1.1.1.205 5'-amino-5'-deoxyinosine 5'-N-phosphate + NAD+ + H2O - Klebsiella aerogenes 5'-amino-5'-deoxyxanthosine 5'-N-phosphate + NADH - ? 230586 1.1.1.205 5'-mercapto-5'-deoxyinosine 5'-S-phosphate + NAD+ + H2O - Klebsiella aerogenes 5'-mercapto-5'-deoxyxanthosine 5'-phosphate + NADH - ? 230585 1.1.1.205 6-thio-IMP + NAD+ + H2O - Klebsiella aerogenes 6-thio-XMP + NADH + H+ - r 451001 1.1.1.205 6-thioinosine 5'-phosphate + NAD+ + H2O - Klebsiella aerogenes 6-thioxanthosine 5'-phosphate + NADH - ? 230583 1.1.1.205 IMP + APAD+ + H2O - Mycobacterium tuberculosis XMP + APADH + H+ - ? 439615 1.1.1.205 IMP + APAD+ + H2O - Mycobacterium tuberculosis H37Rv XMP + APADH + H+ - ? 439615 1.1.1.205 IMP + beta-NAD+ + H2O - Homo sapiens XMP + beta-NADH + H+ - ? 439616 1.1.1.205 IMP + NAD+ - Homo sapiens XMP + NADH + H+ - ? 438361 1.1.1.205 IMP + NAD+ + H2O - Homo sapiens XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Sus scrofa XMP + NADH + H+ - r 421987 1.1.1.205 IMP + NAD+ + H2O - Aspergillus nidulans XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Cryptosporidium parvum XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Halobacterium salinarum XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Klebsiella pneumoniae XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Mycobacterium tuberculosis XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Helicobacter pylori XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Clostridium perfringens XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Pneumocystis carinii XMP + NADH + H+ - r 421987 1.1.1.205 IMP + NAD+ + H2O - Vibrio cholerae serotype O1 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Bacillus thuringiensis XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Acinetobacter baumannii XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Campylobacter jejuni XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Penicillium brevicompactum XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Bacillus anthracis XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Eremothecium gossypii XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Homo sapiens XMP + NADH + H+ - r 421987 1.1.1.205 IMP + NAD+ + H2O - Pyrococcus furiosus XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Tritrichomonas foetus XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Pseudomonas aeruginosa XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Mirounga angustirostris XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Legionella pneumophila subsp. pneumophila XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Neisseria meningitidis XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Staphylococcus aureus XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Trypanosoma brucei brucei XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Bacillus amyloliquefaciens XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Streptococcus suis XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Leishmania amazonensis XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Sus scrofa XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Burkholderia thailandensis XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Lontra longicaudis annectens XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Mycolicibacterium thermoresistibile XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Vibrio cholerae XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Listeria monocytogenes XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Mus musculus XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides Halobacterium salinarum XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Bacillus anthracis Ames XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Staphylococcus aureus N315 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Mycolicibacterium thermoresistibile ATCC 19527 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Listeria monocytogenes ATCC BAA-679 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Bacillus thuringiensis BGSC 4AJ1 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Streptococcus suis ZY05719 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Legionella pneumophila subsp. pneumophila Philadelphia 1 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Halobacterium salinarum NRC 34002 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O rate-limiting enzyme in the de novo purine biosynthetic pathway leading to the formation of guanine ribonucleotides Halobacterium salinarum NRC 34002 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Mycobacterium tuberculosis H37Rv XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Acinetobacter baumannii 5377 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Klebsiella pneumoniae 52145 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Cryptosporidium parvum Iowa II XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Eremothecium gossypii ATCC 10895 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Vibrio cholerae ATCC 39315 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + NAD+ + H2O - Bacillus amyloliquefaciens TA208 XMP + NADH + H+ - ? 421987 1.1.1.205 IMP + thiazole-4-carboxamide adenine dinucleotide + H2O - Escherichia coli XMP + reduced thiazole-4-carboxamide adenine dinucleotide + H+ - r 451000 1.1.1.205 inosine + NAD+ + H2O 8% of the rate with inosine 5'-phosphate Pisum sativum xanthosine + NADH - ? 230587 1.1.1.205 inosine 5'-diphosphate + NAD+ + H2O - Bacillus cereus xanthosine 5'-diphosphate + NADH - ? 230588 1.1.1.205 inosine 5'-diphosphate + NAD+ + H2O - Campylobacter jejuni xanthosine 5'-diphosphate + NADH + H+ - ? 424837 1.1.1.205 inosine 5'-diphosphate + NAD+ + H2O - Cryptosporidium parvum xanthosine 5'-diphosphate + NADH + H+ - ? 424837 1.1.1.205 inosine 5'-diphosphate + NAD+ + H2O - Bacillus anthracis xanthosine 5'-diphosphate + NADH + H+ - ? 424837 1.1.1.205 inosine 5'-diphosphate + NAD+ + H2O - Babesia gibsoni xanthosine 5'-diphosphate + NADH + H+ - ? 424837 1.1.1.205 inosine 5'-diphosphate + NAD+ + H2O - Trypanosoma brucei xanthosine 5'-diphosphate + NADH + H+ xanthosine 5'-diphosphate is the only product ? 424837 1.1.1.205 inosine 5'-phosphate + 3-acetylpyridine adenine dinucleotide + H2O - Cryptosporidium parvum xanthosine 5'-phosphate + reduced 3-acetylpyridine adenine dinucleotide - ? 