3.1.3.4 1,2-diacyl-sn-glycerol 3-phosphate + H2O - Bos taurus 1,2-diacyl-sn-glycerol + phosphate - ? 399321 3.1.3.4 1,2-diacyl-sn-glycerol-3-phosphate + H2O - Momordica charantia 1,2-diacyl-sn-glycerol + phosphate - ? 429571 3.1.3.4 1,2-diacylglycerol 3-phosphate + H2O - Drosophila melanogaster 1,2-diacyl-sn-glycerol + phosphate - ? 446013 3.1.3.4 1,2-diacylglycerol 3-phosphate + H2O - Homo sapiens 1,2-diacyl-sn-glycerol + phosphate - ? 446013 3.1.3.4 1,2-diacylglycerol 3-phosphate + H2O - Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ? 446013 3.1.3.4 1,2-diacylglycerol 3-phosphate + H2O - Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ir 446013 3.1.3.4 1,2-diacylglycerol 3-phosphate + H2O - Candida albicans 1,2-diacyl-sn-glycerol + phosphate - ? 446013 3.1.3.4 1,2-diacylglycerol 3-phosphate + H2O - Saccharomyces cerevisiae W303-1A 1,2-diacyl-sn-glycerol + phosphate - ? 446013 3.1.3.4 1,2-dioleoyl-sn-glycerol 3-phosphate + H2O - Rattus norvegicus 1,2-dioleoyl-sn-glycerol + phosphate - ? 93408 3.1.3.4 1,2-dioleoyl-sn-glycerol-3 phosphate - Mus musculus 1,2-dioleoyl-sn-glycerol + phosphate - ? 390282 3.1.3.4 1,2-dioleoyl-sn-glycerol-3 phosphate insulin and epinephrine control lipin 1 primarily by changing localization rather than intrinsic PAP activity, overview Mus musculus 1,2-dioleoyl-sn-glycerol + phosphate - ? 390282 3.1.3.4 1,2-dipalmitoyl-sn-glycerol 3-phosphate + H2O - Rattus norvegicus 1,2-dipalmitoyl-sn-glycerol + phosphate - ? 93407 3.1.3.4 1-acyl-sn-glycerol 3-phosphate + H2O less than 15% of the activity with phosphatidic acid Saccharomyces cerevisiae 1-acyl-sn-glycerol + phosphate - ? 93406 3.1.3.4 1-acyl-sn-glycerol 3-phosphate + H2O at 9.1% of the activity with phosphatidic acid Rattus norvegicus 1-acyl-sn-glycerol + phosphate - ? 93406 3.1.3.4 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate + H2O - Rattus norvegicus 1-stearoyl-2-arachidonoyl-sn-glycerol + phosphate - ? 93424 3.1.3.4 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycero-3-phosphate + H2O fluorescent substrate deirvative Homo sapiens 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycerol + phosphate - ? 390603 3.1.3.4 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycero-3-phosphate + H2O fluorescent substrate deirvative Rattus norvegicus 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycerol + phosphate - ? 390603 3.1.3.4 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycero-3-phosphate + H2O fluorescent substrate derivative Rattus norvegicus 2-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-pentanoyl)-1-hexadecanoyl-sn-glycerol + phosphate - ? 390603 3.1.3.4 5'-AMP + H2O 8.6% of the activity with phosphatidic acid Rattus norvegicus ? - ? 93414 3.1.3.4 a 3-sn-phosphatidate + H2O - Mus musculus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O - Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O - Rattus norvegicus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O - Saccharomyces cerevisiae a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O - Vigna unguiculata a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O - Parageobacillus toebii a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O dephosphorylation of these lipids terminates their signaling actions and generates products with additional biological activities or metabolic fates, overview Bos taurus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview Mus musculus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Lipin-1 influences lipid homeostasis and plays a critical role in adipocyte development with lipin-1A and lipin-1B having distinct purposes in the process, overview. Phosphorylation plays an important role in modulation of enzyme activity, overview Rattus norvegicus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O key enzyme in glycerolipid synthesis, diacylglycerol is direct precursor of triacylglycerol, phosphoatidylcholine, and phosphatidylethanolamine. Pah1p regulates nuclear membrane growth during cell cycle. Phosphorylation plays an important role in modulation of enzyme activity, overview Saccharomyces cerevisiae a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O key enzyme in the regulation of lipid synthesis, it PAP generates a pool of diacylglycerol used for protein kinase C activation, and attenuates the signaling functions of phosphatidic acid Mus musculus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O key enzyme in the regulation of lipid synthesis, it PAP generates a pool of diacylglycerol used for protein kinase C activation, and attenuates the signaling functions of phosphatidic acid Saccharomyces cerevisiae a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O key enzyme in the regulation of lipid synthesis, PAP generates a pool of diacylglycerol used for protein kinase