2.6.1.86 chorismate + L-glutamine - Pseudomonas fluorescens (2S)-2-amino-4-deoxychorismate + L-glutamate - 391662 2.6.1.86 chorismate + L-glutamine - Streptomyces globisporus (2S)-2-amino-4-deoxychorismate + L-glutamate - 391662 2.6.1.86 chorismate + L-glutamine the net conversion of chorismate to 3-enolpyruvoylanthranilate by the tandem action of SgcD and SgcG establishes a new branching point in chorismate metabolism leading to synthesis of C-1027, an enediyne antitumor antibiotic Streptomyces globisporus (2S)-2-amino-4-deoxychorismate + L-glutamate - 391662 2.6.1.86 chorismate + L-glutamine (2S)-2-amino-4-deoxychorismate is formed by a reversible, Mg2+-dependent ADIC synthase activity of anthranilate synthase (EC 4.1.3.27) that can be functionally uncoupled from a Mg2+-dependent ADIC lyase activity of the enzyme by single amino acid substitutions in the TrpE subunit of the anthranilate synthase complex of Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium (2S)-2-amino-4-deoxychorismate + L-glutamate - 391662 2.6.1.86 L-glutamine + chorismate - Burkholderia lata (S)-2-amino-2-deoxyisochorismate + L-glutamate - 426557 2.6.1.86 L-glutamine + chorismate - Burkholderia lata 383 (S)-2-amino-2-deoxyisochorismate + L-glutamate - 426557 2.6.1.86 L-glutamine + chorismate - Pseudomonas aeruginosa (S)-2-amino-2-deoxyisochorismate + glutamate - 426558 2.6.1.86 additional information the enzyme participates in the biosynthesis of phenazine, a precursor for several compounds with antibiotic activity Pseudomonas fluorescens ? - 89