1.1.1.215 additional information no activity on other sugars and sugar acids Pseudomonas plecoglossicida ? - - 89 1.1.1.215 additional information no activity on other sugars and sugar acids Pseudomonas plecoglossicida JUIM01 ? - - 89 1.1.1.215 2,5-diketo-D-gluconate + NADPH - Escherichia coli 5-keto-D-gluconate + NADP+ - ? 187809 1.1.1.215 2-dehydro-D-gluconate + NADPH - Escherichia coli D-gluconate + NADP+ - ? 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH - Penicillium chrysogenum D-gluconate + NADP+ - ? 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH - acetic acid bacteria D-gluconate + NADP+ - ? 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH - Brevibacterium ketosoreductum D-gluconate + NADP+ - ? 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH 11.8% of activity with 2,5-diketo-D-gluconate Brevibacterium ketosoreductum D-gluconate + NADP+ - ? 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH 2-keto-D-gluconate, part of non-phosphorylative pathway of carbohydrates predominantly in acetic acid bacteria acetic acid bacteria D-gluconate + NADP+ - ? 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH - Brevibacterium ketosoreductum ATCC 21914 D-gluconate + NADP+ - ? 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH 11.8% of activity with 2,5-diketo-D-gluconate Brevibacterium ketosoreductum ATCC 21914 D-gluconate + NADP+ - ? 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH - Penicillium chrysogenum Westling D-gluconate + NADP+ - ? 187797 1.1.1.215 2-keto-L-gluconic acid + NADH + H+ - Ketogulonicigenium vulgare L-idonate + NAD+ - ? 440664 1.1.1.215 2-keto-L-gluconic acid + NADH + H+ - Ketogulonicigenium vulgare Y25 L-idonate + NAD+ - ? 440664 1.1.1.215 2-keto-L-gluconic acid + NADPH + H+ - Ketogulonicigenium vulgare L-idonate + NADP+ - ? 440092 1.1.1.215 2-keto-L-gluconic acid + NADPH + H+ - Ketogulonicigenium vulgare Y25 L-idonate + NADP+ - ? 440092 1.1.1.215 2-keto-L-gulonate + NADPH - Escherichia coli L-idonate + NADP+ - ? 187801 1.1.1.215 2-keto-L-gulonate + NADPH 10.8% of activity with 2,5-diketo-D-gluconate Brevibacterium ketosoreductum L-idonate + NADP+ - ? 187801 1.1.1.215 2-keto-L-gulonate + NADPH 10.8% of activity with 2,5-diketo-D-gluconate Brevibacterium ketosoreductum ATCC 21914 L-idonate + NADP+ - ? 187801 1.1.1.215 2-oxo-D-gluconate + NADH + H+ enzyme shows dual cofactor specificity, being able to use both NADPH and NADH Gluconobacter oxydans D-gluconate + NAD+ - ? 425470 1.1.1.215 2-oxo-D-gluconate + NADH + H+ enzyme shows dual cofactor specificity, being able to use both NADPH and NADH Gluconobacter oxydans 621H D-gluconate + NAD+ - ? 425470 1.1.1.215 2-oxo-D-gluconate + NADPH + H+ - Gluconobacter oxydans D-gluconate + NADP+ - ? 424494 1.1.1.215 2-oxo-D-gluconate + NADPH + H+ enzyme shows dual cofactor specificity, being able to use both NADPH and NADH Gluconobacter oxydans D-gluconate + NADP+ - ? 424494 1.1.1.215 2-oxo-D-gluconate + NADPH + H+ - Gluconobacter oxydans 621H D-gluconate + NADP+ - ? 424494 1.1.1.215 2-oxo-D-gluconate + NADPH + H+ enzyme shows dual cofactor specificity, being able to use both NADPH and NADH Gluconobacter oxydans 621H D-gluconate + NADP+ - ? 424494 1.1.1.215 2-oxo-L-gulonate + NADPH + H+ - Gluconobacter oxydans L-idonate + NADP+ - ? 424495 1.1.1.215 2-oxo-L-gulonate + NADPH + H+ - Gluconobacter oxydans 621H L-idonate + NADP+ - ? 424495 1.1.1.215 5-keto-D-gluconate + NADPH - Gluconobacter oxydans D-gluconate + NADP+ - ? 187800 1.1.1.215 5-keto-D-gluconate + NADPH - Gluconacetobacter liquefaciens D-gluconate + NADP+ - ? 187800 1.1.1.215 5-keto-D-gluconate + NADPH poor substrate Acetobacter pasteurianus D-gluconate + NADP+ - ? 187800 1.1.1.215 5-keto-D-gluconate + NADPH poor substrate Acetobacter ascendens D-gluconate + NADP+ - ? 187800 1.1.1.215 acetaldehyde + NADPH + H+ poor substrate Acetobacter pasteurianus ethanol + NADP+ - ? 