3.1.3.5 (polyphosphate)n + H2O - Escherichia coli (polyphosphate)n-1 + phosphate - ? 141194 3.1.3.5 (polyphosphate)n + H2O - Escherichia coli (polyphosphate)(n-1) + phosphate - ? 371383 3.1.3.5 1,N6-ethenoadenosine 5'-phosphate + H2O 45% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus 1,N6-ethenoadenosine ribonucleoside + phosphate - ? 73826 3.1.3.5 1-glycerophosphate + H2O 1% of the activity with 5’-IMP Varanus gouldii glycerol + phosphate - ? 380843 3.1.3.5 2'-chloro-2'-deoxyAMP + H2O cNII Homo sapiens 2'-chloro-2'-deoxyadenosine + phosphate - ? 416093 3.1.3.5 2-(cyclohexylethylthio)adenosine 5'-monophosphate + H2O - Rattus norvegicus 2-(cyclohexylethylthio)adenosine + phosphate - ? 411195 3.1.3.5 2-(cyclohexylmethylthio)adenosine 5'-monophosphate + H2O - Rattus norvegicus 2-(cyclohexylmethylthio)adenosine + phosphate - ? 411196 3.1.3.5 2-(cyclohexylthio)adenosine 5'-monophosphate + H2O - Rattus norvegicus 2-(cyclohexylthio)adenosine + phosphate - ? 411197 3.1.3.5 2-(cyclopentylthio)adenosine 5'-monophosphate + H2O - Rattus norvegicus 2-(cyclopentylthio)adenosine + phosphate - ? 411198 3.1.3.5 2-(dioxanylethylthio)adenosine 5'-monophosphate + H2O - Rattus norvegicus 2-(dioxanylethylthio)adenosine + phosphate - ? 411199 3.1.3.5 2-(dioxolanylethylthio)adenosine 5'-monophosphate + H2O - Rattus norvegicus 2-(dioxolanylethylthio)adenosine + phosphate - ? 411200 3.1.3.5 2-(hexylthio)adenosine 5'-monophosphate + H2O - Rattus norvegicus 2-(hexylthio)adenosine + phosphate - ? 411201 3.1.3.5 2-(propylthio)adenosine 5'-monophosphate + H2O - Rattus norvegicus 2-(propylthio)adenosine + phosphate - ? 411202 3.1.3.5 2-chloro-2'-deoxyadenosine monophosphate + H2O 39% of the activity with 5'-AMP Homo sapiens 2-chloro-2'-deoxyadenosine + phosphate - ? 364582 3.1.3.5 3'-AMP + H2O - Escherichia coli adenosine + phosphate - ? 64617 3.1.3.5 3'-azido-3'deoxy-dTMP + H2O cNII Homo sapiens 3'-azido-3'-deoxythymidine + phosphate - ? 416205 3.1.3.5 3'-CMP + H2O - Escherichia coli cytosine + phosphate - ? 73841 3.1.3.5 3'-IMP + H2O 1% of the activity with 5'-IMP Oncorhynchus masou inosine + phosphate - ? 73842 3.1.3.5 3-beta-ribofuranosyladenine 5'-monophosphate + H2O 24% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus 3-beta-ribofuranosyladenine + phosphate - ? 73827 3.1.3.5 4-methylumbelliferyl phosphate + H2O - Helicobacter pylori 4-methylumbelliferol + phosphate - ? 364583 3.1.3.5 4-nitrophenyl phosphate + H2O - Escherichia coli 4-nitrophenol + phosphate - ? 73771 3.1.3.5 4-nitrophenyl phosphate + H2O - Xylella fastidiosa 4-nitrophenol + phosphate - ? 73771 3.1.3.5 4-nitrophenyl phosphate + H2O about 55% of the activity with 4-methylumbelliferyl phosphate Helicobacter pylori 4-nitrophenol + phosphate - ? 73771 3.1.3.5 4-nitrophenyl phosphate + H2O best substrate, very high activity Bacillus subtilis 4-nitrophenol + phosphate - ? 73771 3.1.3.5 4-nitrophenyl phosphate + H2O - Xylella fastidiosa 9a5c 4-nitrophenol + phosphate - ? 73771 3.1.3.5 5'-ADP + H2O very low activity Bacillus subtilis AMP + phosphate - ? 93273 3.1.3.5 5'-AMP + H2O - Gallus gallus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Cavia porcellus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Aliivibrio fischeri adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Mus musculus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Escherichia coli adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Homo sapiens adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Rattus norvegicus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Sus scrofa adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Saccharomyces cerevisiae adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bos taurus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Oryctolagus cuniculus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Neurospora crassa adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Ovis aries adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Zea mays adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Solanum tuberosum adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Giardia intestinalis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Photobacterium phosphoreum adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Photobacterium leiognathi adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Vibrio harveyi adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Proteus vulgaris adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bacillus sp. (in: Bacteria) adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Kocuria varians adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Vibrio parahaemolyticus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Ureaplasma urealyticum adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Candida parapsilosis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Columba livia adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops atrox adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops moojeni adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops marajoensis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Crotalus adamanteus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Crotalus atrox adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Daboia russelii adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Vibrio cholerae serotype O1 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops jararaca adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Torpedo marmorata adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Vibrio alginolyticus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Cajanus cajan adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Rhipicephalus microplus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Sturnus vulgaris adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Salmonella enterica subsp. enterica serovar Heidelberg adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Hemachatus haemachatus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Naja naja adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Shigella sonnei adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Sebastes inermis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Crotalus durissus terrificus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Mycoplasmopsis fermentans adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Danio rerio adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Tritrichomonas