1.7.2.5 2 nitric oxide + 2 ferrocytochrome c + 2 H+ - Paracoccus denitrificans nitrous oxide + 2 ferricytochrome c + H2O - ? 440076 1.7.2.5 2 nitric oxide + 2 ferrocytochrome c + 2 H+ - Pseudomonas aeruginosa nitrous oxide + 2 ferricytochrome c + H2O - ? 440076 1.7.2.5 2 nitric oxide + 2 ferrocytochrome c + 2 H+ - Thermus thermophilus nitrous oxide + 2 ferricytochrome c + H2O - ? 440076 1.7.2.5 2 nitric oxide + 2 ferrocytochrome c + 2 H+ - Pyrodictium delaneyi nitrous oxide + 2 ferricytochrome c + H2O - ? 440076 1.7.2.5 2 nitric oxide + 2 ferrocytochrome c + 2 H+ - Thermus thermophilus PRQ25 nitrous oxide + 2 ferricytochrome c + H2O - ? 440076 1.7.2.5 2 nitric oxide + 2 ferrocytochrome c + 2 H+ - Pyrodictium delaneyi Su06 nitrous oxide + 2 ferricytochrome c + H2O - ? 440076 1.7.2.5 2 nitric oxide + 2 reduced bovine heart cytochrome c + 2 H+ - Paracoccus denitrificans nitrous oxide + 2 oxidized bovine heart cytochrome c + H2O - ? 461900 1.7.2.5 2 nitric oxide + reduced acceptor - Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Thermus thermophilus nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Escherichia coli nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Bradyrhizobium japonicum nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Pseudomonas aeruginosa nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Pseudomonas stutzeri nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Cupriavidus necator nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Pseudomonas denitrificans (nom. rej.) nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Cutaneotrichosporon cutaneum nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Agrobacterium tumefaciens nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Desulfovibrio vulgaris nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Synechocystis sp. nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Fusarium oxysporum nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Fungi nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Achromobacter cycloclastes nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Halomonas halodenitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Fusarium lichenicola nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Roseobacter denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor mechanism Pseudomonas aeruginosa nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor phenazine methosulfate and dithiothreitol as electron donors Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor reduced menadione as electron donor Synechocystis sp. nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor NADH, succinate or ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors in membrane vesicles Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c Pseudomonas stutzeri nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c Achromobacter cycloclastes nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor as electron donors phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine, N,N,N',N'-tetramethyl-1,4-benzendiamine together with horse cytochrome c Halomonas halodenitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ferrocytochrome c-550 as electron donor Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor lactate, leuco-forms of thionine, brilliant cresyl blue and methylene blue as electron donors Pseudomonas denitrificans (nom. rej.) nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate/phenazine methosulfate, N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate, 2,3,5,6-tetramethyl-1,4-benzendiamine/ascorbate and NADH as electron donors Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors Pseudomonas aeruginosa nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors Pseudomonas stutzeri nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors Achromobacter cycloclastes nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor investigation of proton and electron pathways, electron-transfer pathways are similar to those in oxygen-reducing heme-copper oxidases Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor NADH, succinate or isoascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate, phenazine methosulfate and horse heart cytochrome c as the electron donor/mediator system Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate/phenazine