2.8.3.9	3-hydroxypropanoate + acetoacetyl-CoA	reaction at 8.6% the rate of butyrate	Clostridium sp.	3-hydroxypropanoyl-CoA + acetoacetate	-	r	358839	
2.8.3.9	3-mercaptopropionate + acetoacetyl-CoA	reaction at 71% the rate of butyrate	Clostridium sp.	3-mercaptopropionyl-CoA + acetoacetate	-	r	358826	
2.8.3.9	3-methylvinylacetate + acetoacetyl-CoA	reaction at 44% the rate of butyrate	Clostridium sp.	3-methylvinylacetyl-CoA + acetoacetate	-	r	358832	
2.8.3.9	4-hydroxybutyrate + acetoacetyl-CoA	reaction at 14% the rate of butyrate	Clostridium sp.	4-hydroxybutanoyl-CoA + acetoacetate	-	r	358838	
2.8.3.9	4-pentenoate + acetoacetyl-CoA	reaction at 21% the rate of acetate	Escherichia coli	4-pentenoyl-CoA + acetoacetate	-	r	358849	
2.8.3.9	acetate + acetoacetyl-CoA	-	Bos taurus	acetyl-CoA + acetoacetate	-	r	358821	
2.8.3.9	acetate + acetoacetyl-CoA	-	Clostridium sp.	acetyl-CoA + acetoacetate	-	r	358821	
2.8.3.9	acetate + acetoacetyl-CoA	-	Clostridium tyrobutyricum	acetyl-CoA + acetoacetate	-	r	358821	
2.8.3.9	acetate + acetoacetyl-CoA	best substrates	Escherichia coli	acetyl-CoA + acetoacetate	-	r	358821	
2.8.3.9	acetate + acetoacetyl-CoA	reaction at 24% the rate of butyrate	Clostridium sp.	acetyl-CoA + acetoacetate	-	r	358821	
2.8.3.9	acetate + acetoacetyl-CoA	-	Clostridium sp. SB4	acetyl-CoA + acetoacetate	-	r	358821	
2.8.3.9	acetate + acetoacetyl-CoA	reaction at 24% the rate of butyrate	Clostridium sp. SB4	acetyl-CoA + acetoacetate	-	r	358821	
2.8.3.9	acetate + acetoacetyl-CoA	best substrates	Escherichia coli C22	acetyl-CoA + acetoacetate	-	r	358821	
2.8.3.9	acetyl-CoA + acetoacetate	best substrates	Escherichia coli	acetate + acetoacetyl-CoA	-	r	358822	
2.8.3.9	acetyl-CoA + acetoacetate	best substrates	Escherichia coli C22	acetate + acetoacetyl-CoA	-	r	358822	
2.8.3.9	acrylate + acetoacetyl-CoA	reaction at 10% the rate of butyrate	Clostridium sp.	acrylyl-CoA + acetoacetate	-	r	358836	
2.8.3.9	butanoate + acetoacetyl-CoA	-	Escherichia coli	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	-	Bos taurus	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	-	Acetoanaerobium sticklandii	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	-	Clostridium sp.	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	-	Clostridium tyrobutyricum	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	reaction at 68% the rate of acetate	Escherichia coli	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	lysine degradation pathway	Clostridium sp.	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	-	Clostridium sp. SB4	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	lysine degradation pathway	Clostridium sp. SB4	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	-	Escherichia coli C22	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoate + acetoacetyl-CoA	reaction at 68% the rate of acetate	Escherichia coli C22	butanoyl-CoA + acetoacetate	-	r	358820	
2.8.3.9	butanoyl-CoA + 2-methylacetoacetate	used 12% as fast as acetoacetate	Clostridium sp.	butanoate + 2-methylacetoacetyl-CoA	-	r	358846	
2.8.3.9	butanoyl-CoA + 3-oxohexanoate	used 21% as fast as acetoacetate	Clostridium sp.	butanoate + 3-oxohexanoyl-CoA	-	r	358845	
2.8.3.9	butanoyl-CoA + 3-oxopentanoate	used 60% as fast as acetoacetate	Clostridium sp.	butanoate + 3-oxopentanoyl-CoA	-	r	358844	
2.8.3.9	butanoyl-CoA + acetoacetate	-	Clostridium sp.	butanoate + acetoacetyl-CoA	-	r	358843	
2.8.3.9	butyrate + acetyl-CoA	reaction at 56% the rate of acetoacetate, reverse reaction at 86% the rate of acetoacetyl-CoA	Escherichia coli	butyryl-CoA + acetate	-	r	358842	