suis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Mycoplasma arthritidis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops jararacussu adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Crotalus durissus cascavella adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops alternatus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Lutzomyia longipalpis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Mycoplasmopsis pulmonis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Mycoplasma buccale adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Lachesis muta muta adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops pirajai adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops cotiara adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops neuwiedi adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops pradoi adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Leishmania chagasi adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Dosidicus gigas adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops insularis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops alcatraz adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops brazili adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops diporus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops erythromelas adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops fonsecai adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops itapetiningae adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops matogrossensis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops pauloensis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops pubescens adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bothrops taeniatus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Micrurus frontalis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Crotalus durissus cumanensis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Loxosceles gaucho adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Crotalus durissus collilineatus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Macrovipera lebetina adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O best substrate Homo sapiens adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O best substrate Giardia intestinalis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O best substrate Macrovipera lebetina adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O best substrate Streptococcus pyogenes adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O low activity Bacillus subtilis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O preferred substrate Homo sapiens adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 101% of the activity of 5'-IMP Gadus macrocephalus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O best substrate for enzyme from plasma membrane and Golgi apparatus Arachis hypogaea adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 64% of the activity of ATP Salinivibrio costicola adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 21% of the activity with 5'-IMP Sus scrofa adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O highly specific, no hydrolysis of other nucleotides Arachis hypogaea adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 100% activity Rattus norvegicus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 100% activity Trichomonas gallinae adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 36.3% of the activity with 5'-IMP Oncorhynchus masou adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O about 35% of the activity with 4-methylumbelliferyl phosphate Helicobacter pylori adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O preferred substrate for cNI and eNs Homo sapiens adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O enzyme is responsible for generation of adenosine from AMP. Adenosine is involved in a number of cardioprotective mechanisms. TNF-alpha may reduce the capacity of human endothelial cels to produce adenosine by a decrease in activity of ecto-5'-nucleotidase. The loss of ecto-5'-nucleotidase may lead to decreased production of anti-inflammatory adenosine and retention of proinflammatory nucleotides Homo sapiens adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 17% of the activity with 5’-IMP Crocodylus siamensis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 30% of the activity with 5’-IMP Salvator rufescens adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 32% of the activity with 5’-IMP Varanus gouldii adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O absence of ADP, 60% loss of activity Columba livia adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O enzyme is monospecific for AMP among nucleoside 5’-monophosphates Trichinella spiralis adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O CD73 Homo sapiens adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O most efficiently hydrolyzed substrate Rattus norvegicus adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O low activity Bacillus subtilis 168 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O 100% activity Trichomonas gallinae TG7 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O best substrate Streptococcus pyogenes ATCC 700294 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Bacillus sp. (in: Bacteria) No. A-59 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Mus musculus C57BL/6 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Rattus norvegicus Wistar adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Leishmania chagasi MHOM/BR/1974/PP75 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Candida parapsilosis CCT 3834 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O - Mycoplasmopsis pulmonis NCTC 10139 adenosine + phosphate - ? 64616 3.1.3.5 5'-AMP + H2O the enzyme is responsible for the production of adenosine in the cardiac tissue Rattus norvegicus ? - ? 93414 3.1.3.5 5'-AMP + H2O enzyme in the system for the hydrolysis of extracellular nucleotides so that product nucleosides are readily transported into the cell Escherichia coli ? - ? 93414 3.1.3.5 5'-ATP + H2O very low activity Bacillus subtilis ADP + phosphate - ? 