426511 1.1.1.205 inosine 5'-phosphate + acetylpyridine adenine dinucleotide + H2O - Homo sapiens xanthosine 5'-phosphate + reduced acetylpyridine adenine dinucleotide - ? 409594 1.1.1.205 inosine 5'-phosphate + acetylpyridine adenine dinucleotide + H2O - Cryptosporidium parvum xanthosine 5'-phosphate + reduced acetylpyridine adenine dinucleotide - ? 409594 1.1.1.205 inosine 5'-phosphate + NAD+ - Escherichia coli xanthosine 5'-phosphate + NADH + H+ - ? 409596 1.1.1.205 inosine 5'-phosphate + NAD+ - Mycobacterium tuberculosis xanthosine 5'-phosphate + NADH + H+ - ? 409596 1.1.1.205 inosine 5'-phosphate + NAD+ - Tritrichomonas suis xanthosine 5'-phosphate + NADH + H+ - ? 409596 1.1.1.205 inosine 5'-phosphate + NAD+ - Homo sapiens xanthosine 5'-phosphate + NADH + H+ - ? 409596 1.1.1.205 inosine 5'-phosphate + NAD+ - Mus musculus xanthosine 5'-phosphate + NADH + H+ - ? 409596 1.1.1.205 inosine 5'-phosphate + NAD+ - Mycobacterium tuberculosis H37Rv xanthosine 5'-phosphate + NADH + H+ - ? 409596 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH - ir 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Gallus gallus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Cricetulus griseus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Bacillus subtilis xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Mus musculus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Mus musculus xanthosine 5'-phosphate + NADH - ir 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Escherichia coli xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Escherichia coli xanthosine 5'-phosphate + NADH - ir 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Homo sapiens xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Homo sapiens xanthosine 5'-phosphate + NADH - ir 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Homo sapiens xanthosine 5'-phosphate + NADH - r 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Rattus norvegicus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Pisum sativum xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Klebsiella aerogenes xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Klebsiella aerogenes xanthosine 5'-phosphate + NADH - ir 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Bacillus cereus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Schizosaccharomyces pombe xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Leishmania donovani xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Vaccinia virus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Chlorocebus aethiops xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Vigna unguiculata xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Eimeria tenella xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Tritrichomonas suis xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Tritrichomonas suis xanthosine 5'-phosphate + NADH - r 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Borreliella burgdorferi xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Toxoplasma gondii xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Parainfluenza virus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Candida albicans xanthosine 5'-phosphate + NADH - r 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O enzyme linked to proliferation and malignancy Rattus norvegicus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O obligatory step in biosynthesis of nucleic acid guanine Klebsiella aerogenes xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O subdomain of the enzyme is not required for catalytic activity Borreliella burgdorferi xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O IMP oxidation is the predominant metabolic route leading to ureide synthesis Vigna unguiculata xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis Escherichia coli xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis Homo sapiens xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis Homo sapiens xanthosine 5'-phosphate + NADH - ir 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis Rattus norvegicus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis Tritrichomonas suis xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Vaccinia virus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Parainfluenza virus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O the enzyme is important for the synthesis of guanine nucleotides Cricetulus griseus xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O the enzyme performs the rate-limiting step in guanine nucleotide biosynthesis Homo sapiens xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O the reaction is irreversible over the range of pH 5.5 to pH 8.8, step in guanylic acid biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH - ir 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O the reaction is irreversible over the range of pH 5.5 to pH 8.8 Salmonella enterica subsp. enterica serovar Typhimurium xanthosine 5'-phosphate + NADH - ir 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O enzyme is highly specific for both inosine 5'-phosphate and NAD+ Leishmania donovani xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Vaccinia virus Elstree xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Vaccinia virus Elstree xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Bacillus subtilis M xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Bacillus subtilis NA7821 xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Candida albicans CAI-4 xanthosine 5'-phosphate + NADH - r 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Leishmania donovani MPA100 xanthosine 5'-phosphate + NADH - ? 