1.1.1.3 L-aspartate 4-semialdehyde + NADPH - Arabidopsis thaliana L-homoserine + NADP+ - ? 371007 1.1.1.3 L-homoserine + NADP+ - Arabidopsis thaliana L-aspartate 4-semialdehyde + NADPH - ? 371012 1.1.1.3 L-homoserine + NADP+ - Arabidopsis thaliana L-aspartate 4-semialdehyde + NADPH - r 371012 1.1.1.3 L-homoserine + NADP+ - Bacillus subtilis L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NADP+ the binding of L-homoserine is the rate limiting factor for L-homoserine oxidation Bacillus subtilis L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 additional information enzyme BsHSD exclusively prefers NADP+ to NAD+ Bacillus subtilis ? - - 89 1.1.1.3 L-homoserine + NADP+ - Bacillus subtilis 168 L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NADP+ the binding of L-homoserine is the rate limiting factor for L-homoserine oxidation Bacillus subtilis 168 L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 additional information enzyme BsHSD exclusively prefers NADP+ to NAD+ Bacillus subtilis 168 ? - - 89 1.1.1.3 L-homoserine + NADP+ - Candida albicans L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NADP+ - Candida albicans SC5314 / ATCC MYA-2876 L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NAD(P)+ - Corynebacterium glutamicum L-aspartate 4-semialdehyde + NAD(P)H - ? 165090 1.1.1.3 L-homoserine + NAD+ - Corynebacterium glutamicum L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NAD+ - Corynebacterium glutamicum ATCC 13032 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum ATCC 13032 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 L-homoserine + NAD+ - Corynebacterium glutamicum BCRC 11384 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum BCRC 11384 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 L-homoserine + NAD+ - Corynebacterium glutamicum DSM 20300 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum DSM 20300 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum IWJ001 L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NAD+ - Corynebacterium glutamicum JCM 1318 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum JCM 1318 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 L-homoserine + NAD+ - Corynebacterium glutamicum LMG 3730 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum LMG 3730 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 L-homoserine + NAD+ - Corynebacterium glutamicum NCIMB 10025 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NADP+ - Corynebacterium glutamicum NCIMB 10025 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Escherichia coli L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H kinetic mechanism Escherichia coli L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-aspartate 4-semialdehyde + NADPH - Escherichia coli L-homoserine + NADP+ - r 371007 1.1.1.3 L-aspartate 4-semialdehyde + NADPH part of the aspartate pathway of amino acid biosynthesis Escherichia coli L-homoserine + NADP+ - r 371007 1.1.1.3 L-homoserine + NAD(P)+ - Escherichia coli L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-homoserine + NAD+ - Escherichia coli L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 additional information the bifunctional enzyme also exhibits aspartokinase activity, EC 2.7.2.4 Escherichia coli ? - - 89 1.1.1.3 L-homoserine + NAD+ - Escherichia coli W3110 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 additional information the bifunctional enzyme also exhibits aspartokinase activity, EC 2.7.2.4 Escherichia coli W3110 ? - - 89 1.1.1.3 L-aspartate 4-semialdehyde + NADH - Glycine max L-homoserine + NAD+ - r 414755 1.1.1.3 L-aspartate 4-semialdehyde + NADPH - Glycine max L-homoserine + NADP+ - r 371007 1.1.1.3 L-homoserine + NAD+ - Glycine max L-aspartate 4-semialdehyde + NADH - r 414770 1.1.1.3 L-homoserine + NADP+ - Glycine max L-aspartate 4-semialdehyde + NADPH - r 371012 1.1.1.3 additional information enzyme does not show aspartate kinase activity Glycine max ? - ? 89 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Hordeum vulgare L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H third reaction in the pathway between aspartate and the amino acids threonine, isoleucine, methionine Hordeum vulgare L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-homoserine + NAD(P)+ - Hordeum vulgare L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-aspartate 4-semialdehyde + NADPH + H+ - Lactiplantibacillus plantarum L-homoserine + NADP+ - ? 384984 1.1.1.3 L-aspartate 4-semialdehyde + NADPH + H+ - Lactiplantibacillus plantarum NCIMB 8826 L-homoserine + NADP+ - ? 384984 1.1.1.3 L-homoserine + NADP+ - Mycobacterium leprae L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NADP+ - Mycobacterium leprae TN L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NAD+ - Paracoccidioides brasiliensis L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NAD+ - Paracoccidioides brasiliensis L-aspartate 4-semialdehyde + NADH + H+ - r 438378 1.1.1.3 L-homoserine + NAD+ - Paracoccidioides brasiliensis PB18 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NAD+ - Paracoccidioides brasiliensis PB18 L-aspartate 4-semialdehyde + NADH + H+ - r 438378 1.1.1.3 L-homoserine + NAD+ - Paracoccidioides lutzii L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NAD+ - Paracoccidioides lutzii Pb01 L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Pisum sativum L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H third reaction in the pathway between aspartate and the amino acids threonine, isoleucine, methionine Pisum sativum L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-aspartate 4-semialdehyde + NADH + H+ - Pisum sativum L-homoserine + NAD+ - r 451032 1.1.1.3 L-homoserine + NAD(P)+ - Pisum sativum L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-homoserine + NAD+ - Pyrococcus horikoshii L-aspartate 4-semialdehyde + NADH + H+ - r 438378 1.1.1.3 L-homoserine + NADP+ no activity of the wild-type enzyme with NADP+, but only with enzyme mutants R40A and K57A Pyrococcus horikoshii L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NAD+ - Pyrococcus horikoshii ATCC 700860 L-aspartate 4-semialdehyde + NADH + H+ - r 438378 1.1.1.3 L-homoserine + NADP+ no activity of the wild-type enzyme with NADP+, but only with enzyme mutants R40A and K57A Pyrococcus horikoshii ATCC 700860 L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Ricinus communis L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-homoserine + NAD(P)+ - Ricinus communis L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Saccharomyces cerevisiae L-homoserine + NAD(P)+ - ? 165091 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Saccharomyces cerevisiae L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H kinetic mechanism Saccharomyces cerevisiae L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H essential step in amino acids L-methionine, L-threonine, and L-isoleucine biosynthesis Saccharomyces cerevisiae L-homoserine + NAD(P)+ - ? 165091 1.1.1.3 L-homoserine + NAD(P)+ - Saccharomyces cerevisiae L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-homoserine + NADP+ - Saccharomyces cerevisiae L-aspartate 4-semialdehyde + NADPH - ? 371012 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Serratia marcescens L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-homoserine + NAD(P)+ - Serratia marcescens L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 DL-aspartate 4-semialdehyde + NADPH + H+ - Spinacia oleracea L-homoserine + NADP+ - r 451031 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Spinacia oleracea L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-homoserine + NAD(P)+ - Spinacia oleracea L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-homoserine + NADP+ - Staphylococcus aureus L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NADP+ - Staphylococcus aureus COL L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NAD(P)+ - Streptomyces clavuligerus L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-homoserine + NAD(P)+ - Streptomyces clavuligerus NRRL 3585 L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-homoserine + NAD(P)+ - Sulfurisphaera tokodaii L-aspartate 4-semialdehyde + NAD(P)H + H+ - r 438377 1.1.1.3 L-homoserine + NAD+ - Sulfurisphaera tokodaii L-aspartate 4-semialdehyde + NADH + H+ - r 438378 1.1.1.3 L-homoserine + NADP+ - Sulfurisphaera tokodaii L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NAD+ - Sulfurisphaera tokodaii DSM 16993 L-aspartate 4-semialdehyde + NADH + H+ - r 438378 1.1.1.3 L-homoserine + NADP+ - Sulfurisphaera tokodaii DSM 16993 L-aspartate 4-semialdehyde + NADPH + H+ - r 438379 1.1.1.3 L-homoserine + NAD(P)+ - Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7 L-aspartate 4-semialdehyde + NAD(P)H + H+ - r 438377 1.1.1.3 L-homoserine + NAD+ - Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7 L-aspartate 4-semialdehyde + NADH + H+ - r 438378 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Thermophilic bacterium L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-homoserine + NAD(P)+ - Thermophilic bacterium L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-homoserine + NADP+ - Thermotoga maritima L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 additional information the bifunctional enzyme also exhibits aspartokinase (AK) activity, EC 2.7.2.4. It shows substantial activities of both AK and homoserine dehydrogenase (HseDH) Thermotoga maritima ? - - 89 1.1.1.3 L-homoserine + NADP+ - Thermotoga maritima ATCC 43589 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 additional information the bifunctional enzyme also exhibits aspartokinase (AK) activity, EC 2.7.2.4. It shows substantial activities of both AK and homoserine dehydrogenase (HseDH) Thermotoga maritima ATCC 43589 ? - - 89 1.1.1.3 L-homoserine + NADP+ - Thermotoga maritima DSM 3109 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 additional information the bifunctional enzyme also exhibits aspartokinase (AK) activity, EC 2.7.2.4. It shows substantial activities of both AK and homoserine dehydrogenase (HseDH) Thermotoga maritima DSM 3109 ? - - 89 1.1.1.3 L-homoserine + NADP+ - Thermotoga maritima JCM 10099 L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 additional information the bifunctional enzyme also exhibits aspartokinase (AK) activity, EC 2.7.2.4. It shows substantial activities of both AK and homoserine dehydrogenase (HseDH) Thermotoga maritima JCM 10099 ? - - 89 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Thermus thermophilus L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-homoserine + NAD(P)+ - Thermus thermophilus L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-homoserine + NAD+ - Thermus thermophilus L-aspartate 4-semialdehyde + NADH + H+ - ? 438378 1.1.1.3 L-homoserine + NADP+ - Thermus thermophilus L-aspartate 4-semialdehyde + NADPH + H+ - ? 438379 1.1.1.3 additional information substrates binding modes, overview Thermus thermophilus ? - - 89 1.1.1.3 L-aspartate 4-semialdehyde + NAD(P)H - Triticum aestivum L-homoserine + NAD(P)+ - r 165091 1.1.1.3 L-homoserine + NAD(P)+ - Triticum aestivum L-aspartate 4-semialdehyde + NAD(P)H - r 165090 1.1.1.3 L-aspartate 4-semialdehyde + NADPH + H+ - Zea mays L-homoserine + NADP+ - r 384984