446844 3.1.3.5 5'-CMP + H2O - Gallus gallus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Mus musculus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Homo sapiens cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Rattus norvegicus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Sus scrofa cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Saccharomyces cerevisiae cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Bos taurus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Oryctolagus cuniculus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Neurospora crassa cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Giardia intestinalis cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Vibrio parahaemolyticus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Columba livia cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Cajanus cajan cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Sturnus vulgaris cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Sebastes inermis cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Streptococcus pyogenes cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 116% of the activity with 5'-AMP Zea mays cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 56.2% of the activity with 5'-AMP Kocuria varians cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 48% of the activity with 5'-IMP Sus scrofa cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 93% of the activity with 5'-AMP Mus musculus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 93% of the activity with 5'-AMP Torpedo marmorata cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 23.1% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 87% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 65% of the activity with 5'-AMP, brain cytosolic enzyme Rattus norvegicus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 61.7% of the activity with 5'-AMP Columba livia cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 85% of the activity of 5'-IMP Gadus macrocephalus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 46% of the activity with 5'-AMP Zea mays cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 125% of the activity with 5'-AMP Cavia porcellus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 18.4% of the activity with 5'-IMP Oncorhynchus masou cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 85% of the activity with 5'-AMP Homo sapiens cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O about 30% of the activity with 4-methylumbelliferyl phosphate Helicobacter pylori cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 11% of the activity with 5’-IMP Varanus gouldii cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 17% of the activity with 5’-IMP Salvator rufescens cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 21% of the activity with 5’-IMP Crocodylus siamensis cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 49% of activity with Mg2+-AMP Danio rerio cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 36% dephosphorylation in relation to AMP Rattus norvegicus cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 87% activity compared to 5'-AMP Trichomonas gallinae cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O Sdt1 Saccharomyces cerevisiae cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O CD73 Homo sapiens cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O 87% activity compared to 5'-AMP Trichomonas gallinae TG7 cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + H2O - Streptococcus pyogenes ATCC 700294 cytidine + phosphate - ? 64640 3.1.3.5 5'-CMP + xanthosine - Rattus norvegicus XMP + cytidine - ? 381258 3.1.3.5 5'-CTP + H2O low activity Bacillus subtilis CDP + phosphate - ? 446847 3.1.3.5 5'-dAMP + H2O - Escherichia coli deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O - Homo sapiens deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O - Streptococcus pyogenes deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O low activity Bacillus subtilis deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Cavia porcellus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Mus musculus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Homo sapiens deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Rattus norvegicus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Saccharomyces cerevisiae deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Oryctolagus cuniculus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Neurospora crassa deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Bacillus sp. (in: Bacteria) deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Columba livia deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Torpedo marmorata deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Gadus macrocephalus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 66% of the activity with 5'-AMP Columba livia deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 54% of the activity with 5'-AMP Mus musculus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 22% of the activity with 5'-AMP Cavia porcellus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 20% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 14% of the activity with 5'-AMP Torpedo marmorata deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 53% of the activity of 5'-IMP Gadus macrocephalus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 19.7% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 7% of the activity with 5'-AMP, brain cytosolic enzyme Rattus norvegicus deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O presence of ADP, 66% of the activity with 5’-AMP Columba livia deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O low activity Bacillus subtilis 168 deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O - Streptococcus pyogenes ATCC 700294 deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Bacillus sp. (in: Bacteria) No. A-59 deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dAMP + H2O 19.7% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) No. A-59 deoxyadenosine + phosphate - ? 64620 3.1.3.5 5'-dCMP + H2O - Homo sapiens deoxycytidine + phosphate - ? 64632 3.1.3.5 5'-dCMP + H2O - Escherichia coli deoxycytidine + phosphate - ? 64632 3.1.3.5 5'-dCMP + H2O 28% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus deoxycytidine + phosphate - ? 64632 3.1.3.5 5'-dCMP + H2O i.e. 2'-deoxycytosine 5'-phosphate Homo sapiens deoxycytidine + phosphate - ? 64632 3.1.3.5 5'-dCMP + H2O i.e. 2'-deoxycytosine 5'-phosphate Rattus norvegicus deoxycytidine + phosphate - ? 