C activation, and attenuates the signaling functions of phosphatidic acid Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O lipin 1 is a bifunctional intracellular protein that regulates fatty acid metabolism in the nucleus via interactions with DNA-bound transcription factors and at the endoplasmic reticulum as a phosphatidic acid phosphohydrolase enzyme to catalyze the penultimate step in triglyceride synthesis. Lipin 2 plays an important role as a hepatic PAP-1 enzyme Mus musculus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O lipin-1 is negatively regulated by phosphorylation during mitosis Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O lipin-1 plays a critical role in the perturbation of hepatic insulin signaling Mus musculus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O lipin-2 is negatively regulated by phosphorylation during mitosis Mus musculus a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O phosphatidate phosphatases are key enzymes in lipid biosynthesis and signaling. Type I PAP enzymes participate in de-novo phospholipid biosynthesis, whereas type II PAP enzymes have an established role in lipid signaling. The eukaryotic, endoplasmic reticulum-resident PA-PSP is a bifunctional enzyme with specific type II PAP activity, and regulates, in addition to type I PAPs, the de-novo biosynthesis of phospholipids and triacylglycerols Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O the enzyme is involved in lipid synthesis and cell signalling Vigna unguiculata a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O the presqualene diphosphate phosphatase is a potent Mg2+-independent, NEM-insensitive type II PAP Homo sapiens a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 a 3-sn-phosphatidate + H2O - Parageobacillus toebii T-85 a 1,2-diacyl-sn-glycerol + phosphate - ? 398705 3.1.3.4 ATP + H2O 7.2% of the activity with phosphatidic acid Rattus norvegicus ? - ? 64622 3.1.3.4 beta-glycerophosphate + H2O about 10% of the activity with phosphatidic acid Rattus norvegicus glycerol + phosphate - ? 64615 3.1.3.4 ceramide 1-phosphate + H2O - Drosophila melanogaster ceramide + phosphate - ? 381641 3.1.3.4 ceramide 1-phosphate + H2O - Mus musculus ceramide + phosphate - ? 381641 3.1.3.4 ceramide 1-phosphate + H2O - Homo sapiens ceramide + phosphate - ? 381641 3.1.3.4 ceramide 1-phosphate + H2O - Rattus norvegicus ceramide + phosphate - ? 381641 3.1.3.4 ceramide 1-phosphate + H2O - Canis lupus familiaris ceramide + phosphate - ? 381641 3.1.3.4 ceramide 1-phosphate + H2O LPP1 but not LPR1 Homo sapiens ceramide + phosphate - ? 381641 3.1.3.4 ceramide-1-phosphate + H2O isoenzyme PAP-2a and PAP-2b Homo sapiens ? - ? 93416 3.1.3.4 ceramide-1-phosphate + H2O - Eimeria tenella ceramide + phosphate - ? 447290 3.1.3.4 diacylglycerol diphosphate + H2O - Saccharomyces cerevisiae ? - ? 364570 3.1.3.4 diacylglycerol diphosphate + H2O preferred substrate of isozyme DPPL1 Homo sapiens ? - ? 364570 3.1.3.4 diacylglycerol diphosphate + H2O preferred substrate of isozyme DPPL2 Homo sapiens ? - ? 364570 3.1.3.4 diacylglycerol diphosphate + H2O - Saccharomyces cerevisiae phosphatidate + phosphate - ? 390202 3.1.3.4 diacylglycerol diphosphate + H2O - Arabidopsis thaliana phosphatidate + phosphate - ? 390202 3.1.3.4 diacylglycerol diphosphate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol, zinc-mediated regulation, overview Saccharomyces cerevisiae phosphatidate + phosphate - ? 390202 3.1.3.4 diacylglycerol diphosphate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol Saccharomyces cerevisiae phosphatidate + phosphate - ? 390202 3.1.3.4 diacylglycerol diphosphate + H2O the bifunctional LPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it removes the phosphate from phosphatidate to form diacylglycerol Saccharomyces cerevisiae phosphatidate + phosphate - ? 390202 3.1.3.4 diacylglycerol diphosphate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol, zinc-mediated regulation, overview Saccharomyces cerevisiae W303-1A phosphatidate + phosphate - ? 390202 3.1.3.4 diacylglycerol diphosphate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol Saccharomyces cerevisiae W303-1A phosphatidate + phosphate - ? 390202 3.1.3.4 diacylglycerol diphosphate + H2O preferred substrate Parageobacillus toebii ? + phosphate - ? 400835 3.1.3.4 diacylglycerol diphosphate + H2O preferred substrate Parageobacillus toebii T-85 ? + phosphate - ? 400835 3.1.3.4 dicaproyl phosphatidate + H2O best substrate of the 104-kDa enzyme form Saccharomyces cerevisiae 1,2-dicaproyl-sn-glycerol + phosphate - ? 391827 3.1.3.4 didecanoyl phosphatidic acid + H2O - Homo sapiens 1,2-didecanoyl-sn-glycerol + phosphate - ? 93420 3.1.3.4 didecanoyl phosphatidic acid + H2O - Rattus norvegicus 1,2-didecanoyl-sn-glycerol + phosphate - ? 