2.8.3.9	crotonate + acetoacetyl-CoA	reaction at 16% the rate of butyrate	Clostridium sp.	crotonyl-CoA + acetoacetate	-	r	358827	
2.8.3.9	crotonyl-CoA + acetate	reaction at 4% the rate of acetoacetylCoA	Escherichia coli	crotonate + acetyl-CoA	-	r	358828	
2.8.3.9	DL-2-hydroxybutyrate + acetoacetyl-CoA	reaction at 19% the rate of butyrate	Clostridium sp.	2-hydroxybutyryl-CoA + acetoacetate	-	r	358841	
2.8.3.9	DL-2-hydroxypentanoate + acetoacetyl-CoA	reaction at 7.9% the rate of butyrate	Clostridium sp.	2-hydroxypentanoyl-CoA + acetoacetate	-	r	358834	
2.8.3.9	DL-3-hydroxybutyrate + acetoacetyl-CoA	reaction at 30% the rate of butyrate	Clostridium sp.	3-hydroxybutyryl-CoA + acetoacetate	-	r	358833	
2.8.3.9	DL-3-hydroxybutyrate + acetyl-CoA	reaction at 9% the rate of acetoacetate	Escherichia coli	3-hydroxybutyryl-CoA + acetate	-	r	358840	
2.8.3.9	epsilon-acetyl-CoA + acetoacetate	reaction at 1% the rate of acetylCoA	Escherichia coli	acetate + acetoacetyl-CoA	-	r	358823	
2.8.3.9	formate + acetoacetyl-CoA	reaction at 7% the rate of acetate	Escherichia coli	formyl-CoA + acetoacetate	-	r	358847	
2.8.3.9	isobutyrate + acetoacetyl-CoA	reaction at 19% the rate of butyrate	Clostridium sp.	isobutyryl-CoA + acetoacetate	-	r	358830	
2.8.3.9	isopentanoate + acetoacetyl-CoA	reaction at 8.3% the rate of butyrate	Clostridium sp.	isopentanoyl-CoA + acetoacetate	-	r	358835	
2.8.3.9	monochloroacetate + acetoacetyl-CoA	reaction at 5.4% the rate of butyrate	Clostridium sp.	monochloroacetyl-CoA + acetoacetate	-	r	358837	
2.8.3.9	additional information	decanoyl-CoA and succinyl-CoA cannot replace acetoacetyl-CoA, succinate, malonate and 2,3-butandienoate cannot replace acetate, 3-carbon dicarboxylic and 4-carbon dicarboxylic acids are completely inactive as substrates	Escherichia coli	?	-	?	89	
2.8.3.9	additional information	monofluoroacetate and hexanoate are no substrates, compounds found to be unreactive or less than 0.1% as reactive as butyrate are formate, cyanoacetate, n-heptanoate, tiglate, oxalate, malonate, succinate, citramalate, DL-alpha-hydroxyisobutyrate, 3,4-dihydroxybutyrate, alpha-ketobutyrate, 2-oxoglutarate, DL-3-aminobutyrate and 4-aminobutyrate, 3-oxo-5-aminohexanoate and triacetate are unreactive	Clostridium sp.	?	-	?	89	
2.8.3.9	additional information	monofluoroacetate and hexanoate are no substrates, compounds found to be unreactive or less than 0.1% as reactive as butyrate are formate, cyanoacetate, n-heptanoate, tiglate, oxalate, malonate, succinate, citramalate, DL-alpha-hydroxyisobutyrate, 3,4-dihydroxybutyrate, alpha-ketobutyrate, 2-oxoglutarate, DL-3-aminobutyrate and 4-aminobutyrate, 3-oxo-5-aminohexanoate and triacetate are unreactive	Clostridium sp. SB4	?	-	?	89	
2.8.3.9	additional information	decanoyl-CoA and succinyl-CoA cannot replace acetoacetyl-CoA, succinate, malonate and 2,3-butandienoate cannot replace acetate, 3-carbon dicarboxylic and 4-carbon dicarboxylic acids are completely inactive as substrates	Escherichia coli C22	?	-	?	89	
2.8.3.9	octanoate + acetoacetyl-CoA	reaction at 3% the rate of acetate	Escherichia coli	octanoyl-CoA + acetoacetate	-	r	358848	
2.8.3.9	pentanoate + acetoacetyl-CoA	reaction at 19% the rate of butyrate	Clostridium sp.	pentanoyl-CoA + acetoacetate	-	r	358829	
2.8.3.9	propionate + acetoacetyl-CoA	-	Bos taurus	propionyl-CoA + acetoacetate	-	r	358825	
2.8.3.9	propionate + acetoacetyl-CoA	reaction at 21% the rate of butyrate	Clostridium sp.	propionyl-CoA + acetoacetate	-	r	358825	
2.8.3.9	vinylacetate + acetoacetyl-CoA	best substrate	Clostridium sp.	vinylacetyl-CoA + acetoacetate	-	r	358824