2.7.7.24 ATP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium ADP-glucose + diphosphate - ? 387956 2.7.7.24 ATP + alpha-D-glucose 1-phosphate 1% activity compared to dTTP Streptomyces sp. ADP-glucose + diphosphate - r 387956 2.7.7.24 ATP + alpha-D-glucose 1-phosphate 1% activity compared to dTTP Streptomyces sp. SCC-2136 ADP-glucose + diphosphate - r 387956 2.7.7.24 ATP + alpha-D-glucose 1-phosphate - Pyrococcus horikoshii diphosphate + ADP-alpha-D-glucose - ? 444926 2.7.7.24 ATP + alpha-D-glucose 1-phosphate RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP Caenorhabditis elegans diphosphate + ADP-alpha-D-glucose - ? 444926 2.7.7.24 ATP + alpha-D-glucose 1-phosphate 13% yield with 0.006 mM enzyme, 78% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + ADP-alpha-D-glucose - ? 444926 2.7.7.24 ATP + alpha-D-glucose-1-phosphate 1.0% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. ADP-glucose + diphosphate - ? 387957 2.7.7.24 ATP + alpha-D-glucose-1-phosphate 1.0% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. SCC-2136 ADP-glucose + diphosphate - ? 387957 2.7.7.24 CTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium CDP-glucose + diphosphate - ? 388405 2.7.7.24 CTP + alpha-D-glucose 1-phosphate 1.2% activity compared to dTTP Streptomyces sp. CDP-glucose + diphosphate - r 388405 2.7.7.24 CTP + alpha-D-glucose 1-phosphate - Pyrococcus horikoshii diphosphate + CDP-alpha-D-glucose - ? 445319 2.7.7.24 CTP + alpha-D-glucose 1-phosphate RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP Caenorhabditis elegans diphosphate + CDP-alpha-D-glucose - ? 445319 2.7.7.24 CTP + alpha-D-glucose-1-phosphate 1.2% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. CDP-glucose + diphosphate - ? 388406 2.7.7.24 CTP + alpha-D-glucose-1-phosphate 1.2% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. SCC-2136 CDP-glucose + diphosphate - ? 388406 2.7.7.24 D-glucosamine 1-phosphate + TTP - Niallia circulans TTP-D-glucosamine + diphosphate - ? 420535 2.7.7.24 D-glucosamine 1-phosphate + UTP - Niallia circulans UDP-D-glucosamine + diphosphate - ? 420536 2.7.7.24 D-glucose 1-phosphate + UTP - Niallia circulans UDP-D-glucose + diphosphate - ? 420542 2.7.7.24 dATP + alpha-D-glucosamine 1-phosphate 21% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dADP-alpha-D-glucosamine - ? 459598 2.7.7.24 dATP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium dADP-glucose + diphosphate - ? 379684 2.7.7.24 dATP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium LT2 dADP-glucose + diphosphate - ? 379684 2.7.7.24 dCTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium dCDP-glucose + diphosphate - ? 379688 2.7.7.24 dCTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium LT2 dCDP-glucose + diphosphate - ? 379688 2.7.7.24 dCTP + alpha-D-glucose 1-phosphate 35% yield with 0.006 mM enzyme, 87% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dCDP-alpha-D-glucose - ? 426271 2.7.7.24 deoxythymidine 5'-tetraphosphate + alpha-D-glucose 1-phosphate - Streptococcus pneumoniae triphosphate + dTDP-alpha-D-glucose alternative products dTTP-alpha-D-glucose and diphosphate are not detected ? 437383 2.7.7.24 dGTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium dGDP-glucose + diphosphate - ? 379696 2.7.7.24 dGTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium LT2 dGDP-glucose + diphosphate - ? 379696 2.7.7.24 dGTP + alpha-D-glucose 1-phosphate 53% yield with 0.006 mM enzyme, 89% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dGDP-alpha-D-glucose - ? 426291 2.7.7.24 diphosphate + dTDP-alpha-D-glucose - Sulfurisphaera tokodaii dTTP + alpha-D-glucose 1-phosphate - r 445457 2.7.7.24 dTDP-glucose + diphosphate - Sphingomonas elodea dTTP + alpha-D-glucose 1-phosphate - ? 378670 2.7.7.24 dTDP-glucose + diphosphate protein by ugpG gene is involved in gellan gum biosynthesis and exhibits both dTDP- and UDP-glucose diphosphorylase activities Sphingomonas elodea dTTP + alpha-D-glucose 1-phosphate - ? 378670 2.7.7.24 dTDP-glucose + diphosphate protein encoded by rmlA gene is involved in gellan gum biosynthesis and exhibits both dTDP- and UDP-glucose diphosphorylase activities Sphingomonas elodea dTTP + alpha-D-glucose 1-phosphate - ? 378670 2.7.7.24 dTTP + 2-deoxy-2-amino-alpha-D-glucose 1-phosphate - Streptococcus pneumoniae diphosphate + dTDP-2-deoxy-2-amino-alpha-D-glucose - ? 437521 2.7.7.24 dTTP + 3-deoxy-3-amino-alpha-D-glucose 1-phosphate - Streptococcus pneumoniae diphosphate + dTDP-3-deoxy-3-amino-alpha-D-glucose - ? 437522 2.7.7.24 dTTP + 3-deoxy-3-azido-alpha-D-glucose 1-phosphate - Streptococcus pneumoniae diphosphate + dTDP-3-deoxy-3-azido-alpha-D-glucose - ? 437523 2.7.7.24 dTTP + alpha-D-galactosamine 1-phosphate 5% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dTDP-alpha-D-galactosamine - ? 