methosulfate as electron donors Pseudomonas stutzeri nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate/phenazine methosulfate as electron donors Halomonas halodenitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor isoascorbate/2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors and horse heart cytochrome c as mediator Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor quinol-oxidising enzyme Staphylococcus aureus nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor quinol-oxidising enzyme Geobacillus stearothermophilus nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor quinol-oxidising enzyme Neisseria gonorrhoeae nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor quinol-oxidising enzyme Neisseria meningitidis nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor quinol-oxidising enzyme Mycobacterium avium nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor quinol-oxidising enzyme Cupriavidus necator nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor quinol-oxidising enzyme Synechocystis sp. nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor quinol-oxidising enzyme Corynebacterium diphtheriae nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate and phenazine methosulfate, NADH, NADH/menadione, NADH/duroquinone, NADH/2,3-dimethoxy-5-methyl-1,4-benzoquinone and N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors Cupriavidus necator nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Alcaligenes faecalis nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Cereibacter sphaeroides nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Bradyrhizobium japonicum nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Pseudomonas aeruginosa nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Pseudomonas sp. nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Pseudomonas stutzeri nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Halomonas halodenitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor NAD(P)H and NAD(P)+ as electron donor/acceptor Fusarium oxysporum nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor NAD(P)H and NAD(P)+ as electron donor/acceptor Fungi nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor NAD(P)H and NAD(P)+ as electron donor/acceptor Fusarium lichenicola nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor key step in the pathway of denitrification that uses N-oxyanions and N-oxides as respiratory electron acceptors Paracoccus denitrificans nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor To degrade NO, FlRd has to be reduced by NADH via the FAD-binding protein flavorubredoxin reductase. NADH, but not NADPH, quickly reduces the FlRd-reductase. The reductase in turn quickly reduces the rubredoxin (Rd) center of FlRd Escherichia coli nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Bradyrhizobium japonicum USDA 110 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Paracoccus denitrificans NCIB 8944 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor N,N,N',N'-tetramethyl-1,4-benzendiamine/ascorbate as electron donors Paracoccus denitrificans NCIB 8944 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Bradyrhizobium japonicum USDA 6 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Paracoccus denitrificans Pd 1222 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate, phenazine methosulfate and horse heart cytochrome c as the electron donor/mediator system Paracoccus denitrificans Pd 1222 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor cytochrome c as mediator Paracoccus denitrificans Pd 1222 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Agrobacterium tumefaciens C58 / ATCC 33970 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Paracoccus denitrificans 93.11 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor key step in the pathway of denitrification that uses N-oxyanions and N-oxides as respiratory electron acceptors Paracoccus denitrificans 93.11 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Pseudomonas aeruginosa PAO 1 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors Pseudomonas aeruginosa PAO 1 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 2 nitric oxide + reduced acceptor - Cutaneotrichosporon cutaneum JCM 2391 nitrous oxide + acceptor + H2O - ? 