93420 3.1.3.4 dihexanoyl phosphatidic acid + H2O - Homo sapiens 1,2-dihexanoyl-sn-glycerol + phosphate - ? 93418 3.1.3.4 dihexanoyl phosphatidic acid + H2O - Rattus norvegicus 1,2-dihexanoyl-sn-glycerol + phosphate - ? 93418 3.1.3.4 dihydro-sphingosine-1-phosphate + H2O all LPPs Mus musculus dihydro-sphingosine + phosphate - ? 391833 3.1.3.4 dihydro-sphingosine-1-phosphate + H2O all LPPs Homo sapiens dihydro-sphingosine + phosphate - ? 391833 3.1.3.4 dimyristoyl phosphatidic acid + H2O - Homo sapiens 1,2-dimyristoyl-sn-glycerol + phosphate - ? 93421 3.1.3.4 dimyristoyl phosphatidic acid + H2O - Rattus norvegicus 1,2-dimyristoyl-sn-glycerol + phosphate - ? 93421 3.1.3.4 dioctanoyl phosphatidic acid + H2O - Homo sapiens 1,2-dioctanoyl-sn-glycerol + phosphate - ? 93419 3.1.3.4 dioctanoyl phosphatidic acid + H2O PAP1 activity is linear with respect to the substrate at concentrations between 0.05-0.8 mM Saccharomyces cerevisiae 1,2-dioctanoyl-sn-glycerol + phosphate - ? 93419 3.1.3.4 dioleoyl phosphatidate + H2O - Saccharomyces cerevisiae 1,2-dioleoyl-sn-glycerol + phosphate - ? 391842 3.1.3.4 dioleoyl phosphatidic acid + H2O - Homo sapiens 1,2-dioleoyl-sn-glycerol + phosphate - ? 93423 3.1.3.4 dioleoyl phosphatidic acid + H2O - Rattus norvegicus 1,2-dioleoyl-sn-glycerol + phosphate - ? 93423 3.1.3.4 dipalmitoyl phosphatidate + H2O - Saccharomyces cerevisiae 1,2-dipalmitoyl-sn-glycerol + phosphate - ? 391843 3.1.3.4 dipalmitoyl phosphatidic acid + H2O - Homo sapiens ? - ? 93425 3.1.3.4 distearoyl phosphatidic acid + H2O - Rattus norvegicus 1,2-distearoyl-sn-glycerol + phosphate - ? 93422 3.1.3.4 DL-alpha-glycerophosphate + H2O about 10% of the activity with phosphatidic acid Rattus norvegicus glycerol + phosphate - ? 93410 3.1.3.4 FTY720-phosphate + H2O LPP3 Mus musculus FTY720 + phosphate - ? 391999 3.1.3.4 FTY720-phosphate + H2O LPP3 Homo sapiens FTY720 + phosphate - ? 391999 3.1.3.4 Glucose 6-phosphate + H2O at 5.2% of the activity with phosphatidic acid Rattus norvegicus Glucose + phosphate - ? 13176 3.1.3.4 Glucose 6-phosphate + H2O about 10% of the activity with phosphatidic acid Rattus norvegicus Glucose + phosphate - ? 13176 3.1.3.4 glycerophosphate + H2O - Mus musculus glycerol + phosphate - ? 73556 3.1.3.4 lyso-phosphatidate + H2O - Saccharomyces cerevisiae monoacylglycerol + phosphate - ? 447708 3.1.3.4 lyso-phosphatidic acid + H2O - Mus musculus monoacylglycerol + phosphate - ? 392510 3.1.3.4 lyso-phosphatidic acid + H2O - Homo sapiens monoacylglycerol + phosphate - ? 392510 3.1.3.4 lyso-phosphatidic acid + H2O - Rattus norvegicus monoacylglycerol + phosphate - ? 392510 3.1.3.4 lyso-phosphatidic acid + H2O all LPPs Mus musculus monoacylglycerol + phosphate - ? 392510 3.1.3.4 lyso-phosphatidic acid + H2O all LPPs Homo sapiens monoacylglycerol + phosphate - ? 392510 3.1.3.4 lyso-phosphatidic acid + H2O LPP1 but not LPR1 Homo sapiens monoacylglycerol + phosphate - ? 392510 3.1.3.4 lysophosphatidate + H2O - Homo sapiens ? - ? 93415 3.1.3.4 lysophosphatidate + H2O - Rattus norvegicus ? - ? 93415 3.1.3.4 lysophosphatidate + H2O poor substrate Sus scrofa ? - ? 93415 3.1.3.4 lysophosphatidate + H2O isoenzyme PAP-2a and PAP-2b Homo sapiens ? - ? 93415 3.1.3.4 lysophosphatidate + H2O - Saccharomyces cerevisiae monoacylglycerol + phosphate - ? 364569 3.1.3.4 lysophosphatidate + H2O - Eimeria tenella monoacylglycerol + phosphate - ? 364569 3.1.3.4 lysophosphatidic acid + H2O - Rattus norvegicus ? - ? 364567 3.1.3.4 lysophosphatidic acid + H2O - Saccharomyces cerevisiae ? - ? 364567 3.1.3.4 lysophosphatidic acid + H2O - Homo sapiens ? - ? 364567 3.1.3.4 lysophosphatidic acid + H2O - Drosophila melanogaster monoacylglycerol + phosphate - ? 364571 3.1.3.4 lysophosphatidic acid + H2O - Mus musculus monoacylglycerol + phosphate - ? 364571 3.1.3.4 lysophosphatidic acid + H2O - Homo sapiens monoacylglycerol + phosphate - ? 364571 3.1.3.4 lysophosphatidic acid + H2O - Rattus norvegicus monoacylglycerol + phosphate - ? 364571 3.1.3.4 lysophosphatidic acid + H2O - Saccharomyces cerevisiae monoacylglycerol + phosphate - ? 364571 3.1.3.4 lysophosphatidic acid + H2O - Canis lupus familiaris monoacylglycerol + phosphate - ? 364571 3.1.3.4 lysophosphatidic acid + H2O LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Mus musculus monoacylglycerol + phosphate - ? 364571 3.1.3.4 lysophosphatidic acid + H2O LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Homo sapiens monoacylglycerol + phosphate - ? 364571 3.1.3.4 lysophosphatidic acid + H2O - Bos taurus ? + phosphate - ? 401332 3.1.3.4 lysophosphatidic acid + H2O - Parageobacillus toebii ? + phosphate - ? 401332 3.1.3.4 lysophosphatidic acid + H2O - Parageobacillus toebii T-85 ? + phosphate - ? 401332 3.1.3.4 additional information - Rattus norvegicus ? - ? 