2.1.1.117	additional information	enzyme catalyzes O-methylation at C-9 and C-2, and O-methylation events occur first at C-9 and then at C-2	Stephania intermedia	?	-	-	89	
2.1.1.117	additional information	enzyme is a scoulerine-9-O-methyltransferase for the biosynthesis of chelerythrine in California poppy, it produces 7-O-methylated, 3'-O-methylated and dual O-methylated products from reticuline and norreticuline, and 9-O-methylated tetrahydrocolumbamine, 2-O-methylscoulerine and tetrahydropalmatine from scoulerine	Eschscholzia californica subsp. californica	?	-	-	89	
2.1.1.117	S-adenosyl-L-homocysteine + (S)-tetrahydropalmatrubine	-	Stephania intermedia	S-adenosyl-L-homocysteine + (S)-tetrahydropalmatine	-	?	456353	
2.1.1.117	S-Adenosyl-L-methionine + (R,S)-2,3,9,10-tetrahydroxytetrahydroprotoberberine	methylated at 50% of the rate of (S)-scoulerine	Berberis wilsoniae	?	-	?	6870	
2.1.1.117	S-Adenosyl-L-methionine + (S)-3,9-dihydroxy-2,10-dimethoxytetrahydroprotoberberine	methylated at 4% of the rate of (S)-scoulerine	Berberis wilsoniae	?	-	?	6871	
2.1.1.117	S-adenosyl-L-methionine + (S)-norreticuline	-	Eschscholzia californica subsp. californica	S-adenosyl-L-homocysteine + norcodamine + norlaudanine	-	?	456364	
2.1.1.117	S-adenosyl-L-methionine + (S)-reticuline	-	Eschscholzia californica subsp. californica	S-adenosyl-L-homocysteine + codamine + laudanine	-	?	456366	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Papaver somniferum	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	?	6866	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Berberis stolonifera	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	?	6866	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Berberis wilsoniae	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	?	6866	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Coptis japonica	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	?	6866	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Coptis chinensis	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	ir	6866	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Coptis teeta	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	?	6866	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Stephania intermedia	S-Adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine	-	?	6866	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	-	Berberis stolonifera	?	-	?	369509	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	the enzyme is responsible for a late step in the biosynthesis of berberine	Coptis japonica	?	-	?	369509	
2.1.1.117	S-Adenosyl-L-methionine + (S)-scoulerine	central role in orotoberberine biosynthesis	Berberis wilsoniae	?	-	?	369509	
2.1.1.117	S-adenosyl-L-methionine + (S)-scoulerine	-	Eschscholzia californica subsp. californica	S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine + 2-O-methylscoulerine + tetrahydropalmatine	-	?	456367	
2.1.1.117	S-adenosyl-L-methionine + (S)-tetrahydrocolumbamine	-	Stephania intermedia	S-adenosyl-L-homocysteine + (S)-tetrahydropalmatine	-	?	456368	
2.1.1.117	S-Adenosyl-L-methionine + 6-O-methylnorlaudanosoline	8% of the activity relative to (S)-scoulerine	Coptis japonica	?	-	?	6868	
2.1.1.117	S-Adenosyl-L-methionine + norlaudanosoline	2% of the activity relative to (S)-scoulerine	Coptis japonica	?	-	?	6867	
2.1.1.117	S-Adenosyl-L-methionine + norreticuline	9% of the activity relative to (S)-scoulerine	Coptis japonica	?	-	?	6869