64632 3.1.3.5 5'-dCMP + H2O i.e. 2'-deoxycytosine 5'-phosphate Oryctolagus cuniculus deoxycytidine + phosphate - ? 64632 3.1.3.5 5'-dCMP + H2O i.e. 2'-deoxycytosine 5'-phosphate Neurospora crassa deoxycytidine + phosphate - ? 64632 3.1.3.5 5'-dCMP + H2O presence of ADP, 16% of the activity with 5’-AMP Columba livia deoxycytidine + phosphate - ? 64632 3.1.3.5 5'-dCMP + H2O - Homo sapiens 2'-deoxycytidine + phosphate - ? 372114 3.1.3.5 5'-dCMP + H2O - Escherichia coli 2'-deoxycytidine + phosphate - ? 372114 3.1.3.5 5'-dCMP + H2O CD73 Homo sapiens 2'-deoxycytidine + phosphate - ? 372114 3.1.3.5 5'-dGMP + H2O - Homo sapiens deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O - Escherichia coli deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O - Legionella pneumophila deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O low activity Bacillus subtilis deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Gallus gallus deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Mus musculus deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Homo sapiens deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Rattus norvegicus deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Oryctolagus cuniculus deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Neurospora crassa deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Columba livia deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O 49.9% of the activity with 5'-AMP Columba livia deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O 35% of the activity with 5'-AMP Mus musculus deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O cNII Homo sapiens deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dGMP + H2O - Legionella pneumophila DSM 7513 deoxyguanosine + phosphate - ? 64635 3.1.3.5 5'-dIMP + H2O - Homo sapiens deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O - Zea mays deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O - Escherichia coli deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O - Crocodylus siamensis deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O - Legionella pneumophila deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O low activity Bacillus subtilis deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O i.e. 2'-deoxyinosine 5'-phosphate Homo sapiens deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O i.e. 2'-deoxyinosine 5'-phosphate Rattus norvegicus deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O i.e. 2'-deoxyinosine 5'-phosphate Columba livia deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O 23% of the activity with 5'-IMP, cytoplasmic enzyme Homo sapiens deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O 60.9% of the activity with 5'-AMP Columba livia deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O 61% of the activity with 5'-AMP Homo sapiens deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O 102% of the activity with 5’-IMP Crocodylus siamensis deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O 95% of the activity with 5’-IMP Salvator rufescens deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O 99% of the activity with 5’-IMP Varanus gouldii deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O presence of ADP, 38% of the activity with 5’-AMP Columba livia deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O cNII Homo sapiens deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dIMP + H2O - Legionella pneumophila DSM 7513 deoxyinosine + phosphate - ? 64636 3.1.3.5 5'-dTMP + H2O - Homo sapiens deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O - Rattus norvegicus deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O - Escherichia coli deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O i.e. 2'-deoxythymidine 5'-phosphate Rattus norvegicus deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O i.e. 2'-deoxythymidine 5'-phosphate Neurospora crassa deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O 55% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O 10% of the activity with 5’-IMP Varanus gouldii deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O 17.5% of the activity with 5’-IMP Salvator rufescens deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O 7.1% of the activity with 5’-IMP Crocodylus siamensis deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dTMP + H2O CD73 Homo sapiens deoxythymidine + phosphate - ? 64629 3.1.3.5 5'-dUMP + H2O - Homo sapiens deoxyuridine + phosphate - ? 64627 3.1.3.5 5'-dUMP + H2O - Escherichia coli deoxyuridine + phosphate - ? 64627 3.1.3.5 5'-dUMP + H2O i.e. 2'-deoxyuridine 5'-phosphate Homo sapiens deoxyuridine + phosphate - ? 64627 3.1.3.5 5'-dUMP + H2O CD73 Homo sapiens deoxyuridine + phosphate - ? 64627 3.1.3.5 5'-GDP + H2O very low activity Bacillus subtilis GMP + phosphate - ? 446855 3.1.3.5 5'-GMP + H2O - Gallus gallus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Mus musculus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Escherichia coli guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Homo sapiens guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Rattus norvegicus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Sus scrofa guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Saccharomyces cerevisiae guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Bos taurus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Oryctolagus cuniculus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Neurospora crassa guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Giardia intestinalis guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Trichomonas vaginalis guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Vibrio parahaemolyticus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Columba livia guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Cajanus cajan guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Sturnus vulgaris guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Sebastes inermis guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Homo sapiens guanosine + phosphate - r 64638 3.1.3.5 5'-GMP + H2O - Macrovipera lebetina guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Streptococcus pyogenes guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O low activity Bacillus subtilis guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O preferred substrate Homo sapiens guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 67% of the activity of ATP Salinivibrio