89 3.1.3.4 additional information both long and short chain lysophosphatidic acids are hydrolyzed at rates comparable with that observed for short chain phosphatidic acids Homo sapiens ? - ? 89 3.1.3.4 additional information negligible activity towards long-chain phosphatidic acid Homo sapiens ? - ? 89 3.1.3.4 additional information the functional role of the enzyme in lamellar bodies is proposed in relation to glycerophospholipd metabolism Sus scrofa ? - ? 89 3.1.3.4 additional information activation of cytosolic phospholipase A 2 and attendant arachidonic acid release by phorbol esters in WISH cells requires prior generation of diacylglycerol by phosphatidate phosphohydrolase Homo sapiens ? - ? 89 3.1.3.4 additional information the enzyme is involved in de novo synthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine Rattus norvegicus ? - ? 89 3.1.3.4 additional information the enzyme from plasma membrane increases in liver fibrosis but not regeneration. Stimulation of phosphatidate phosphohydrolase with its effect on the diacylglycerol/phosphatidate ratio may play a role in transduction of the fibrosis signal Homo sapiens ? - ? 89 3.1.3.4 additional information the enzyme is proposed to catalyze the first enzymatic step in the important glucolipid pathway Acholeplasma laidlawii ? - ? 89 3.1.3.4 additional information the enzyme plays a major role in the synthesis of phospholipid and triacylglycerol Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information critical roles of the enzyme in cell growth and differentiation Homo sapiens ? - ? 89 3.1.3.4 additional information the 45000 Da enzyme form and 104000 Da enzyme form are induced when cells enter the stationary phase of growth Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information the enzyme may play an important role in regulating inflammatory cell responses to extracellular phosphatidic acid in biological system Homo sapiens ? - ? 89 3.1.3.4 additional information the Mg2+-dependent enzyme of rat lung is involved in pulmonary glycerolipid biosynthesis Rattus norvegicus ? - ? 89 3.1.3.4 additional information the diacylglycerol formed by the enzyme is used as a substrate for galactolipid synthesis on the inner envelope membrane Spinacia oleracea ? - ? 89 3.1.3.4 additional information the activity associated with the cytosol has a role in phosphocholine biosynthesis in rat lung Rattus norvegicus ? - ? 89 3.1.3.4 additional information the enzyme catalyzes the final steps in the reesterification of fatty acids to triacylglycerols Rattus norvegicus ? - ? 89 3.1.3.4 additional information key enzyme involved in glycerolipid synthesis where it converts phosphatidic acid to diacylglycerol. PAP-1 is involved in phospholipid biosynthesis Rattus norvegicus ? - ? 89 3.1.3.4 additional information rate-limiting enzyme for triglyceride synthesis, short-term administration of conjugated linoleic acid reduces activity 20% Rattus norvegicus ? - ? 89 3.1.3.4 additional information role of PAP-1 as a key enzyme for cell integrity and survival Homo sapiens ? - ? 89 3.1.3.4 additional information the enzyme plays an important role in regulating lipid synthesis in Saccharomyces cerevisiae, the enzyme is also involved in cell signaling mechanisms as part of the phospholipase D-phosphatidate phosphatase pathway Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways Homo sapiens ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, LPP-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration via the p42/p44 MAPK pathway, overview Mus musculus ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview Mus musculus ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview Homo sapiens ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview Rattus norvegicus ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview Canis lupus familiaris ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, LPP-3 is involved in embryonal axis patterning, overview Homo sapiens ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview Mus musculus ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview Rattus norvegicus ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview Homo sapiens ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, Wunen and Wunen2 are essential for germ cell development, overview Drosophila melanogaster ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, thus the enzyme is involved in cell division, cytoskeletal rearrangement, Ca2+ transients, and membrane movement, the enzyme is also able to hydrolyze extracellular substrates, lysophosphatidic acid and sphingosine 1-phosphate, involved in wound repair and tumor growth, overview, expression of PRG-1 in neurons increases extracellular lysophosphatidic acid breakdown and attenuates LPA-induced axonal retraction, metabolism of lysophosphatidic acid and sphingosine 1-phosphate, intra- and extracellular function, overview Homo sapiens ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes Mus musculus ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes Homo sapiens ? - ? 