1.1.1.23 L-histidinal + NAD+ + H2O - Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+ - ir 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Asparagus officinalis L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Bacillus subtilis L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Escherichia coli L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Bos taurus L-histidine + NADH + H+ - ir 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Triticum aestivum L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Geobacillus stearothermophilus L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Cucumis sativus L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Lactuca sativa L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - [Bacillus] caldolyticus L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Brassica oleracea L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Solanum melongena L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Rosa sp. L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Sporosarcina psychrophila L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Brassica oleracea var. capitata L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Paenarthrobacter histidinolovorans L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + NADH + H+ - ir 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Asparagus officinalis L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Bacillus subtilis L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Escherichia coli L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Triticum aestivum L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Geobacillus stearothermophilus L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Cucumis sativus L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Lactuca sativa L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate [Bacillus] caldolyticus L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Brassica oleracea L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Solanum melongena L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Rosa sp. L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Sporosarcina psychrophila L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Brassica oleracea var. capitata L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Paenarthrobacter histidinolovorans L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal Bos taurus L-histidine + NADH + H+ - ir 187855 1.1.1.23 L-histidinal + NAD+ + H2O - Bacillus subtilis HT1 L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinal + NAD+ + H2O reaction intermediate Bacillus subtilis HT1 L-histidine + NADH + H+ - ? 187855 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + 2 NADH + 2 H+ - ir 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Asparagus officinalis L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Bacillus subtilis L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Escherichia coli L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Triticum aestivum L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Geobacillus stearothermophilus L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Cucumis sativus L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Lactuca sativa L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - [Bacillus] caldolyticus L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Brassica oleracea L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Solanum melongena L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Rosa sp. L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Sporosarcina psychrophila L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Brassica oleracea var. capitata L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Paenarthrobacter histidinolovorans L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O part of L-histidine biosynthesis Escherichia coli L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Bacillus subtilis HT1 L-histidine + 2 NADH + 2 H+ - ? 187854 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Brucella sp. L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Brucella suis L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Escherichia coli L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Brucella suis bv. 1 L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Geotrichum candidum L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Mycobacterium tuberculosis L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Burkholderia pseudomallei L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Brassica oleracea L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O via L-histidinaldehyde intermediate Mycobacterium tuberculosis L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O the enzyme is highly specific for histidinol and NAD+ Escherichia coli L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O NAD+- and Zn+-dependent conversion of L-histidinol to L-histidine through an L-histidinaldehyde intermediate, leading to the concomitant reduction of 2 NAD+ molecules Mycobacterium tuberculosis L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O the enzyme is highly specific for histidinol and NAD+ Salmonella enterica subsp. enterica serovar Typhimurium L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O two steps: NAD+-dependent oxidations of L-histidinol to L-histidinaldehyde and subsequently to L-histidine Brucella suis bv. 1 L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Brucella suis 1330 L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Mycobacterium tuberculosis H37Rv L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O NAD+- and Zn+-dependent conversion of L-histidinol to L-histidine through an L-histidinaldehyde intermediate, leading to the concomitant reduction of 2 NAD+ molecules Mycobacterium tuberculosis H37Rv L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O via L-histidinaldehyde intermediate Mycobacterium tuberculosis H37Rv L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Burkholderia pseudomallei K96243 L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O - Brucella suis bv. 1 1330 L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + 2 NAD+ + H2O two steps: NAD+-dependent oxidations of L-histidinol to L-histidinaldehyde and subsequently to L-histidine Brucella suis bv. 1 1330 L-histidine + 2 NADH + 3 H+ - ? 421994 1.1.1.23 L-histidinol + NAD+ - Bos taurus L-histidinal + NADH + H+ - ir 371011 1.1.1.23 L-histidinol + NAD+ - Escherichia coli L-histidinal + NADH + H+ - ir 371011 1.1.1.23 L-histidinol + NAD+ enzyme is responsible for catalysis of the terminal step in L-histidine biosynthesis, being performed in 2 sequential reactions via the intermediate L-histidinal Bos taurus L-histidinal + NADH + H+ - ir 371011 1.1.1.23 additional information ligand-protein interactions in the active site of GcHDH, molecular docking, overview Geotrichum candidum ? - ? 89 1.1.1.23 additional information active site binding structure for substrates L-histidinol, L-histamine, and L-histidine, NMR study Escherichia coli ? - ? 89 1.1.1.23 additional information imidazole-containing substrate analogues are likely to bind to free enzyme Mycobacterium tuberculosis ? - ? 89 1.1.1.23 additional information imidazole-containing substrate analogues are likely to bind to free enzyme Mycobacterium tuberculosis H37Rv ? - ? 89