costicola guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 116% of the activity with 5'-AMP Zea mays guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 120% of the activity with 5'-AMP Mus musculus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 53.6% of the activity with 5'-AMP Kocuria varians guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 33.5% of the activity with 5'-AMP Columba livia guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 16.7% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 50% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O plasma membrane enzyme: 2.85% of the activity with 5'-AMP, Golgi apparatus enzyme: 46% of the activity with 5'-AMP Arachis hypogaea guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 19% of the activity with 5'-AMP Rattus norvegicus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 52% of the activity of 5'-IMP Gadus macrocephalus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 52% of the activity with 5'-AMP Torpedo marmorata guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 85% of the activity with 5'-IMP, cytoplasmic enzyme Homo sapiens guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 117% of the activity with 5'-AMP Cavia porcellus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 94% of the activity with 5'-IMP Sus scrofa guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 57% of the activity with 5'-AMP Homo sapiens guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 97.6% of the activity with 5'-IMP Oncorhynchus masou guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O about 30% of the activity with 4-methylumbelliferyl phosphate Helicobacter pylori guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 104% of the activity with 5’-IMP Varanus gouldii guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 107% of activity with Mg2+-AMP Danio rerio guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 89% of the activity with 5’-IMP Crocodylus siamensis guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 99% of the activity with 5’-IMP Salvator rufescens guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 57% dephosphorylation in relation to AMP Rattus norvegicus guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 68% activity compared to 5'-AMP Trichomonas gallinae guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O cNII, CD73 Homo sapiens guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O preferred substrate. Substrate GMP acting as an activator, partitioning between the allosteric and active site, is the basis for the sigmoidicity of the initial velocity versus GMP concentration plot Legionella pneumophila guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 68% activity compared to 5'-AMP Trichomonas gallinae TG7 guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Trichomonas vaginalis ATCC30238 guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Streptococcus pyogenes ATCC 700294 guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O 16.7% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) No. A-59 guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O preferred substrate. Substrate GMP acting as an activator, partitioning between the allosteric and active site, is the basis for the sigmoidicity of the initial velocity versus GMP concentration plot Legionella pneumophila DSM 7513 guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + H2O - Trichomonas vaginalis ATCC 30236 guanosine + phosphate - ? 64638 3.1.3.5 5'-GMP + xanthosine - Rattus norvegicus XMP + guanosine - ? 381260 3.1.3.5 5'-GTP + H2O very low activity Bacillus subtilis GDP + phosphate - ? 446856 3.1.3.5 5'-IDP + H2O very low activity Bacillus subtilis IMP + phosphate - ? 446857 3.1.3.5 5'-IMP + H2O - Gallus gallus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Escherichia coli inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Homo sapiens inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Rattus norvegicus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Sus scrofa inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Saccharomyces cerevisiae inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Bos taurus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Bos taurus inosine + phosphate - r 64634 3.1.3.5 5'-IMP + H2O - Oryctolagus cuniculus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Neurospora crassa inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Giardia intestinalis inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Columba livia inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Cajanus cajan inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Sturnus vulgaris inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Sebastes inermis inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Trachurus japonicus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Oncorhynchus masou inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Triakis scyllium inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Pseudomonas aeruginosa inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Homo sapiens inosine + phosphate - r 64634 3.1.3.5 5'-IMP + H2O - Varanus gouldii inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Salvator rufescens inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Dosidicus gigas inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Legionella pneumophila inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O best substrate Homo sapiens inosine + phosphate - r 64634 3.1.3.5 5'-IMP + H2O low activity Bacillus subtilis inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O preferred substrate Homo sapiens inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O preferred substrate of cytosolic thymus enzyme Bos taurus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O 36% of the activity with 5'-AMP, brain cytosolic enzyme Rattus norvegicus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O 148% of the activity with 5'-AMP Mus musculus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O 33.1% of the activity with 5'-AMP Columba livia inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O 92% of the activity with 5'-AMP Cavia porcellus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O equally reactive as 5'-AMP Gadus macrocephalus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O 63% of the activity with 5'-AMP Torpedo marmorata inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O 55% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O preferred substrate for cNII Homo sapiens inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O 8% of the activity with 5’-IMP Varanus gouldii inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O Isn1 Saccharomyces cerevisiae inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O cNII, CD73 Homo sapiens inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Legionella pneumophila DSM 7513 inosine + phosphate - ? 