260660 1.7.2.5 additional information both toxin Dtx and nitric oxide reductase are the two key players required for survival and pathogenesis of Corynebacterium diphtheriae, their expressions being controlled by two independent regulators DtxR and DIP1512 respectively. The controlling system appears to be decoupled because of differential affinities of the two regulators for NO Corynebacterium diphtheriae ? - ? 89 1.7.2.5 additional information Pseudomonas aeruginosa NO reductase may contribute to the intracellular survival by acting as a counter component against the host’s defense systems Pseudomonas aeruginosa ? - ? 89 1.7.2.5 additional information the dissimilative nitrate respiration regulator DNR is involved in transcription regulation of the enzyme, apo-DNR binds heme in vitro and the heme-bound form reacts with carbon monoxide and NO, thus supporting the hypothesis that NO sensing involves gas binding to the ferrous heme, mechanism and structure, overview Pseudomonas aeruginosa ? - ? 89 1.7.2.5 additional information all-atom molecular dynamics simulations within an explicit membrane/solvent environment reveal two possible proton transfer pathways leading from the periplasm to the active site, while no pathways from the cytoplasmic side are found, consistently with the experimental observations that the enzyme is not a proton pump. One of the pathways is blocked in the crystal structure and requires small structural rearrangements to allow for water channel formation. That pathway is equivalent to the functional periplasmic cavity postulated in cbb3 oxidase Pseudomonas aeruginosa ? - ? 89 1.7.2.5 additional information quantumchemical calculations show that the reduction of the NO molecules by the enzyme and the formation of N2O are very exergonic steps, making the rereduction of the enzyme endergonic and rate-limiting for the entire catalytic cycle. Therefore the NO reduction cannot be electrogenic, i.e. cannot take electrons and protons from the opposite sides of the membrane, since it would increase the endergonicity of the rereduction when the gradient is present, thereby increasing the rate-limiting barrier, and the reaction would become too slow. It also means that proton pumping coupled to electron transfer is not possible in cytochrome c-dependent nitric oxide reductase Pseudomonas aeruginosa ? - ? 89 1.7.2.5 additional information NO reduction takes place in the NorB subunit that contains three redox centers: two b-type hemes (hemes b and b3) and a non-heme iron (FeB). Heme b3 and the non-heme iron form the binuclear center, where nitric oxide is bound and reduced. Determination of reduction rates of the cNOR variants with O2 and NO Paracoccus denitrificans ? - ? 89 1.7.2.5 additional information all-atom molecular dynamics simulations within an explicit membrane/solvent environment reveal two possible proton transfer pathways leading from the periplasm to the active site, while no pathways from the cytoplasmic side are found, consistently with the experimental observations that the enzyme is not a proton pump. One of the pathways is blocked in the crystal structure and requires small structural rearrangements to allow for water channel formation. That pathway is equivalent to the functional periplasmic cavity postulated in cbb3 oxidase Pseudomonas aeruginosa ATCC 15692 ? - ? 89 1.7.2.5 N2O + acceptor + H2O - Pseudomonas aeruginosa NO + reduced acceptor - r 398954 1.7.2.5 N2O + phenazine methosulfate + H2O - Pseudomonas stutzeri NO + reduced phenazine methosulfate - ? 401506 1.7.2.5 N2O + phenazine methosulfate + H2O using NO donor sodium nitroprusside and a N2 atmosphere in presence of NADH Pseudomonas aeruginosa NO + reduced phenazine methosulfate - r 401506 1.7.2.5 nitric oxide + ferrocytochrome c552 - Marinobacter nauticus nitrous oxide + ferricytochrome c552 + H2O - ? 406137 1.7.2.5 nitric oxide + NAD(P)H + H+ cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification Cutaneotrichosporon cutaneum nitrous oxide + NAD(P)+ + H2O - ? 394932 1.7.2.5 nitric oxide + NADH - Fusarium oxysporum nitrous oxide + NAD+ + H2O - ? 389390 1.7.2.5 nitric oxide + NADH + H+ cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification Fusarium oxysporum nitrous oxide + NAD+ - ? 394933 1.7.2.5 nitric oxide + NADH + H+ - Fusarium lichenicola nitrous oxide + NAD+ + H2O - r 394934 1.7.2.5 nitric oxide + NADH + H+ cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification Aspergillus oryzae nitrous oxide + NAD+ + H2O - ? 