2.1.1.156	2 S-adenosyl-L-methionine + glycine	-	Methanohalophilus portucalensis	2 S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	422324	
2.1.1.156	2 S-adenosyl-L-methionine + glycine	overall reaction	Halorhodospira halochloris	2 S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	422324	
2.1.1.156	2 S-adenosyl-L-methionine + glycine	-	Methanohalophilus portucalensis FDF-1	2 S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	422324	
2.1.1.156	additional information	the enzyme catalyzes the first 2 steps of betaine synthesis from glycine in a 3-step process	Halorhodospira halochloris	?	-	?	89	
2.1.1.156	additional information	the enzyme catalyzes the first 2 steps of betaine synthesis from glycine in a 3-step process	Actinopolyspora halophila	?	-	?	89	
2.1.1.156	additional information	the enzyme catalyzes the first 2 steps of glycine betaine synthesis from glycine in a 3-step process, betaine is required for balancing osmotic pressure under high salt living conditions	Halorhodospira halochloris	?	-	?	89	
2.1.1.156	additional information	the enzyme is involved in the alternate biosynthesis of betaine, which is an important osmoprotectant and is synthesized in response to abiotic stress	Aphanothece halophytica	?	-	?	89	
2.1.1.156	additional information	enzyme shows strict substrate specificity	Aphanothece halophytica	?	-	?	89	
2.1.1.156	additional information	the enzyme has overlapping activities with the enzyme catalyzing the following reaction steps	Halorhodospira halochloris	?	-	?	89	
2.1.1.156	additional information	the enzyme has overlapping activities with the enzyme catalyzing the following reaction steps	Actinopolyspora halophila	?	-	?	89	
2.1.1.156	additional information	the enzyme shows strict specificity for glycine and sarcosine as substrates, no activity with ethanolamine, monomethylethanolamine, nor several L-amino acid, overview	Halorhodospira halochloris	?	-	?	89	
2.1.1.156	additional information	several other amino acids tested as substrates and non of them serves as methyl group acceptor	Parasynechococcus marenigrum WH 8102	?	-	?	89	
2.1.1.156	additional information	the broad substrate methyltransferase, glycine sarcosine dimethylglycine methyltransferase, GSDMT, purified from the halophilic methanoarchaeon Methanohalophilus portucalensis strain FDF1, has been shown to possess glycine N-methyltransferase (GMT), sarcosine N-methyltransferase (SMT) and dimethylglycine N-methyltransferase (DMT) activities. GSMT possesses glycine N-methyltransferase (GMT) and sarcosine N-methyltransferase (SMT) activities	Methanohalophilus portucalensis	?	-	?	89	
2.1.1.156	additional information	the enzyme from Methanohalophilus portucalensis possesses glycine N-methyltransferase (GMT) and sarcosine N-methyltransferase (SMT) activities	Methanohalophilus portucalensis	?	-	?	89	
2.1.1.156	additional information	the broad substrate methyltransferase, glycine sarcosine dimethylglycine methyltransferase, GSDMT, purified from the halophilic methanoarchaeon Methanohalophilus portucalensis strain FDF1, has been shown to possess glycine N-methyltransferase (GMT), sarcosine N-methyltransferase (SMT) and dimethylglycine N-methyltransferase (DMT) activities. GSMT possesses glycine N-methyltransferase (GMT) and sarcosine N-methyltransferase (SMT) activities	Methanohalophilus portucalensis FDF1	?	-	?	89	
2.1.1.156	additional information	the enzyme from Methanohalophilus portucalensis possesses glycine N-methyltransferase (GMT) and sarcosine N-methyltransferase (SMT) activities	Methanohalophilus portucalensis FDF1	?	-	?	89	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Myxococcus xanthus	S-adenosyl-L-homocysteine + sarcosine	-	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Aphanothece halophytica	S-adenosyl-L-homocysteine + sarcosine	-	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Halorhodospira halochloris	S-adenosyl-L-homocysteine + sarcosine	-	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Actinopolyspora halophila	S-adenosyl-L-homocysteine + sarcosine	-	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Methanohalophilus portucalensis	S-adenosyl-L-homocysteine + sarcosine	-	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Halorhodospira halochloris	S-adenosyl-L-homocysteine + sarcosine	i.e. 2-methylglycine	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Aphanothece halophytica	S-adenosyl-L-homocysteine + sarcosine	i.e. 2-methylglycine	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	the recombinant enzyme from Escherichia coli is 3.3fold less active than the wild-type enzyme	Halorhodospira halochloris	S-adenosyl-L-homocysteine + sarcosine	i.e. 2-methylglycine	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Methanohalophilus portucalensis FDF-1	S-adenosyl-L-homocysteine + sarcosine	-	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Methanohalophilus portucalensis FDF1	S-adenosyl-L-homocysteine + sarcosine	-	?	319640	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Aphanothece halophytica	S-adenosyl-L-homocysteine + N-methylglycine	-	?	386682	
2.1.1.156	S-adenosyl-L-methionine + glycine	-	Parasynechococcus marenigrum WH 8102	S-adenosyl-L-homocysteine + N-methylglycine	-	?	386682	
2.1.1.156	S-adenosyl-L-methionine + glycine	synthesis of the compatible solute betaine de novo through the methylation of glycine, sarcosine and dimethylglycine with the methyl group from S-adenosylmethionine	Aphanothece halophytica	S-adenosyl-L-homocysteine + N-methylglycine	-	?	386682	
2.1.1.156	S-adenosyl-L-methionine + glycine	synthesis of the compatible solute betaine de novo through the methylation of glycine, sarcosine and dimethylglycine with the methyl group from S-adenosylmethionine	Parasynechococcus marenigrum WH 8102	S-adenosyl-L-homocysteine + N-methylglycine	-	?	386682	
2.1.1.156	S-adenosyl-L-methionine + N-methylglycine	-	Aphanothece halophytica	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	386685	
2.1.1.156	S-adenosyl-L-methionine + N-methylglycine	-	Parasynechococcus marenigrum WH 8102	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	386685	
2.1.1.156	S-adenosyl-L-methionine + N-methylglycine	synthesis of the compatible solute betaine de novo through the methylation of glycine, sarcosine and dimethylglycine with the methyl group from S-adenosylmethionine	Aphanothece halophytica	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	386685	
2.1.1.156	S-adenosyl-L-methionine + N-methylglycine	synthesis of the compatible solute betaine de novo through the methylation of glycine, sarcosine and dimethylglycine with the methyl group from S-adenosylmethionine	Parasynechococcus marenigrum WH 8102	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	386685	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	-	Myxococcus xanthus	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	-	Aphanothece halophytica	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	-	Halorhodospira halochloris	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	-	Actinopolyspora halophila	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	-	Methanohalophilus portucalensis	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	i.e. 2-methylglycine	Actinopolyspora halophila	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	the recombinant enzyme from Escherichia coli is 2.5fold less active than the wild-type enzyme	Halorhodospira halochloris	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	-	Methanohalophilus portucalensis FDF-1	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296	
2.1.1.156	S-adenosyl-L-methionine + sarcosine	-	Methanohalophilus portucalensis FDF1	S-adenosyl-L-homocysteine + N,N-dimethylglycine	-	?	375296