64634 3.1.3.5 5'-IMP + H2O - Bos taurus ? - ? 93297 3.1.3.5 5'-IMP + H2O the enzyme is principally responsible for dephosphorylation of 5'-IMP but may have some role in adenosine formation Columba livia ? - ? 93297 3.1.3.5 5'-IMP + xanthosine - Rattus norvegicus XMP + inosine - ? 381262 3.1.3.5 5'-inosinic acid + H2O - Crocodylus siamensis ? - ? 452668 3.1.3.5 5'-TMP + H2O - Saccharomyces cerevisiae thymidine + phosphate - ? 73536 3.1.3.5 5'-TMP + H2O - Oryctolagus cuniculus thymidine + phosphate - ? 73536 3.1.3.5 5'-TMP + H2O - Homo sapiens thymidine + phosphate - ? 73536 3.1.3.5 5'-TMP + H2O - Streptococcus pyogenes thymidine + phosphate - ? 73536 3.1.3.5 5'-TMP + H2O 107% of the activity of ATP Salinivibrio costicola thymidine + phosphate - ? 73536 3.1.3.5 5'-TMP + H2O 15.2% of the activity with 5'-AMP Columba livia thymidine + phosphate - ? 73536 3.1.3.5 5'-TMP + H2O 7.4% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) thymidine + phosphate - ? 73536 3.1.3.5 5'-TMP + H2O 13% of the activity with 5'-AMP Homo sapiens thymidine + phosphate - ? 73536 3.1.3.5 5'-TMP + H2O about 15% of the activity with 4-methylumbelliferyl phosphate Helicobacter pylori thymidine + phosphate - ? 73536 3.1.3.5 5'-UMP + H2O - Gallus gallus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Mus musculus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Homo sapiens uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Rattus norvegicus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Saccharomyces cerevisiae uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Bos taurus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Neurospora crassa uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Giardia intestinalis uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Vibrio parahaemolyticus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Columba livia uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Sturnus vulgaris uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Sebastes inermis uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O - Pseudomonas aeruginosa uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O low activity Bacillus subtilis uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 117% of the activity with 5'-AMP Cavia porcellus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 180% of the activity with 5'-AMP, preferred substrate Mus musculus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 33.3% of the activity with 5'-AMP Kocuria varians uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 14% of the activity with 5'-IMP Sus scrofa uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 93% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 83% of the activity of ATP Salinivibrio costicola uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 10.6% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O plasma membrane enzyme: 7.5% of the activity with 5'-AMP, Golgi apparatus enzyme: 16.2% of the activity with 5'-AMP Arachis hypogaea uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 71% of the activity with 5'-AMP Zea mays uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 49.5% of the activity with 5'-AMP Columba livia uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 120% of the activity of 5'-IMP Gadus macrocephalus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 80% of the activity with 5'-AMP Torpedo marmorata uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 14% of the activity with 5'-IMP, cytoplasmic enzyme Homo sapiens uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 137% of the activity with 5'-AMP Zea mays uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 111% of the activity with 5'-AMP, brain cytosolic enzyme Rattus norvegicus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 52.3% of the activity with 5'-IMP Oncorhynchus masou uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 78% of the activity with 5'-AMP Homo sapiens uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O about 30% of the activity with 4-methylumbelliferyl phosphate Helicobacter pylori uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 33% of the activity with 5’-IMP Varanus gouldii uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 41% of the activity with 5’-IMP Crocodylus siamensis uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 56% of the activity with 5’-IMP Salvator rufescens uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 97% of activity with Mg2+-AMP Danio rerio uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 51% dephosphorylation in relation to AMP Rattus norvegicus uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 60% activity compared to 5'-AMP Trichomonas gallinae uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O Sdt1 Saccharomyces cerevisiae uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O CD73 Homo sapiens uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O low activity Bacillus subtilis 168 uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 60% activity compared to 5'-AMP Trichomonas gallinae TG7 uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + H2O 10.6% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) No. A-59 uridine + phosphate - ? 64618 3.1.3.5 5'-UMP + xanthosine - Rattus norvegicus XMP + uridine - ? 381263 3.1.3.5 5'-XMP + H2O - Homo sapiens xanthosine + phosphate - ? 73820 3.1.3.5 5'-XMP + H2O - Rattus norvegicus xanthosine + phosphate - ? 73820 3.1.3.5 5'-XMP + H2O - Cajanus cajan xanthosine + phosphate - ? 73820 3.1.3.5 5'-XMP + H2O 23% of the activity with 5'-IMP, cytoplasmic enzyme Homo sapiens xanthosine + phosphate - ? 73820 3.1.3.5 5'-XMP + H2O third best substrate Bacillus subtilis xanthosine + phosphate - ? 73820 3.1.3.5 5'-XMP + H2O cNII, CD73 Homo sapiens xanthosine + phosphate - ? 73820 3.1.3.5 5-fluoro-dUMP + H2O cNII Homo sapiens 5-fluoro-uridine + phosphate - ? 