89 3.1.3.4 additional information LPP is involved in regulation of bioactive lipids, physiological roles of LPP isozymes Rattus norvegicus ? - ? 89 3.1.3.4 additional information regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools, the enzyme reduces the stimulation of the p42/p44 MAPK signalling pathway by sphingosine 1-phosphate and lysophosphatidic acid Homo sapiens ? - ? 89 3.1.3.4 additional information the enzyme activity is involved in generation of phosphatidic acid and diaclyglycerol implicated in signal transduction, and in aging, overview Rattus norvegicus ? - ? 89 3.1.3.4 additional information the enzyme dephosphorylates bioactive lipid messengers, modifying or attenuating their activities, it plays a pivotal role in primordial germ cell migration and survival during embryogenesis Drosophila melanogaster ? - ? 89 3.1.3.4 additional information the enzyme is involved in phototransduction, the enzyme acts synergistically with the diacylglycerol kinase, encoded by gene rdgA, both regulating response termination during phototransduction, regulation of phototransduction and phosphatidyl inositol 4,5-bisphosphate lipid signaling cascade, overview Drosophila melanogaster ? - ? 89 3.1.3.4 additional information the enzyme regulates the level of phosphorylated lipids acting as growth factors or second messengers, the enzyme is involved in lipid signaling pathways Mus musculus ? - ? 89 3.1.3.4 additional information Wunen and Wunen2 are involved in regulation of bioactive lipids and in survival and migration of germ cells, physiological roles of LPP isozymes Drosophila melanogaster ? - ? 89 3.1.3.4 additional information substrate specificities of isozymes Mus musculus ? - ? 89 3.1.3.4 additional information substrate specificities of isozymes Homo sapiens ? - ? 89 3.1.3.4 additional information substrate specificities of isozymes Rattus norvegicus ? - ? 89 3.1.3.4 additional information the enzyme is homologous to mammalian lipin Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information the enzyme is homologous to murine lipid phosphate phosphatase isozyme LPP-1 Homo sapiens ? - ? 89 3.1.3.4 additional information Wunen does not interact with its counterpart Wunen-2 Drosophila melanogaster ? - ? 89 3.1.3.4 additional information Wunen does not interact with Wunen2 Drosophila melanogaster ? - ? 89 3.1.3.4 additional information expression of phosphatidic acid phosphatase 2a, which hydrolyzes lipids to generate diacylglycerol, is regulated by p73, a member of the p53 family, overview Homo sapiens ? - ? 89 3.1.3.4 additional information increasing LPP2 activity causes premature cyclin A expression and decreased LPP2 expression delays cyclin A expression, overview Homo sapiens ? - ? 89 3.1.3.4 additional information lipin-1 Smp2 exhibits phosphatidate phosphatase type-1 activity, which plays a key role in glycerolipid synthesis Mus musculus ? - ? 89 3.1.3.4 additional information lipin-1 Smp2 exhibits phosphatidate phosphatase type-1 activity, which plays a key role in glycerolipid synthesis Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information mutations in laza causes a reduction in the light response and faster termination kinetics, loss of laza suppressed the severity of the phenotype caused by mutation of the diacylglycerol kinase, RDGA, retinal degeneration resulting from overexpression of the phospholipase D is suppressed by elimination of Laza, the flies have a requirement for a PLD/PAP-dependent pathway for achieving the maximal light response, since the Drosophila phototransduction cascade serves as a paradigm for characterizing the regulation of sensory signaling and TRP channels in vivo Drosophila melanogaster ? - ? 89 3.1.3.4 additional information phosphatidic acid phosphohydrolase, PAP, catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol, the second messenger responsible for activation of protein kinase C Homo sapiens ? - ? 89 3.1.3.4 additional information phosphatidic acid phosphohydrolase, PAP, catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol, the second messenger responsible for activation of protein kinase C Rattus norvegicus ? - ? 89 3.1.3.4 additional information phosphatidic acid phosphohydrolase-1 is required for lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages or P388D1 cells, inhibition of PAP-1 results in a decrease in LPS-induced COX-2 mRNA transcript production, COX-2 protein expression, and prostaglandin E2 release, regulation, overview Homo sapiens ? - ? 