230582 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Cricetulus griseus xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Staphylococcus aureus xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Mus musculus xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Escherichia coli xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Homo sapiens xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Rattus norvegicus xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Cryptosporidium parvum xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Klebsiella aerogenes xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Streptococcus pyogenes xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Mycobacterium tuberculosis xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Leishmania donovani xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Candida albicans xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Plasmodium falciparum xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Eimeria tenella xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Thermotoga maritima xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Pyrococcus horikoshii xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Tritrichomonas suis xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Borreliella burgdorferi xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Pyrococcus horikoshii OT3 xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Streptococcus suis xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Trypanosoma brucei xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Pneumocystis carinii xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O IMPDH catalyzes a dehydrogenase reaction and a hydrolysis reaction, a redox step producing NADH and the covalent intermediate E-xanthosine 5'-monophosphate and a hydrolysis step that produces xanthosine 5'-monophosphate. The enzyme toggles between the open conformation required for the dehydrogenase reaction and the closed conformation of the hydrolase reaction by moving a mobile flap into the NAD site. The dehydrogenase and hydrolase reactions display significant differences in the host (Homo sapiens) and parasite (Cryptosporidium parvum) enzymes, in keeping with the phylogenetic and structural divergence of their active sites Cryptosporidium parvum xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O IMPDH catalyzes a dehydrogenase reaction and a hydrolysis reaction, a redox step producing NADH and the covalent intermediate E-xanthosine 5'-monophosphate* and a hydrolysis step that produces xanthosine 5'-monophosphate. The enzyme toggles between the open conformation required for the dehydrogenase reaction and the closed conformation of the hydrolase reaction by moving a mobile flap into the NAD site. The dehydrogenase and hydrolase reactions display significant differences in the host (Homo sapiens) and parasite (Cryptosporidium parvum) enzymes, in keeping with the phylogenetic and structural divergence of their active sites Homo sapiens xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphate + NAD+ + H2O - Streptococcus suis 2 xanthosine 5'-phosphate + NADH + H+ - ? 409595 1.1.1.205 inosine 5'-phosphorothioate + NAD+ + H2O - Klebsiella aerogenes xanthosine 5'-phosphorothioate + NADH - ? 230584 1.1.1.205 inosine 5'-triphosphate + NAD+ + H2O - Bacillus cereus xanthosine 5'-triphosphate + NADH - ? 230589 1.1.1.205 additional information enzyme inhibition by mycophenolic acid impairs maturation and function of dendritic cells due to low GTP levels and reduced expression of CD80, CD40, CD86, CD54, and CD83 in dendritic cells, accompanied by a decreased capacity to stimulate T-lymphocytes Homo sapiens ? - ? 89 1.1.1.205 additional information enzyme mutations are involved in autosomal dominant retinitis pigmentosa, pathological mechanism, overview Homo sapiens ? - ? 89 1.1.1.205 additional information increased activities of IMP DH and GMP synthase and in the elevated concentrations of guanylates in hepatomas and other tumor cells Homo sapiens ? - ? 89 1.1.1.205 additional information increased activities of IMP DH and GMP synthase and in the elevated concentrations of guanylates in hepatomas and other tumor cells Rattus norvegicus ? - ? 89 1.1.1.205 additional information inhibition of the enzyme in K562 cells sensitizes the before resistant cells to methotrexate Homo sapiens ? - ? 89 1.1.1.205 additional information isozyme IMPDH-1 is essential for T lymphocyte development, enzyme inhibitor mycophenolic acid inhibits tumor-associated angiogenesis Homo sapiens ? - ? 89 1.1.1.205 additional information the enzyme is rate-limiting in the de novo synthesis of guanine nucleotides Homo sapiens ? - ? 89 1.1.1.205 additional information the parasite damages fetuses in utero and threatens immunocompromized individuals Toxoplasma gondii ? - ? 89 1.1.1.205 additional information ssDNA and RNA binding of wild-type and mutant IMPDH1s Homo sapiens ? - ? 89 1.1.1.205 additional information the enzyme binds both RNA and DNA in vitro and in vivo Escherichia coli ? - ? 89 1.1.1.205 additional information the enzyme binds both RNA and DNA in vitro and in vivo Homo sapiens ? - ? 89 1.1.1.205 additional information the enzyme binds both RNA and DNA in vitro and in vivo Tritrichomonas suis ? - ? 89 1.1.1.205 additional information the enzyme interacts with GTP which leads to formation of linear arrays, GTP reverses the enzyme aggregation by inhibitor mycophenolic acid Homo sapiens ? - ? 89 1.1.1.205 additional information the CBS subdomain of IMPDH coordinately regulates the adenine and guanine nucleotide pool Escherichia coli ? - ? 89 1.1.1.205 additional information assay method optimization. XMP detection and quantification by anion exchange chromatography Homo sapiens ? - ? 89 1.1.1.205 additional information IMP- and XMP-enzyme binding structure analysis, overview Vibrio cholerae serotype O1 ? - ? 89 1.1.1.205 additional information IMP-enzyme binding structure analysis, overview Clostridium perfringens ? - ? 89 1.1.1.205 additional information IMP-enzyme binding structure analysis, overview Campylobacter jejuni ? - ? 89 1.1.1.205 additional information IMP-enzyme binding structure analysis, overview Bacillus anthracis ? - ? 89 1.1.1.205 additional information the enzyme does not hydrolyze oxanosine monophosphate Cryptosporidium parvum ? - - 89 1.1.1.205 additional information the enzyme does not hydrolyze oxanosine monophosphate Homo sapiens ? - - 89 1.1.1.205 additional information the enzyme does not hydrolyze oxanosine monophosphate Tritrichomonas foetus ? - - 89 1.1.1.205 additional information the enzyme does not hydrolyze oxanosine monophosphate Bacillus anthracis ? - - 89 1.1.1.205 additional information the enzyme does not hydrolyze oxanosine monophosphate Campylobacter jejuni ? - - 89