416437 3.1.3.5 5-phosphoribosyl-1-diphosphate + H2O - Bacillus subtilis ? - ? 446877 3.1.3.5 6-chloropurine ribonucleoside 5'-monophosphate + H2O 50% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus 6-chloropurine ribonucleoside + phosphate - ? 73825 3.1.3.5 7-methylguanosine diphosphate + H2O preferred substrate Homo sapiens 7-methylguanosine monophosphate + phosphate - ? 446900 3.1.3.5 7-methylguanosine monophosphate + H2O preferred substrate Homo sapiens 7-methylguanosine + phosphate - ? 446901 3.1.3.5 9-beta-D-arabinosyl-2-fluoroadenine monophosphate + H2O - Homo sapiens 9-beta-D-arabinosyl-2-fluoroadenine + phosphate - ? 391098 3.1.3.5 a 5'-ribonucleotide + H2O - Homo sapiens a ribonucleoside + phosphate - ? 446084 3.1.3.5 a 5'-ribonucleotide + H2O - Escherichia coli a ribonucleoside + phosphate - ? 446084 3.1.3.5 a 5'-ribonucleotide + H2O - Rattus norvegicus a ribonucleoside + phosphate - ? 446084 3.1.3.5 a 5'-ribonucleotide + H2O - Bacillus subtilis a ribonucleoside + phosphate - ? 446084 3.1.3.5 adenosine 5'-O-thiophosphate + H2O 6% of the activity with 5'-AMP, heart, membrane-bound enzyme Rattus norvegicus ? - ? 73828 3.1.3.5 ADP + 2 H2O - Aliivibrio fischeri adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + 2 H2O - Escherichia coli adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + 2 H2O - Photobacterium phosphoreum adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + 2 H2O - Photobacterium leiognathi adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + 2 H2O - Vibrio harveyi adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + 2 H2O - Vibrio parahaemolyticus adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + 2 H2O - Vibrio cholerae serotype O1 adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + 2 H2O - Vibrio alginolyticus adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + 2 H2O 114% of the activity of ATP Salinivibrio costicola adenosine + 2 phosphate - ? 73811 3.1.3.5 ADP + H2O - Salinivibrio costicola adenosine + diphosphate - ? 73810 3.1.3.5 ADP + H2O - Rhipicephalus microplus adenosine + diphosphate - ? 73810 3.1.3.5 ADP + H2O 4.5% of the activity with 5'-AMP Torpedo marmorata adenosine + diphosphate - ? 73810 3.1.3.5 ADP + H2O 9.6% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) adenosine + diphosphate - ? 73810 3.1.3.5 ADP + H2O - Danio rerio AMP + phosphate - ? 93189 3.1.3.5 ADP + H2O - Macrovipera lebetina 5'-AMP + phosphate - ? 446939 3.1.3.5 ADP + H2O - Streptococcus pyogenes 5'-AMP + phosphate - ? 446939 3.1.3.5 AMP + H2O - Mus musculus adenosine + phosphate - ? 73505 3.1.3.5 AMP + H2O - Rattus norvegicus adenosine + phosphate - ? 73505 3.1.3.5 AMP + H2O - Trichomonas vaginalis adenosine + phosphate - ? 73505 3.1.3.5 AMP + H2O - Danio rerio adenosine + phosphate - ? 73505 3.1.3.5 AMP + H2O - Gloydius brevicaudus adenosine + phosphate - ? 73505 3.1.3.5 AMP + H2O - Homo sapiens adenosine + phosphate - ? 73505 3.1.3.5 AMP + H2O AMP in form of MgAMP Danio rerio adenosine + phosphate - ? 73505 3.1.3.5 ATP + 3 H2O - Aliivibrio fischeri adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + 3 H2O - Escherichia coli adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + 3 H2O - Photobacterium phosphoreum adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + 3 H2O - Photobacterium leiognathi adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + 3 H2O - Vibrio harveyi adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + 3 H2O - Salinivibrio costicola adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + 3 H2O - Vibrio parahaemolyticus adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + 3 H2O - Vibrio cholerae serotype O1 adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + 3 H2O - Vibrio alginolyticus adenosine + 3 phosphate - ? 73814 3.1.3.5 ATP + H2O - Rhipicephalus microplus adenosine + triphosphate - ? 73813 3.1.3.5 ATP + H2O - Danio rerio ADP + phosphate - ? 92967 3.1.3.5 ATP + H2O lowest activity Macrovipera lebetina ADP + phosphate - ? 92967 3.1.3.5 bis-p-nitrophenylphosphate + H2O - Rhipicephalus microplus ? - ? 73815 3.1.3.5 CMP + H2O - Saccharomyces cerevisiae cytidine + phosphate - ? 93282 3.1.3.5 CTP + H2O 30% of the activity with ATP Salinivibrio costicola ? - ? 64642 3.1.3.5 cyclic 3',5'-AMP + H2O 8.8% of the activity with 5'-AMP Bacillus sp. (in: Bacteria) ? - ? 73812 3.1.3.5 D-glucose 6-phosphate + H2O very low activity Bacillus subtilis D-glucose + phosphate - ? 73625 3.1.3.5 D-ribose 5-phosphate + H2O second best substrate Bacillus subtilis D-ribose + phosphate - ? 13179 3.1.3.5 D-ribose 5-phosphate + H2O second best substrate Bacillus subtilis 168 D-ribose + phosphate - ? 13179 3.1.3.5 dAMP + H2O 91% of the activity with 5'-AMP Homo sapiens deoxyadenosine + phosphate - ? 93291 3.1.3.5 dATP + H2O 83% of the activity with ATP Salinivibrio costicola ? - ? 73514 3.1.3.5 dCMP + H2O - Bos taurus deoxycytidine + phosphate - ? 364579 3.1.3.5 dCMP + H2O 10% of the activity with 5'-AMP Homo sapiens deoxycytidine + phosphate - ? 364579 3.1.3.5 dGMP + H2O 75% of the activity with 5'-AMP Homo sapiens deoxyguanosine + phosphate - ? 64673 3.1.3.5 dIMP + H2O 103% of the activity with 5'-IMP Oncorhynchus masou deoxyinosine + phosphate - ? 364580 3.1.3.5 dIMP + H2O 84% of the activity with 5'-AMP Homo sapiens deoxyinosine + phosphate - ? 364580 3.1.3.5 diphosphate + H2O 5.8% activity compared to 5'-AMP Trichomonas gallinae 2 phosphate - ? 73540 3.1.3.5 diphosphate + H2O 5.8% activity compared to 5'-AMP Trichomonas gallinae TG7 2 phosphate - ? 73540 3.1.3.5 dTMP + H2O 7.5% of the activity with 5'-IMP Oncorhynchus masou thymidine + phosphate - ? 64664 3.1.3.5 dUMP + H2O 7% of the activity with 5'-AMP Homo sapiens deoxyuridine + phosphate - ? 64672 3.1.3.5 FAD + H2O microsomal enzyme Homo sapiens ? - ? 73817 3.1.3.5 GDP + H2O 135% of the activity with ATP Salinivibrio costicola ? - ? 73835 3.1.3.5 GMP + H2O - Saccharomyces cerevisiae guanosine + phosphate - ? 73518 3.1.3.5 GTP + H2O 100% of the activity with ATP Salinivibrio costicola ? - ? 64639 3.1.3.5 IMP + H2O - Homo sapiens inosine + phosphate - ? 434670 3.1.3.5 inosine + 5'-IMP - Homo sapiens 5'-IMP + inosine - ? 382062 3.1.3.5 inosine + phosphate - Bos taurus 5'-IMP + H2O - r 382063 3.1.3.5 inosine + phosphate - Homo sapiens 5'-IMP + H2O - r 382063 3.1.3.5 ITP + H2O 108% of the activity with ATP Salinivibrio costicola ? - ? 64646 3.1.3.5 ITP + H2O very low activity Bacillus subtilis IDP + phosphate - ? 93271 3.1.3.5 methylthio-IMP + H2O - Homo sapiens ? + phosphate - ? 