89 3.1.3.4 additional information the enzyme is involved in the activation of 5-lipoxygenase in polymorphonuclear leukocytes together with phospholipase D via diacylglyceride generation, PLD/PA-P pathway, overview Homo sapiens ? - ? 89 3.1.3.4 additional information the enzyme is regulated by estrogens in the liver and the uterus, E2 downregulates the enzyme in the uterus via the estrogen receptor in a primary response, overview Mus musculus ? - ? 89 3.1.3.4 additional information the enzyme plays a major role in the synthesis of triacylglycerols and phospholipids in Saccharomyces cerevisiae, the PAH1 gene product is essential for its roles in lipid metabolism and cell physiology, role of PAH1-encoded PAP1 in lipid synthesis, pathway, overview Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information lipin contains the DXDX(T/V) active site motif Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information LPR1 does not hydrolyze phospholipid substrates under conditions that readily support LPP1 activity Homo sapiens ? - ? 89 3.1.3.4 additional information PAH1-encoded Mg2+-dependent PAP1 catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol and phosphate, PAP1 contains the catalytic motif DIDGT at residues 398–402 and a conserved Gly80 residue Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information the enzyme also shows diacylglycerol lipase activity, EC 3.1.1.34, overview Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information the LPP1-encoded enzyme has broad substrate specificity Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information expression of lipin-1 cells stimulates glycerolipid synthesis and secretion in McA-RH7777, overview Rattus norvegicus ? - ? 89 3.1.3.4 additional information hyperactivation of TORC2 exacerbates insulin resistance by enhancing expression of LIPIN1, a mammalian phosphatidic acid phosphatase for diacylglycerol synthesis, overview Mus musculus ? - ? 89 3.1.3.4 additional information lipin 2 is dynamically regulated in liver but is not a target gene of PGC-1alpha Mus musculus ? - ? 89 3.1.3.4 additional information lipin-1 operates as a transcriptional coactivator in the nucleus together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism. Lipin-1 levels are reduced in adipocytes from obesive persons. Lipin-2 mutations are involved in human diseases such as cutaneous inflammation, osteomyelitis and dyserythropoietic anemia, muations of lipin-1 cause recurrent acute myoglobinuria Homo sapiens ? - ? 89 3.1.3.4 additional information lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators to modulate gene expression in lipid metabolism Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism Mus musculus ? - ? 89 3.1.3.4 additional information lipin-1 operates as a transcriptional coactivator together with nuclear receptors and coactivators, e.g. PPARgamma coactivator 1alpha, i.e. PGC-1alpha, to modulate gene expression in lipid metabolism Rattus norvegicus ? - ? 89 3.1.3.4 additional information phosphatidic acid phosphohydrolase 1 and protein kinase C are required for Toll-like receptor-4-mediated group IVA phospholipase A2 activation, regulation, overview Mus musculus ? - ? 89 3.1.3.4 additional information competition between phosphatidic acid, lysophosphatidic acid by the active site of LPPs is modulated by rod outer segment illumination state and by rod outer segment protein association/dissociation, overview Bos taurus ? - ? 89 3.1.3.4 additional information endogenous LPP2 and LPP3 form a complex Mus musculus ? - ? 89 3.1.3.4 additional information PAP1 activity is conferred by the DxDxT motif of the C-Lip domain contained in all lipin family members Saccharomyces cerevisiae ? - ? 89 3.1.3.4 additional information recombinant PAP2L2 shows a broad substrate specificity Parageobacillus toebii ? - ? 89 3.1.3.4 additional information the catalytic site is arranged into three distinct domains: one substrate recognition site and two catalytic sites Homo sapiens ? - ? 89 3.1.3.4 additional information the enzyme is proposed to catalyze the first enzymatic step in the important glucolipid pathway Acholeplasma laidlawii A ? - ? 89 3.1.3.4 additional information recombinant PAP2L2 shows a broad substrate specificity Parageobacillus toebii T-85 ? - ? 89 3.1.3.4 octanoyl lysophosphatidic acid + H2O - Homo sapiens ? - ? 93426 3.1.3.4 oleoyl phosphatidic acid + H2O - Homo sapiens ? - ? 93427 3.1.3.4 p-nitrophenyl phosphate + H2O about 10% of the activity with phosphatidic acid Rattus norvegicus 4-nitrophenol + phosphate - ? 83089 3.1.3.4 phosphatidate + H2O - Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ? 364568 3.1.3.4 phosphatidate + H2O - Yarrowia lipolytica 1,2-diacyl-sn-glycerol + phosphate - ? 