1.1.1.218 1-indanol + NADP+ - Oryctolagus cuniculus 1-indanone + NADPH - ? 187821 1.1.1.218 3-hydroxyhexobarbital + NADP+ does not serve as a substrate for guinea pig enzyme Oryctolagus cuniculus ? - ? 187820 1.1.1.218 benzenedihydrodiol + NADP+ - Oryctolagus cuniculus ? - ? 187823 1.1.1.218 codeine + NAD(P)+ - Pseudomonas putida codeinone + NAD(P)H - ? 187813 1.1.1.218 codeine + NAD(P)+ codeine best substrate Oryctolagus cuniculus codeinone + NAD(P)H - ? 187813 1.1.1.218 codeine + NAD(P)+ only weak enzyme activity for codeine Mesocricetus auratus codeinone + NAD(P)H - ? 187813 1.1.1.218 codeine + NAD(P)+ oxidation at 80% the rate of morphine oxidation Cavia porcellus codeinone + NAD(P)H - ? 187813 1.1.1.218 codeine + NAD(P)+ - Pseudomonas putida M10 codeinone + NAD(P)H - ? 187813 1.1.1.218 codeine + NAD(P)+ oxidation at 80% the rate of morphine oxidation Cavia porcellus Hartley codeinone + NAD(P)H - ? 187813 1.1.1.218 codeine + NADP+ codeine as the sole carbon and energy source Pseudomonas putida codeinone + NADPH - ? 369960 1.1.1.218 codeine + NADP+ codeine as the sole carbon and energy source Pseudomonas putida M10 codeinone + NADPH - ? 369960 1.1.1.218 cyclohexene-2-ol + NADP+ - Oryctolagus cuniculus cyclohexene-2-one + NADPH - ? 187822 1.1.1.218 dihydrocodeine + NADP+ - Cavia porcellus dihydrocodeinone + NADPH - ? 187814 1.1.1.218 dihydrocodeine + NADP+ - Oryctolagus cuniculus dihydrocodeinone + NADPH - ? 187814 1.1.1.218 dihydrocodeine + NADP+ - Pseudomonas putida dihydrocodeinone + NADPH - ? 187814 1.1.1.218 dihydrocodeine + NADP+ - Pseudomonas putida M10 dihydrocodeinone + NADPH - ? 187814 1.1.1.218 dihydrocodeine + NADP+ - Cavia porcellus Hartley dihydrocodeinone + NADPH - ? 187814 1.1.1.218 ethylmorphine + NAD(P)+ - Oryctolagus cuniculus ? - ? 187817 1.1.1.218 ethylmorphine + NAD(P)+ oxidation at 51% the rate of morphine oxidation Cavia porcellus ? - ? 187817 1.1.1.218 additional information the enzyme AKR1C34 shows 3alpha/17beta/20alpha-hydroxysteroid dehydrogenase activities, EC 1.1.1.239, detailed overview. Ala54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS) Mesocricetus auratus ? - ? 89 1.1.1.218 additional information the enzyme shows NAD+-dependent dehydrogenase activity towards other nonsteroidal alicyclic alcohols and 3alpha/17beta-hydroxy-C18/C19/C21-steroids, detailed overview Oryctolagus cuniculus ? - ? 89 1.1.1.218 morphine + NAD(P)+ - Homo sapiens morphinone + NAD(P)H - ir 385199 1.1.1.218 morphine + NAD+ - Mesocricetus auratus ? - ? 438398 1.1.1.218 morphine + NAD+ - Oryctolagus cuniculus morphinone + NADH + H+ - ? 438399 1.1.1.218 morphine + NADP+ - Cavia porcellus morphinone + NADPH + H+ - ? 187812 1.1.1.218 morphine + NADP+ enzyme activity only with NAD+ Mesocricetus auratus morphinone + NADPH + H+ - ? 187812 1.1.1.218 morphine + NADP+ + NAD+: enzyme activity ten times that with NADP+ Rattus norvegicus morphinone + NADPH + H+ - ? 187812 1.1.1.218 morphine + NADP+ enzyme activity only with NADP+ Pseudomonas putida morphinone + NADPH + H+ - ? 187812 1.1.1.218 morphine + NADP+ enzyme acitivity with NAD+ four times that with NADP+ Oryctolagus cuniculus morphinone + NADPH + H+ - ? 187812 1.1.1.218 morphine + NADP+ enzyme activity only with NADP+ Pseudomonas putida M10 morphinone + NADPH + H+ - ? 