459638 2.7.7.24 dTTP + alpha-D-galactose 1-phosphate 12.6% of the activity with alpha-D-glucose 1-phosphate Streptomyces sp. dTDP-galactose + diphosphate - ? 379713 2.7.7.24 dTTP + alpha-D-galactose 1-phosphate 10% activity compared to alpha-D-glucose 1-phosphate Streptomyces sp. dTDP-galactose + diphosphate - r 379713 2.7.7.24 dTTP + alpha-D-galactose 1-phosphate 12.6% of the activity with alpha-D-glucose 1-phosphate Streptomyces sp. GERI-155 dTDP-galactose + diphosphate - ? 379713 2.7.7.24 dTTP + alpha-D-galactose 1-phosphate 10% activity compared to alpha-D-glucose 1-phosphate Streptomyces sp. SCC-2136 dTDP-galactose + diphosphate - r 379713 2.7.7.24 dTTP + alpha-D-galactose 1-phosphate 91% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dTDP-alpha-D-galactose - ? 459639 2.7.7.24 dTTP + alpha-D-galactose-1-phosphate 10% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. dTDP-galactose + diphosphate - ? 388632 2.7.7.24 dTTP + alpha-D-glucosamine 1-phosphate 23% activity compared to alpha-D-glucose 1-phosphate Streptomyces sp. dTDP-glucosamine + diphosphate - r 400901 2.7.7.24 dTTP + alpha-D-glucosamine 1-phosphate 71% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dTDP-alpha-D-glucosamine - ? 459640 2.7.7.24 dTTP + alpha-D-glucosamine-1-phosphate 23% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. dTDP-glucosamine + diphosphate - ? 388633 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Lactiplantibacillus plantarum dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Bacillus subtilis dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Escherichia coli dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Escherichia coli dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Mycolicibacterium smegmatis dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Mycolicibacterium smegmatis dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Glycine max dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Pseudomonas aeruginosa dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Pseudomonas aeruginosa dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Acinetobacter calcoaceticus dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Enterococcus faecalis dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Leuconostoc mesenteroides dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Mycobacterium tuberculosis dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Medicago sativa dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Micrococcus luteus dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Salmonella enterica dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Streptomyces antibioticus dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Streptococcus zymogenes dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Thermus caldophilus dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Streptomyces sp. dTDP-glucose + diphosphate highly specific for dTDP-glucose and diphosphate r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate 100% activity Streptomyces sp. dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate sequential mechanism Streptomyces globisporus dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate probably involved in conversion of D-glucose to L-rhamnose in the biosynthesis of deoxy compound Enterococcus faecalis dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate first enzyme of the dTDP-L-rhamnose synthesis pathway Pseudomonas aeruginosa dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate the enzyme catalyzes the first step in the biosynthesis of 4-deoxy-4-(dimethylamino)-5,5-dimethyl-D-ribopyranose moiety Streptomyces globisporus dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate in the opposite direction the enzyme is highly specific for dTDP-D-glucose and diphosphate Streptomyces sp. dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Leuconostoc mesenteroides P-60 dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium LT2 dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Streptomyces antibioticus Tu99 dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 dTDP-glucose + diphosphate - ? 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate in the opposite direction the enzyme is highly specific for dTDP-D-glucose and diphosphate Streptomyces sp. GERI-155 dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Streptomyces sp. SCC-2136 dTDP-glucose + diphosphate highly specific for dTDP-glucose and diphosphate r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate 100% activity Streptomyces sp. SCC-2136 dTDP-glucose + diphosphate - r 358468 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Mycobacterium tuberculosis diphosphate + dTDP-glucose - ? 