382310 3.1.3.5 additional information no activity with ATP Streptococcus pyogenes ? - ? 89 3.1.3.5 additional information 5'-nucleotidase and phosphodiesterase reside in the same molecule Lutzomyia longipalpis ? - ? 89 3.1.3.5 additional information alcohols do not function as phosphate acceptors and suggests that the enzyme lacks transphosphorylation activity Helicobacter pylori ? - ? 89 3.1.3.5 additional information bifunctional enzyme with UDP-sugar hydrolase and 5'-nucleotidase activities Escherichia coli ? - ? 89 3.1.3.5 additional information no dephosphorylation of araCMP and 2-fluoroadenine-9-beta-D-arabinofuranoside Homo sapiens ? - ? 89 3.1.3.5 additional information significant differences in substrate specificity between the isoforms are interpreted in terms of variable glycosylation causing steric hindrance of the substrate-binding site Bos taurus ? - ? 89 3.1.3.5 additional information the enzyme acts through the formation of a phosphoenzyme intermediate, essential role of Asp52 in the catalytic machinery, Asp54 assists in the formation of the acyl phosphate species Bos taurus ? - ? 89 3.1.3.5 additional information accumulation of Arg, N-acetylarginine, homoarginine and argininic acid do not alter 5'-nucleotidase activity Rattus norvegicus ? - ? 89 3.1.3.5 additional information cN-I may play an important role in the regulation of physiological pyrimidine nucleotide pools and may also alter the therapeutic efficiacy of certain nucleoside analogs Homo sapiens ? - ? 89 3.1.3.5 additional information major role in regulation of adenosine concentrations on airway surfaces Homo sapiens ? - ? 89 3.1.3.5 additional information patients with nucleotidase-associated pervasive developmental disorder exhibit altered electrophoretic mobility of cytosolic 5'-nucleotidase Homo sapiens ? - ? 89 3.1.3.5 additional information the enzyme contributes to function of endothelial cells by inhibiting platelet aggregation in cooperation with ATP diphosphohydrolase, which degrades ADP to AMP Homo sapiens ? - ? 89 3.1.3.5 additional information the enzyme plays a role on purine salvage pathways Rhipicephalus microplus ? - ? 89 3.1.3.5 additional information the soluble forms of enzyme in seminal plasma have a putative role in signalling interactions with spermatozoa following ejaculation and capacitations in the female reproductive tract Bos taurus ? - ? 89 3.1.3.5 additional information high enzyme activity in liver is a feature of constitutive uricotelism, enzyme may participate in the production of uric acid Varanus gouldii ? - ? 89 3.1.3.5 additional information involved in the synthesis of guanine nucleotides from xanthosine Rattus norvegicus ? - ? 89 3.1.3.5 additional information IMP and GMP are the best phosphate donors for phosphotransferase activity, followed by UMP and CMP Rattus norvegicus ? - ? 89 3.1.3.5 additional information no substrate: 3'-IMP, 1-glycerophosphate Crocodylus siamensis ? - ? 89 3.1.3.5 additional information no substrate: 3'-IMP, 1-glycerophosphate Salvator rufescens ? - ? 89 3.1.3.5 additional information 5'-nucleotidase catalyzes the hydrolysis of the phosphoric ester bond of nucleoside 5'-monophosphates, such as AMP, CMP, UMP, IMP and GMP, to the corresponding nucleosides and phosphate Giardia intestinalis ? - ? 89 3.1.3.5 additional information cytosolic 5'-nucleotidase II catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates Homo sapiens ? - ? 89 3.1.3.5 additional information Sdt1 is highly specific for 5'-UMP and 5'-CMP, and shows negligible activity on purine nucleoside monophosphates, 3'-monophosphates or nucleoside triphosphates Saccharomyces cerevisiae ? - ? 89 3.1.3.5 additional information Usha, Pho5, Sdt1 and Phm8 are phosphate starvation-induced 5'-nucleotidases with diverse substrate specificities that liberate phosphate under phosphate starvation conditions Homo sapiens ? - ? 89 3.1.3.5 additional information structural basis for the substrate specificity of cN-II: Arg202, Asp206, and Phe157 seem to be important residues for purine/pyrimidine selectivity Homo sapiens ? - ? 89 3.1.3.5 additional information activity on AMP, XMP, CMP, UMP and -nitrophenyl phosphate is poor Legionella pneumophila ? - ? 89 3.1.3.5 additional information poor substrate: beta-nicotinamide mononucleotide Homo sapiens ? - ? 89 3.1.3.5 additional information no activity with 3'-AMP, 3',5'-cAMP, and 3',5'-cGMP Macrovipera lebetina ? - ? 89 3.1.3.5 additional information no activity with 3'-CMP, 3'-AMP, and UDP-D-glucose Bacillus subtilis ? - ? 89 3.1.3.5 additional information no activity with 3'-CMP, 3'-AMP, and UDP-D-glucose Bacillus subtilis 168 ? - ? 89 3.1.3.5 additional information no activity with ATP Streptococcus pyogenes ATCC 700294 ? - ? 89 3.1.3.5 additional information activity on AMP, XMP, CMP, UMP and -nitrophenyl phosphate is poor Legionella pneumophila DSM 7513 ? - ? 89 3.1.3.5 p-nitrophenyl phenylphosphonate + H2O - Rhipicephalus microplus ? - ? 73816 3.1.3.5 p-nitrophenyl phosphate + H2O - Homo sapiens p-nitrophenol + phosphate - ? 64623 3.1.3.5 p-nitrophenyl phosphate + H2O - Rattus norvegicus p-nitrophenol + phosphate - ? 64623 3.1.3.5 p-nitrophenyl phosphate + H2O - Escherichia coli p-nitrophenol + phosphate - ? 64623 3.1.3.5 p-nitrophenyl phosphate + H2O - Pseudomonas aeruginosa p-nitrophenol + phosphate - ? 64623 3.1.3.5 p-nitrophenyl phosphate + H2O - Saccharomyces cerevisiae p-nitrophenol + phosphate - ? 64623 3.1.3.5 p-nitrophenylphosphate + H2O plasma membrane enzyme: 1% of the activity with 5'-AMP, Golgi apparatus enzyme: 39% of the activity with 5'-AMP Arachis hypogaea p-nitrophenol + phosphate - ? 64433 3.1.3.5 ribavirin + 5'-IMP better substrate than viramidine Homo sapiens ? - ? 382745 3.1.3.5 thio-GMP + H2o - Homo sapiens 6-thioguanosine + phosphate - ? 382879 3.1.3.5 thio-IMP + H2O - Homo sapiens 6-thioinosine + phosphate - ? 382880 3.1.3.5 TTP + H2O 133% of the activity with ATP Salinivibrio costicola ? - ? 64644 3.1.3.5 UDP + H2O 150% of the activity with ATP Salinivibrio costicola ? - ? 73527 3.1.3.5 UMP + H2O - Saccharomyces cerevisiae uridine + phosphate - ? 73528 3.1.3.5 UTP + H2O 53% of the activity with ATP Salinivibrio costicola ? - ? 73532 3.1.3.5 UTP + H2O very low activity Bacillus subtilis UDP + phosphate - ? 73742 3.1.3.5 viramidine + 5'-IMP worse substrate than ribavirin Homo sapiens ? - ? 382967 3.1.3.5 XMP + H2O - Saccharomyces cerevisiae xanthosine + phosphate - ? 383410