2.4.99.20	2'-phospho-cyclic ADP-ribose + nicotinate	-	Mus musculus	nicotinate-adenine dinucleotide phosphate	-	?	425352	
2.4.99.20	2'-phospho-cyclic ADP-ribose + nicotinate	-	Oryctolagus cuniculus	nicotinate-adenine dinucleotide phosphate	-	?	425352	
2.4.99.20	2'-phospho-cyclic ADP-ribose + nicotinate	-	Homo sapiens	nicotinate-adenine dinucleotide phosphate	-	?	425352	
2.4.99.20	2'-phospho-cyclic ADP-ribose + nicotinate	-	Rattus norvegicus	nicotinate-adenine dinucleotide phosphate	-	?	425352	
2.4.99.20	2'-phospho-cyclic ADP-ribose + nicotinate	-	Aplysia californica	nicotinate-adenine dinucleotide phosphate	-	?	425352	
2.4.99.20	2'-phospho-cyclic ADP-ribose + nicotinate	-	Aplysia californica	nicotinate-adenine dinucleotide phosphate	enzyme shows a higher NAADP+-producing activity at pH 5.0 than at pH 7.4. At pH 5.0 the formation of NAADP+ is even more predominant than cADPRP hydrolysis, reaction of EC 3.2.2.6	?	425352	
2.4.99.20	2'-phospho-cyclic ADP-ribose + nicotinate	-	Axinella polypoides	nicotinate-adenine dinucleotide phosphate	enzyme shows a higher NAADP+-producing activity at pH 5.0 than at pH 7.4. At pH 5.0 the formation of NAADP+ is even more predominant than cADPRP hydrolysis, reaction of EC 3.2.2.6	?	425352	
2.4.99.20	2'-phospho-cyclic ADP-ribose + nicotinate	-	Homo sapiens	nicotinate-adenine dinucleotide phosphate	the synthesis of nicotinate-adenine dinucleotide phosphate from 2'-phospho-cyclic ADP-ribose is as efficient as the hydrolysis of the cyclic nucleotide at pH 5.0, reaction of EC 3.2.2.6, while at pH 7.4 the hydrolase activity is predominant	?	425352	
2.4.99.20	additional information	enzyme is more efficient in catalyzing the removal of the nicotinamide moiety than in the base-exchange reaction	Homo sapiens	?	-	?	89	
2.4.99.20	additional information	enzyme is more efficient in catalyzing the removal of the nicotinamide moiety than in the base-exchange reaction	Aplysia californica	?	-	?	89	
2.4.99.20	additional information	enzyme is more efficient in catalyzing the removal of the nicotinamide moiety than in the base-exchange reaction	Axinella polypoides	?	-	?	89	
2.4.99.20	additional information	enzymes cyclizes NAD to cADPR. In the presence of nicotinic acid, it catalyzes a base exchange reaction resulting in the synthesis of nicotinate-adenine dinucleotide phosphate from NADP+. The switch between these two modes of catalysis is regulated by pH	Homo sapiens	?	-	?	89	
2.4.99.20	additional information	enzymes cyclizes NAD to cADPR. In the presence of nicotinic acid, it catalyzes a base exchange reaction resulting in the synthesis of nicotinate-adenine dinucleotide phosphate from NADP+. The switch between these two modes of catalysis is regulated by pH	Aplysia californica	?	-	?	89	
2.4.99.20	additional information	in the absence of nicotinic acid or at neutral pH, isoform CD38 converts NADP+ to ADP-ribose 2'-phosphate, which is the hydrolysis product of cyclic ADPribose 2'-phosphate, reaction of EC 3.2.2.6	Aplysia californica	?	-	?	89	
2.4.99.20	additional information	the cyclization reaction to form cADPr and cGDPr as well as the base-exchange reaction to form nicotinic acid adenine dinucleotide phosphate are strictly dependent on pH. Although the formation of cyclic GDP-ribose is optimized at pH 6, the synthesis of nicotinic acid adenine dinucleotide phosphate is most pronounced at a pH below 5. Nicotinic acid has virtually no influence on the cyclization reaction, but increases the affinity of NADP at an acidic pH and has the opposite effect at alkaline pH	Oryctolagus cuniculus	?	-	?	89	
2.4.99.20	additional information	the switch of the catalysis to the exchange reaction requires acidic pH and nicotinic acid. In the absence of nicotinic acid or at neutral pH, the cyclase converts NADP+ to cyclic ADP-ribose 2'-phosphate	Homo sapiens	?	-	?	89	
2.4.99.20	NADP+	-	Oryctolagus cuniculus	2'-phospho-cyclic ADP-ribose + nicotinamide	-	?	428830	
2.4.99.20	NADP+	-	Homo sapiens	2'-phospho-cyclic ADP-ribose + nicotinamide	-	?	428830	
2.4.99.20	NADP+	-	Aplysia californica	2'-phospho-cyclic ADP-ribose + nicotinamide	-	?	428830	
2.4.99.20	NADP+	-	Axinella polypoides	2'-phospho-cyclic ADP-ribose + nicotinamide	-	?	428830	
2.4.99.20	NADP+ + nicotinate	-	Mus musculus	nicotinate-adenine dinucleotide phosphate + nicotinamide	nicotinic acid-adenine dinucleotide phosphate i.e. NAADP+	?	424933	
2.4.99.20	NADP+ + nicotinate	-	Rattus norvegicus	nicotinate-adenine dinucleotide phosphate + nicotinamide	nicotinic acid-adenine dinucleotide phosphate i.e. NAADP+	?	424933	
2.4.99.20	NADP+ + nicotinate	this multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	Rattus norvegicus	nicotinate-adenine dinucleotide phosphate + nicotinamide	-	?	424933	
2.4.99.20	NADP+ + nicotinate	this multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes	Mus musculus	nicotinate-adenine dinucleotide phosphate + nicotinamide	-	?	424933	
2.4.99.20	NGDP+	-	Oryctolagus cuniculus	2'-phospho-cyclic GDP-ribose + nicotinamide	-	?	428837	
2.4.99.20	NGDP+	enzyme cyclizes nicotinamide guanine dinucleotide to produce a fluorescent product, cyclic GDP-ribose, which has a site of cyclization different from cADPR	Homo sapiens	2'-phospho-cyclic GDP-ribose + nicotinamide	-	?	428837	
2.4.99.20	NGDP+	enzyme cyclizes nicotinamide guanine dinucleotide to produce a fluorescent product, cyclic GDP-ribose, which has a site of cyclization different from cADPR	Aplysia californica	2'-phospho-cyclic GDP-ribose + nicotinamide	-	?	428837