423454 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Streptomyces peucetius dTDP-alpha-D-glucose + diphosphate - ? 423455 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Streptomyces peucetius ATCC 27952 dTDP-alpha-D-glucose + diphosphate - ? 423455 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Streptococcus pneumoniae diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Pyrococcus horikoshii diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Caenorhabditis elegans diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Sulfurisphaera tokodaii diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Sulfurisphaera tokodaii diphosphate + dTDP-alpha-D-glucose - r 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Campylobacter jejuni diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Bacillus anthracis diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Mycobacterium tuberculosis diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate maximal velocity of the reverse reaction is 11.4fold of the maximal velocity of the forward reaction. The multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.9, UTP-glucose-1-phosphate uridylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + N-acetylglucosamine 1-phosphate (N-acetylglucosamine 1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate Sulfurisphaera tokodaii diphosphate + dTDP-alpha-D-glucose - r 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate the enzyme also shows activity of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase Sulfurisphaera tokodaii diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate the enzyme is involved in biosynthesis of L-rhamnose Sulfurisphaera tokodaii diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose Campylobacter jejuni diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP Caenorhabditis elegans diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate 86% yield with 0.006 mM enzyme, 93% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Bacillus anthracis Ames diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate maximal velocity of the reverse reaction is 11.4fold of the maximal velocity of the forward reaction. The multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.9, UTP-glucose-1-phosphate uridylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + N-acetylglucosamine 1-phosphate (N-acetylglucosamine 1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate Sulfurisphaera tokodaii 7 diphosphate + dTDP-alpha-D-glucose - r 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate the enzyme also shows activity of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase Sulfurisphaera tokodaii 7 diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Sulfurisphaera tokodaii DSM 16993 diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Sulfurisphaera tokodaii DSM 16993 diphosphate + dTDP-alpha-D-glucose - r 426362 2.7.7.24 dTTP + alpha-D-glucose 1-phosphate - Mycobacterium tuberculosis H37Rv diphosphate + dTDP-alpha-D-glucose - ? 426362 2.7.7.24 dTTP + alpha-D-mannose 1-phosphate 11% activity compared to alpha-D-glucose 1-phosphate Streptomyces sp. dTDP-mannose + diphosphate - r 400903 2.7.7.24 dTTP + alpha-D-mannose 1-phosphate 88% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dTDP-alpha-D-mannose - ? 459641 2.7.7.24 dTTP + alpha-D-mannose-1-phosphate 11% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. dTDP-mannose + diphosphate - ? 388634 2.7.7.24 dTTP + [[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]methyl]phosphonic acid - Streptococcus pneumoniae diphosphate + dTDP-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]methyl]phosphonic acid - ? 437525 2.7.7.24 dUTP + alpha-D-galactose 1-phosphate 83% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dUDP-alpha-D-galactose - ? 459644 2.7.7.24 dUTP + alpha-D-glucose 1-phosphate 88% yield with 0.006 mM enzyme, 95% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + dUDP-alpha-D-glucose - ? 459645 2.7.7.24 GTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium GDP-glucose + diphosphate - ? 388855 2.7.7.24 GTP + alpha-D-glucose 1-phosphate - Pyrococcus horikoshii diphosphate + GDP-alpha-D-glucose - ? 445531 2.7.7.24 GTP + alpha-D-glucose 1-phosphate RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP Caenorhabditis elegans diphosphate + GDP-alpha-D-glucose - ? 445531 2.7.7.24 GTP + alpha-D-glucose 1-phosphate no product yield with 0.006 mM enzyme, 91% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + GDP-alpha-D-glucose - ? 445531 2.7.7.24 GTP + alpha-D-mannose 1-phosphate 13% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + GDP-alpha-D-mannose - ? 