1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Desulfovibrio vulgaris	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Desulfosporosinus orientis	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Chlorobium phaeobacteroides	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Thermaerobacter marianensis	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Desulfitobacterium dichloroeliminans	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Chlorobium phaeobacteroides DSM 266	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Desulfovibrio vulgaris DP4	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Chlorobium phaeobacteroides BS1	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Desulfitobacterium dichloroeliminans LMG P-21439	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Desulfosporosinus orientis DSM 765	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Desulfovibrio vulgaris Hildenborough	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydrogen sulfide + a [DsrC protein]-disulfide + acceptor + H2O	-	Thermaerobacter marianensis AB011495	sulfite + a [DsrC protein]-dithiol + reduced acceptor + H+	-	?	440270	
1.8.99.5	hydroxylamine + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+	-	Desulfovibrio vulgaris	? + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O	-	?	433829	
1.8.99.5	hydroxylamine + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+	-	Clostridium pasteurianum	? + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O	50% of the activity with sulfite	?	433829	
1.8.99.5	hydroxylamine + a [DsrC protein]-dithiol + 2 reduced acceptor + 2 H+	-	Desulfovibrio vulgaris Hildenborough	? + a [DsrC protein]-disulfide + 2 acceptor + 3 H2O	-	?	433829	
1.8.99.5	additional information	no substrates: S3O62-, S2O32-. Methyl viologen is as effective as ferredoxin in coupling the sulfite reductase with hydrogenase while benzyl viologen is only 16% as effective as ferredoxin. No activity is observed with NAD, NADP, FAD or FMN. Varying the substrate concentration [SO 2-] from 1 to 2.5 micromol affects the stoichiometry of the enzyme reaction by alteration of the ratio of H2 uptake to S2- formed from 2.5:1 to 3.1:1	Clostridium pasteurianum	?	-	?	89	
1.8.99.5	additional information	two-state hypothesis for enzyme activity: an active form (DVa) binds and catalyzes substrate reduction, and an inactive form (DVi) exists for the resting enzyme. Only the active form of the enzyme need be considered during steady-state turnover. Determination of the rate constants defining these structural perturbations, from oxidized to reduced and reduced to oxidized states	Desulfovibrio vulgaris	?	-	?	89	
1.8.99.5	additional information	multiheme cytochrome c enzymes catalyse complex-multi-electron redox reactions and bind their substrates through the free electron pairs of a heteroatom to a free coordination position at an active-site hem group. Electrons are then provided or accepted by the tightly coupled chain of heme groups	Wolinella succinogenes	?	-	?	89	
1.8.99.5	additional information	MccA reduces sulfite, but not arsenate, selenate, selenite, hydroxylamine, hydrazine, fumarate, nitrate, thiosulfate, tetrathionate, polysulfide, or Fe(III). Nitrite is reduced only very slowly to ammonium	Wolinella succinogenes	?	-	?	89	
1.8.99.5	additional information	the enzyme catalyzes the reduction of sulfite to sulfide	Cryptococcus neoformans var. neoformans	?	-	-	89	
1.8.99.5	additional information	the enzyme catalyzes the reduction of sulfite to sulfide	Cryptococcus neoformans var. neoformans ATCC MYA-565	?	-	-	89	
1.8.99.5	additional information	the enzyme catalyzes the reduction of sulfite to sulfide	Cryptococcus neoformans var. neoformans JEC21	?	-	-	89	
1.8.99.5	additional information	two-state hypothesis for enzyme activity: an active form (DVa) binds and catalyzes substrate reduction, and an inactive form (DVi) exists for the resting enzyme. Only the active form of the enzyme need be considered during steady-state turnover. Determination of the rate constants defining these structural perturbations, from oxidized to reduced and reduced to oxidized states	Desulfovibrio vulgaris Hildenborough	?	-	?	89	
1.8.99.5	nitrite + a [DsrC protein]-dithiol + 2 reduced acceptor	-	Desulfovibrio vulgaris	? + a [DsrC protein]-disulfide + 2 acceptor + 2 H2O	-	?	434065	
1.8.99.5	nitrite + a [DsrC protein]-dithiol + 2 reduced acceptor	-	Clostridium pasteurianum	? + a [DsrC protein]-disulfide + 2 acceptor + 2 H2O	25% of the activity with sulfite	?	434065	
1.8.99.5	nitrite + a [DsrC protein]-dithiol + 2 reduced acceptor	-	Desulfovibrio vulgaris Hildenborough	? + a [DsrC protein]-disulfide + 2 acceptor + 2 H2O	-	?	434065	
1.8.99.5	SeO32- + a [DsrC protein]-dithiol + 2 reduced methyl viologen + 2 H+	-	Clostridium pasteurianum	HSe- + a [DsrC protein]-disulfide + 2 oxidized methyl viologen + 3 H2O	40% of the activity with sulfite	?	434392	
1.8.99.5	sulfite + 6 ferrocytochrome c + 6 H+	overall transfer of 6 electrons during the reaction	Wolinella succinogenes	sulfide + 6 ferricytochrome c + 3 H2O	-	?	440405	
1.8.99.5	sulfite + a [DsrC protein]-dithiol + 2 reduced ferredoxin + 2 H+	-	Clostridium pasteurianum	hydrogen sulfide + a [DsrC protein]-disulfide + 2 oxidized ferredoxin + 3 H2O	overall reaction	?	434417	
1.8.99.5	sulfite + a [DsrC protein]-dithiol + 2 reduced ferredoxin + 2 H+	-	Desulfovibrio vulgaris	hydrogen sulfide + a [DsrC protein]-disulfide + 2 oxidized ferredoxin + 3 H2O	overall reaction	?	434417	
1.8.99.5	sulfite + a [DsrC protein]-dithiol + 2 reduced ferredoxin + 2 H+	-	Desulfovibrio vulgaris Hildenborough	hydrogen sulfide + a [DsrC protein]-disulfide + 2 oxidized ferredoxin + 3 H2O	overall reaction	?	434417	
1.8.99.5	sulfite + a [DsrC protein]-dithiol + reduced methyl viologen	-	Thermodesulfobacterium commune	trithionate + a [DsrC protein]-disulfide + oxidized methyl viologen	trithionate is the major product with reduced methyl viologen as electron donor	?	434418	
1.8.99.5	sulfite + a [DsrC protein]-dithiol + reduced methyl viologen	-	Desulfocurvibacter africanus	trithionate + a [DsrC protein]-disulfide + oxidized methyl viologen	trithionate is the major product, plus formation of thiosulfate and sulfid	?	434418	
1.8.99.5	sulfite + a [DsrC protein]-dithiol + reduced methyl viologen	-	Desulfocurvibacter africanus Benghazi	trithionate + a [DsrC protein]-disulfide + oxidized methyl viologen	trithionate is the major product, plus formation of thiosulfate and sulfid	?	434418