394934 1.7.2.5 nitric oxide + NADH + H+ cytochrome P450nor is a nitric oxide reductase involved in fungal denitrification Fusarium lichenicola nitrous oxide + NAD+ + H2O - ? 394934 1.7.2.5 nitric oxide + oxidized acceptor + H+ - Paracoccus denitrificans nitrous oxide + reduced acceptor + H2O - ? 406138 1.7.2.5 nitric oxide + reduced acceptor - Neisseria gonorrhoeae nitrous oxide + oxidized acceptor + H2O - ? 406139 1.7.2.5 nitric oxide + reduced acceptor - Marinobacter nauticus nitrous oxide + oxidized acceptor + H2O - ? 406139 1.7.2.5 nitric oxide + reduced acceptor - Neisseria gonorrhoeae F62 nitrous oxide + oxidized acceptor + H2O - ? 406139 1.7.2.5 nitric oxide + reduced ascorbate - Marinobacter nauticus nitrous oxide + oxidized ascorbate + H2O - ? 406140 1.7.2.5 nitric oxide + reduced cytochrome c - Hydrogenobacter thermophilus nitrous oxide + cytochrome c + H2O - ? 389391 1.7.2.5 nitric oxide + reduced cytochrome c - Hydrogenobacter thermophilus TK-6 / IAM 12695 nitrous oxide + cytochrome c + H2O - ? 389391 1.7.2.5 nitric oxide + reduced N,N,N',N'-tetramethyl-p-phenylenediamine - Paracoccus denitrificans nitrous oxide + oxidized N,N,N',N'-tetramethyl-p-phenylenediamine + H2O - ? 406141 1.7.2.5 nitric oxide + reduced N,N,N',N'-tetramethyl-p-phenylenediamine - Paracoccus denitrificans 93.11 nitrous oxide + oxidized N,N,N',N'-tetramethyl-p-phenylenediamine + H2O - ? 406141 1.7.2.5 nitric oxide + reduced phenazine methosulfate - Paracoccus denitrificans nitrous oxide + oxidized phenazine methosulfate + H2O - ? 406142 1.7.2.5 nitric oxide + reduced phenazine methosulfate - Paracoccus denitrificans 93.11 nitrous oxide + oxidized phenazine methosulfate + H2O - ? 406142 1.7.2.5 nitric oxide + reduced pseudoazurin - Paracoccus denitrificans nitrous oxide + pseudoazurin + H2O - ? 386614 1.7.2.5 nitric oxide + reduced pseudoazurin - Paracoccus denitrificans nitrous oxide + oxidized pseudoazurin + H2O - ? 406143 1.7.2.5 nitric oxide + reduced pseudoazurin - Paracoccus denitrificans 93.11 nitrous oxide + oxidized pseudoazurin + H2O - ? 406143 1.7.2.5 nitrous oxide + 2 ferricytochrome c + H2O - Pseudomonas aeruginosa 2 nitric oxide + 2 ferrocytochrome c + 2 H+ - ? 440363 1.7.2.5 NO + 5-hydroxy-1,4-naphthoquinol - Schinkia azotoformans N2O + H2O + 5-hydroxy-1,4-naphthoquinone - ? 377380 1.7.2.5 NO + 5-hydroxy-2-methyl-1,4-naphthoquinol - Schinkia azotoformans N2O + H2O + 5-hydroxy-2-methyl-1,4-naphthoquinone - ? 377381 1.7.2.5 NO + menaquinol - Schinkia azotoformans N2O + H2O + menaquinone - ? 375212 1.7.2.5 NO + NADH - Fusarium oxysporum N2O + H2O + NAD+ - ? 375213 1.7.2.5 NO + NADH - Aspergillus oryzae N2O + H2O + NAD+ - ? 375213 1.7.2.5 NO + NADH NADH is preferred over NADPH Aspergillus oryzae N2O + H2O + NAD+ - ? 375213 1.7.2.5 NO + NADH very little activity with NADPH Fusarium oxysporum N2O + H2O + NAD+ - ? 375213 1.7.2.5 NO + NADH - Aspergillus oryzae OSI 1013 N2O + H2O + NAD+ - ? 375213 1.7.2.5 NO + NADH NADH is preferred over NADPH Aspergillus oryzae OSI 1013 N2O + H2O + NAD+ - ? 375213 1.7.2.5 NO + NADH - Fusarium oxysporum MT-811 N2O + H2O + NAD+ - ? 375213 1.7.2.5 NO + NADH very little activity with NADPH Fusarium oxysporum MT-811 N2O + H2O + NAD+ - ? 375213 1.7.2.5 NO + NADPH - Aspergillus oryzae N2O + H2O + NADP+ - ? 375214 1.7.2.5 NO + NADPH - Aspergillus oryzae OSI 1013 N2O + H2O + NADP+ - ? 375214 1.7.2.5 NO + reduced acceptor - Paracoccus denitrificans N2O + H2O + acceptor - ? 375215 1.7.2.5 NO + reduced acceptor - Escherichia coli N2O + H2O + acceptor - ? 375215 1.7.2.5 NO + reduced acceptor - Nitrosomonas europaea N2O + H2O + acceptor - ? 375215 1.7.2.5 NO + reduced acceptor - Moorella thermoacetica N2O + H2O + acceptor - ? 375215 1.7.2.5 NO + reduced acceptor - Schinkia azotoformans N2O + H2O + acceptor - ? 375215 1.7.2.5 NO + reduced acceptor FlRd may protect Escherichia coli against NO, catalyzing the anaerobic reduction of NO to N2O Escherichia coli N2O + H2O + acceptor - ? 375215 1.7.2.5 NO + reduced cytochrome c551 - Schinkia azotoformans N2O + H2O + oxidized cytochrome c551 - ? 377387 1.7.2.5 O2 + reduced acceptor + H+ - Paracoccus denitrificans H2O + oxidized acceptor - ? 406220 1.7.2.5 O2 + reduced cytochrome c - Paracoccus denitrificans H2O + cytochrome c - ? 389432