378688 2.7.7.24 additional information GTP, UTP/alpha-D-mannose-1-phosphate or UTP/alpha-D-galactose-1-phosphate are no substrates Streptomyces sp. ? - ? 89 2.7.7.24 additional information the enzyme shows 102% relative activity for dTMP or dTDP compared to dTTP at 2 mM, respectively Streptomyces sp. ? - ? 89 2.7.7.24 additional information almost no activity with ATP-D-glucose, CTP-D-glucose, UTP-D-Glucose, GTP, alpha-D-galactose-1-phosphate, and alpha-D-mannose-1-phosphate Streptomyces sp. ? - ? 89 2.7.7.24 additional information utilizes all eight naturally occurring NTPs with varying levels of catalytic efficiency, even in the presence of nonnative sugar-1-phosphates Salmonella enterica typhimurium ? - ? 89 2.7.7.24 additional information BtrD is inactive with ATP, GTP, or CTP Niallia circulans ? - ? 89 2.7.7.24 additional information the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms Sulfurisphaera tokodaii ? - ? 89 2.7.7.24 additional information no activity with alpha-D-galacturonic acid 1-phosphate Streptococcus pneumoniae ? - - 89 2.7.7.24 additional information utilizes all eight naturally occurring NTPs with varying levels of catalytic efficiency, even in the presence of nonnative sugar-1-phosphates Salmonella enterica typhimurium LT2 ? - ? 89 2.7.7.24 additional information the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms Sulfurisphaera tokodaii 7 ? - ? 89 2.7.7.24 additional information GTP, UTP/alpha-D-mannose-1-phosphate or UTP/alpha-D-galactose-1-phosphate are no substrates Streptomyces sp. SCC-2136 ? - ? 89 2.7.7.24 additional information the enzyme shows 102% relative activity for dTMP or dTDP compared to dTTP at 2 mM, respectively Streptomyces sp. SCC-2136 ? - ? 89 2.7.7.24 additional information almost no activity with ATP-D-glucose, CTP-D-glucose, UTP-D-Glucose, GTP, alpha-D-galactose-1-phosphate, and alpha-D-mannose-1-phosphate Streptomyces sp. SCC-2136 ? - ? 89 2.7.7.24 TTP + alpha-D-glucose 1-phosphate - Pseudomonas aeruginosa TDP-glucose + diphosphate - r 358469 2.7.7.24 UTP + 2-deoxy-2-amino-alpha-D-glucose 1-phosphate - Streptococcus pneumoniae diphosphate + UDP-2-deoxy-2-amino-alpha-D-glucose - ? 437962 2.7.7.24 UTP + alpha-D-galactose 1-phosphate 86% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + UDP-alpha-D-galactose - ? 422132 2.7.7.24 UTP + alpha-D-glucosamine 1-phosphate 8% activity compared to the reaction with alpha-D-glucose 1-phosphate and dTTP Streptomyces sp. UDP-glucosamine + diphosphate - r 402216 2.7.7.24 UTP + alpha-D-glucosamine 1-phosphate 12% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + UDP-alpha-D-glucosamine - ? 460008 2.7.7.24 UTP + alpha-D-glucosamine-1-phosphate 8% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. UDP-glucosamine + diphosphate - ? 390060 2.7.7.24 UTP + alpha-D-glucose 1-phosphate - Salmonella enterica UDP-glucose + diphosphate - ? 380412 2.7.7.24 UTP + alpha-D-glucose 1-phosphate - Salmonella enterica typhimurium UDP-glucose + diphosphate - ? 380412 2.7.7.24 UTP + alpha-D-glucose 1-phosphate 5.5% of the activity with dTTP Streptomyces sp. UDP-glucose + diphosphate - ? 380412 2.7.7.24 UTP + alpha-D-glucose 1-phosphate 12% activity compared to dTTP Streptomyces sp. UDP-glucose + diphosphate - r 380412 2.7.7.24 UTP + alpha-D-glucose 1-phosphate 5.5% of the activity with dTTP Streptomyces sp. GERI-155 UDP-glucose + diphosphate - ? 380412 2.7.7.24 UTP + alpha-D-glucose 1-phosphate 12% activity compared to dTTP Streptomyces sp. SCC-2136 UDP-glucose + diphosphate - r 380412 2.7.7.24 UTP + alpha-D-glucose 1-phosphate - Streptococcus pneumoniae diphosphate + UDP-alpha-D-glucose - ? 429422 2.7.7.24 UTP + alpha-D-glucose 1-phosphate - Pyrococcus horikoshii diphosphate + UDP-alpha-D-glucose - ? 429422 2.7.7.24 UTP + alpha-D-glucose 1-phosphate - Caenorhabditis elegans diphosphate + UDP-alpha-D-glucose - ? 429422 2.7.7.24 UTP + alpha-D-glucose 1-phosphate RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP Caenorhabditis elegans diphosphate + UDP-alpha-D-glucose - ? 429422 2.7.7.24 UTP + alpha-D-glucose 1-phosphate 40% yield with 0.006 mM enzyme, 94% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + UDP-alpha-D-glucose - ? 429422 2.7.7.24 UTP + alpha-D-glucose-1-phosphate 12% of the activity with dTTP and alpha-D-glucose 1-phosphate Streptomyces sp. UDP-glucose + diphosphate - ? 390061 2.7.7.24 UTP + alpha-D-mannose 1-phosphate 78% yield with 0.06 mM enzyme Streptococcus pneumoniae diphosphate + UDP-alpha-D-mannose - ? 460009 2.7.7.24 UTP + [[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]methyl]phosphonic acid - Streptococcus pneumoniae diphosphate + UMP-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]methyl]phosphonic acid - ? 437971