364568 3.1.3.4 phosphatidate + H2O biochemical regulation of PA phosphatases involving phospholipids, nucleotides ATP and CTP and the cAMP-dependent protein kinase A, phosphorylation does not affect substrate binding but does alter the catalytic step in the reaction, overview, PA phosphatase activity is regulated by biochemical and genetic mechanisms in a reciprocal manner with the regulation of the phospholipid biosynthetic enzyme phosphatidylserin synthase, overview Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ? 364568 3.1.3.4 phosphatidate + H2O preferred substrate, the bifunctional LPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it removes the phosphate from phosphatidate to form diacylglycerol Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ? 364568 3.1.3.4 phosphatidate + H2O - Yarrowia lipolytica Po1g 1,2-diacyl-sn-glycerol + phosphate - ? 364568 3.1.3.4 phosphatidate + H2O preferred substrate Saccharomyces cerevisiae diacyl-sn-glycerol + phosphate - ? 390281 3.1.3.4 phosphatidate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol, zinc-mediated regulation, overview Saccharomyces cerevisiae diacyl-sn-glycerol + phosphate - ? 390281 3.1.3.4 phosphatidate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol Saccharomyces cerevisiae diacyl-sn-glycerol + phosphate - ? 390281 3.1.3.4 phosphatidate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol, zinc-mediated regulation, overview Saccharomyces cerevisiae W303-1A diacyl-sn-glycerol + phosphate - ? 390281 3.1.3.4 phosphatidate + H2O the bifunctional DPP1 catalyzes the removal of the beta-phosphate from diacylglycerol diphosphate to form phosphatidate, reaction of EC 3.1.3.B2, and it then removes the phosphate from phosphatidate to form diacylglycerol Saccharomyces cerevisiae W303-1A diacyl-sn-glycerol + phosphate - ? 390281 3.1.3.4 phosphatidate + H2O - Eimeria tenella diacylglycerol + phosphate - ? 447982 3.1.3.4 phosphatidic acid + H2O - Mus musculus ? - ? 64437 3.1.3.4 phosphatidic acid + H2O - Vicia faba 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Cavia porcellus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Drosophila melanogaster 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Mus musculus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Escherichia coli 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Homo sapiens 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Sus scrofa 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ir 93405 3.1.3.4 phosphatidic acid + H2O - Bos taurus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Spinacia oleracea 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Arabidopsis thaliana 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Yarrowia lipolytica 1,2-diacyl-sn-glycerol + phosphate - r 93405 3.1.3.4 phosphatidic acid + H2O - Arachis hypogaea 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Mesocricetus auratus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Vigna radiata 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Acholeplasma laidlawii 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Tetrahymena thermophila 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O highly specific for Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O membrane-bound phosphatidic acid and aqueously dispersed phosphatidic acid Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O phosphatidate bound to microsomal membrane, phosphatidate in sonicated dispersion of organic solvent-disrupted microsomes or phosphatidate dispersed in sonicated microsomal lipid Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O phosphatidic acid pure or in mixed micelles with phosphatidylcholine Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O lipin-1, lipin-2, and lipin-3 Mus musculus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O both PAH1 and PAH2 have two domains, the amino-terminal lipin and carboxy-terminal lipin domains. PAH1 and PAH2 may supply diacylglycerol as a substrate of galactolipid synthesis, and phosphatidic acid hydrolyzed by PAH1 and PAH2 may be derived from phosphatidylcholine and phosphatidylethanolamine Arabidopsis thaliana 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Mus musculus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Homo sapiens 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O diacylglycerol is the necessary precursor for the synthesis of triacylglycerols, phosphatidylcholine and phosphatidylethanolamine Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O Pah1p also uses phosphatidic acid to produce phosphatidylethanolamine and phosphatidylcholine through a second parallel route, the cytidine diphosphate diacylglycerol pathway Saccharomyces cerevisiae 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Tetrahymena thermophila CU428 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Yarrowia lipolytica Po1g 1,2-diacyl-sn-glycerol + phosphate - r 93405 3.1.3.4 phosphatidic acid + H2O - Mus musculus C57/BL6J 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Acholeplasma laidlawii A 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Tetrahymena thermophila B2086 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Saccharomyces cerevisiae W303-1A 1,2-diacyl-sn-glycerol + phosphate - ? 