6 additional information the enzyme catalyses the hydrolysis of NAD+ into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR) Bos taurus ? - ? 89 3.2.2.6 additional information selectivity in favor of methanolysis by wild-type enzyme and mutant E138A. 1'-Azido ADP-ribose is the reaction product obtained in the presence of azide. the ADP-ribosyl cyclase activity of wild-type bCD38 isminimal Bos taurus ? - ? 89 3.2.2.6 NAD+ - Homo sapiens cyclic ADP-ribose + nicotinamide - ? 214532 3.2.2.6 NAD+ - Rattus norvegicus cyclic ADP-ribose + nicotinamide - ? 214532 3.2.2.6 NAD+ - Saccharomyces cerevisiae cyclic ADP-ribose + nicotinamide - ? 214532 3.2.2.6 NAD+ - Neurospora crassa cyclic ADP-ribose + nicotinamide - ? 214532 3.2.2.6 NAD+ - Mus musculus cyclic ADP-ribose + nicotinamide - ? 214532 3.2.2.6 NAD+ - Xenopus laevis cyclic ADP-ribose + nicotinamide - ? 214532 3.2.2.6 NAD+ + ? i.e. cADPR activity Homo sapiens cyclic ADP-ribose + ? - ? 373996 3.2.2.6 NAD+ + H2O - Homo sapiens ADP-ribose + nicotinamide - ? 371073 3.2.2.6 NAD+ + H2O the cyclization and hydrolysis of NAD(P)+ occur optimally at physiological pH Mus musculus cyclic ADP-ribose + nicotinamide + H+ - ? 417360 3.2.2.6 NAD+ + H2O - Streptomyces griseus ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NAD+ + H2O - Bos taurus ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NAD+ + H2O overall reaction Rattus norvegicus ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NAD+ + H2O overall reaction Homo sapiens ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NAD+ + H2O overall reaction Mus musculus ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NAD+ + H2O overall reaction Xenopus laevis ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NAD+ + H2O bovine CD38/NAD+ glycohydrolase catalyzes the hydrolysis of NAD+ to nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose via a stepwise reaction mechanism Bos taurus ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NAD+ + H2O via a stepwise reaction mechanism Homo sapiens ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NAD+ + H2O via a stepwise reaction mechanism Bos taurus ADP-D-ribose + nicotinamide - ? 431077 3.2.2.6 NADP+ + H2O - Homo sapiens nicotinamide + ADPribose-phosphate - ? 214531 3.2.2.6 NADP+ + H2O - Saccharomyces cerevisiae nicotinamide + ADPribose-phosphate - ? 214531 3.2.2.6 NADP+ + H2O - Ovis aries nicotinamide + ADPribose-phosphate - ? 214531 3.2.2.6 NADP+ + H2O - Streptomyces griseus nicotinamide + ADPribose-phosphate - ? 214531 3.2.2.6 NADP+ + H2O - Pseudomonas putida KB1 nicotinamide + ADPribose-phosphate - ? 214531 3.2.2.6 NADP+ + H2O 80% activity compared to the activity with NAD+ Homo sapiens ADP-ribose-P + nicotinamide - ? 374008 3.2.2.6 NADP+ + nicotinic acid this reaction occurs only in acidic pH Mus musculus nicotinic acid adenine dinucleotide phosphate - ? 417395 3.2.2.6 NGD+ + H2O as effective as substrate as NAD+ Homo sapiens GDP-ribose + nicotinamide - ? 374034 3.2.2.6 NGD+ + H2O - Homo sapiens cyclic GDP-ribose - ? 417407 3.2.2.6 nicotinamide 1,N6-ethenoadenine dinucleotide + H2O i.e. epsilonNAD+, used for a fluorometric assay Homo sapiens ? - ? 374038 3.2.2.6 nicotinamide guanine dinucleotide + H2O - Homo sapiens ? - ? 94836 3.2.2.6 nicotinamide-hypoxanthine dinucleotide + H2O - Homo sapiens ? - ? 214539 3.2.2.6 nicotinamide-hypoxanthine dinucleotide + H2O - Pseudomonas putida KB1 ? - ? 214539 3.2.2.6 nicotinamide-hypoxanthine dinucleotide phosphate + H2O - Pseudomonas putida KB1 ? - ? 214540 3.2.2.6 thio-NAD+ + H2O - Homo sapiens ? - ? 141279 3.2.2.6 thio-NAD+ + H2O - Pseudomonas putida KB1 ? - ? 141279