187812 1.1.1.218 morphine + NADP+ + NAD+: enzyme activity ten times that with NADP+ Rattus norvegicus Wistar morphinone + NADPH + H+ - ? 187812 1.1.1.218 morphine + NADP+ - Cavia porcellus Hartley morphinone + NADPH + H+ - ? 187812 1.1.1.218 morphine + NADP+ highly specific alkaloid dehydrogenase, oxidizing only the C-6 hydroxy group of morphine and codeine, morphine as the sole carbon and energy source Pseudomonas putida morphinone + NADPH - ? 369959 1.1.1.218 morphine + NADP+ highly specific alkaloid dehydrogenase, oxidizing only the C-6 hydroxy group of morphine and codeine, morphine as the sole carbon and energy source Pseudomonas putida M10 morphinone + NADPH - ? 369959 1.1.1.218 nalorphine + NAD(P)+ best substrate, oxidation at 120% the rate of morphine oxidation Cavia porcellus (5alpha)-3-hydroxy-17-(prop-2-en-1-yl)-7,8-didehydro-4,5-epoxymorphinan-6-one + NAD(P)H + H+ - ? 187815 1.1.1.218 nalorphine + NAD(P)+ best substrate, oxidation at 120% the rate of morphine oxidation Cavia porcellus Hartley (5alpha)-3-hydroxy-17-(prop-2-en-1-yl)-7,8-didehydro-4,5-epoxymorphinan-6-one + NAD(P)H + H+ - ? 187815 1.1.1.218 naloxone + NADH + H+ - Cavia porcellus ? - r 451011 1.1.1.218 naloxone + NADH + H+ - Cavia porcellus Hartley ? - r 451011 1.1.1.218 normorphine + NAD(P)+ - Oryctolagus cuniculus ? - ? 187816 1.1.1.218 normorphine + NAD(P)+ best substrate, oxidation at 139% the rate of morphine oxidation Mesocricetus auratus ? - ? 187816 1.1.1.218 normorphine + NAD(P)+ about 3 times better substrate than morphine Cavia porcellus ? - ? 187816 1.1.1.218 normorphine + NAD(P)+ about 3 times better substrate than morphine Cavia porcellus Hartley ? - ? 187816 1.1.1.218 trans-1,4-decalindiol + NADP+ about 30% of the activity observed with morphine Cavia porcellus ? - ? 187819 1.1.1.218 trans-naphthalene dihydrodiol + NAD+ - Mesocricetus auratus ? - ? 439948 1.1.1.218 trans-naphthalene dihydrodiol + NAD+ - Oryctolagus cuniculus ? + NADH + H+ - ? 439949 1.1.1.218 codeine + NAD(P)+ oxidation at 120% the rate of morphine oxidation Pseudomonas putida codeinone + NAD(P)H at pH 6.5, + NADPH, reduction of codeinone to codeine r 187813 1.1.1.218 codeine + NAD(P)+ oxidation at 120% the rate of morphine oxidation Pseudomonas putida M10 codeinone + NAD(P)H at pH 6.5, + NADPH, reduction of codeinone to codeine r 187813 1.1.1.218 codeine + NAD(P)+ non-Theorell-Chance sequential ordered mechanism for codeine oxidation at pH 9.5 Pseudomonas putida codeinone + NAD(P)H morphine dehydrogenase follows a Theorell-Chance mechanism for codeinone reduction at pH 7.0 ? 187813 1.1.1.218 codeine + NAD(P)+ non-Theorell-Chance sequential ordered mechanism for codeine oxidation at pH 9.5 Pseudomonas putida M10 codeinone + NAD(P)H morphine dehydrogenase follows a Theorell-Chance mechanism for codeinone reduction at pH 7.0 ? 187813 1.1.1.218 morphine + NADP+ - Cavia porcellus morphinone + NADPH + H+ production of morphinone demonstrated in vitro experiments ? 187812 1.1.1.218 morphine + NADP+ - Cavia porcellus Hartley morphinone + NADPH + H+ production of morphinone demonstrated in vitro experiments ? 187812 1.1.1.218 naloxone + NAD(P)H - Cavia porcellus 6alpha-naloxol + NADP+ stereospecific reduction ? 187818 1.1.1.218 naloxone + NAD(P)H - Cavia porcellus Hartley 6alpha-naloxol + NADP+ stereospecific reduction ? 187818