93405 3.1.3.4 phosphatidic acid + H2O - Homo sapiens 1,2-diacylglycerol + phosphate - ? 380698 3.1.3.4 phosphatidic acid + H2O - Saccharomyces cerevisiae 1,2-diacylglycerol + phosphate - ? 380698 3.1.3.4 phosphatidic acid + H2O lipid phosphate phosphatase enzymes may play a role in signal transduction by terminating signaling events of lipid phosphates Saccharomyces cerevisiae 1,2-diacylglycerol + phosphate - ? 380698 3.1.3.4 phosphatidic acid + H2O lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation, LPP1 expression decreases PLD activity and PA accumulation after stimulating fibroblasts with either LPA or PDGF, but PLD-dependent PA formation Is only required for LPA-induced fibroblast migration, overview Mus musculus 1,2-diacylglycerol + phosphate - ? 380698 3.1.3.4 phosphatidic acid + H2O PAP activity has a central role in the synthesis of phospholipids and triacylglycerol through its product diacylglycerol, and it also generates and/or degrades lipid-signaling molecules that are related to phosphatidate, isozyme PAP1 plays a role in the transcriptional regulation of phospholipid synthesis, overview Saccharomyces cerevisiae 1,2-diacylglycerol + phosphate - ? 380698 3.1.3.4 phosphatidic acid + H2O the conserved arginine residue in domain 1 and the conserved histidine residues in domains 2 and 3 are essential for catalytic activity Saccharomyces cerevisiae 1,2-diacylglycerol + phosphate - ? 380698 3.1.3.4 phosphatidic acid + H2O - Drosophila melanogaster diacylglycerol + phosphate - ? 380699 3.1.3.4 phosphatidic acid + H2O - Mus musculus diacylglycerol + phosphate - ? 380699 3.1.3.4 phosphatidic acid + H2O - Homo sapiens diacylglycerol + phosphate - ? 380699 3.1.3.4 phosphatidic acid + H2O - Rattus norvegicus diacylglycerol + phosphate - ? 380699 3.1.3.4 phosphatidic acid + H2O - Saccharomyces cerevisiae diacylglycerol + phosphate - ? 380699 3.1.3.4 phosphatidic acid + H2O - Canis lupus familiaris diacylglycerol + phosphate - ? 380699 3.1.3.4 phosphatidic acid + H2O LPP1 but not LPR1 Homo sapiens diacylglycerol + phosphate - ? 380699 3.1.3.4 phosphatidic acid + H2O - Arabidopsis thaliana 1,2-sn-diacylglycerol + phosphate - ? 390283 3.1.3.4 phosphatidic acid + H2O preferred substrate Parageobacillus toebii 1,2-sn-diacylglycerol + phosphate - ? 390283 3.1.3.4 phosphatidic acid + H2O the plastidic phosphatidic acid phosphatase dephosphorylates phosphatidic acid to yield diacylglycerol, which is a precursor for galactolipids, a primary and indispensable component of photosynthetic membranes Arabidopsis thaliana 1,2-sn-diacylglycerol + phosphate - ? 390283 3.1.3.4 phosphatidic acid + H2O preferred substrate Parageobacillus toebii T-85 1,2-sn-diacylglycerol + phosphate - ? 390283 3.1.3.4 phosphatidic acid + H2O - Mus musculus phosphate + diacylglycerol - ? 393222 3.1.3.4 sphingosine 1-phosphate + H2O poor substrate Rattus norvegicus ? - ? 93417 3.1.3.4 sphingosine 1-phosphate + H2O hydrolysis by isoenzyme PAP-2b, no hydrolysis by isoenzyme PAP-2a Homo sapiens ? - ? 93417 3.1.3.4 sphingosine 1-phosphate + H2O - Drosophila melanogaster sphingosine + phosphate - ? 380760 3.1.3.4 sphingosine 1-phosphate + H2O - Mus musculus sphingosine + phosphate - ? 380760 3.1.3.4 sphingosine 1-phosphate + H2O - Homo sapiens sphingosine + phosphate - ? 380760 3.1.3.4 sphingosine 1-phosphate + H2O - Rattus norvegicus sphingosine + phosphate - ? 380760 3.1.3.4 sphingosine 1-phosphate + H2O - Canis lupus familiaris sphingosine + phosphate - ? 380760 3.1.3.4 sphingosine 1-phosphate + H2O all LPPs Mus musculus sphingosine + phosphate - ? 380760 3.1.3.4 sphingosine 1-phosphate + H2O all LPPs Homo sapiens sphingosine + phosphate - ? 380760 3.1.3.4 sphingosine 1-phosphate + H2O LPP1 but not LPR1 Homo sapiens sphingosine + phosphate - ? 380760 3.1.3.4 sphingosine-1-phosphate + H2O - Eimeria tenella sphingosine + phosphate - ? 446353 3.1.3.4 sphingosine-1-phosphate + H2O - Mus musculus sphingosine + phosphate - ? 446353 3.1.3.4 sphingosine-1-phosphate + H2O - Homo sapiens sphingosine + phosphate - ? 446353 3.1.3.4 sphingosine-1-phosphate + H2O LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Mus musculus sphingosine + phosphate - ? 446353 3.1.3.4 sphingosine-1-phosphate + H2O LPP3 regulates intracellular and extracellular lysophosphatidic acid and sphingosine-1-phosphate signalling through the dephosphorylation of these bioactive lipids Homo sapiens sphingosine + phosphate - ? 446353