139551 1.1.1.215 D-gluconate + NADP+ - Gluconobacter frateurii 2-dehydro-D-gluconate + NADPH - ? 394817 1.1.1.215 D-gluconate + NADP+ - Gluconobacter oxydans 2-dehydro-D-gluconate + NADPH - ? 394817 1.1.1.215 D-gluconate + NADP+ the large subunit is the catalytically active enzyme part, high substrate and regiospecificity Gluconobacter frateurii 2-dehydro-D-gluconate + NADPH - ? 394817 1.1.1.215 D-gluconate + NADP+ - Gluconobacter oxydans 621H 2-dehydro-D-gluconate + NADPH - ? 394817 1.1.1.215 D-gluconate + NADP+ - Gluconobacter frateurii IFO 3271 2-dehydro-D-gluconate + NADPH - ? 394817 1.1.1.215 D-gluconate + NADP+ the large subunit is the catalytically active enzyme part, high substrate and regiospecificity Gluconobacter frateurii IFO 3271 2-dehydro-D-gluconate + NADPH - ? 394817 1.1.1.215 D-gluconate + NADP+ - Gluconobacter japonicus 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ - Gluconobacter oxydans 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ - Pseudomonas plecoglossicida 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ the ability of CHA0 to acidify its environment is largely determined by its ability to produce gluconic acid from glucose Pseudomonas fluorescens 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ wild-type exhibits gluconate-dependent respiration. Genes cj0414 and cj0415, orthologous to GADH, are co-transcribed. Campylobacter jejuni 81–176 does not use gluconate compounds as sole carbon sources. GADH plays a minor role in mouse colonization Campylobacter jejuni 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ - Gluconobacter oxydans 621H 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ wild-type exhibits gluconate-dependent respiration. Genes cj0414 and cj0415, orthologous to GADH, are co-transcribed. Campylobacter jejuni 81–176 does not use gluconate compounds as sole carbon sources. GADH plays a minor role in mouse colonization Campylobacter jejuni 81-176 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ - Pseudomonas plecoglossicida JUIM01 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ the ability of CHA0 to acidify its environment is largely determined by its ability to produce gluconic acid from glucose Pseudomonas fluorescens CHA0 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-gluconate + NADP+ - Gluconobacter japonicus NBRC3271 2-dehydro-D-gluconate + NADPH + H+ - ? 404816 1.1.1.215 D-xylonate + NADPH - Gluconobacter oxydans 2-keto-D-xylonate + NADP+ - ? 187802 1.1.1.215 D-xylonate + NADPH - Acetobacter pasteurianus 2-keto-D-xylonate + NADP+ - ? 187802 1.1.1.215 D-xylonate + NADPH - Gluconacetobacter liquefaciens 2-keto-D-xylonate + NADP+ - ? 187802 1.1.1.215 glyoxal + NADPH reduction at 33% the rate of 2-ketogluconate reduction Acetobacter pasteurianus ? - ? 187731 1.1.1.215 glyoxylate + NADPH reduction at 350% the rate of 2-ketogluconate reduction Acetobacter pasteurianus glycolate + NADP+ - ? 187805 1.1.1.215 hydroxypyruvate + NADPH reduction at 733% the rate of 2-keto-gluconate reduction Acetobacter pasteurianus 2,3-dihydroxypropanoate + NADP+ - ? 187804 1.1.1.215 L-idonate + NAD+ - Aspergillus niger 2-oxo-L-gulonate + NADH + H+ - ? 439667 1.1.1.215 L-idonate + NADP+ - Acetobacter pasteurianus 2-keto-L-idonate + NADPH - ? 187798 1.1.1.215 L-idonate + NADP+ - Acetobacter ascendens 2-keto-L-idonate + NADPH - ? 187798 1.1.1.215 L-idonate + NADP+ poor substrate Acetobacter pasteurianus 2-keto-L-idonate + NADPH - ? 187798 1.1.1.215 L-idonate + NADP+ poor substrate Acetobacter ascendens 2-keto-L-idonate + NADPH - ? 187798 1.1.1.215 L-idonate + NADP+ best substrate Gluconobacter oxydans 2-keto-L-idonate + NADPH - ? 187798 1.1.1.215 L-idonate + NADP+ best substrate Gluconacetobacter liquefaciens 2-keto-L-idonate + NADPH - ? 187798 1.1.1.215 additional information no substrates are: 6-phospho-D-gluconate, D-mannonate, D-arabonate Gluconobacter oxydans ? - ? 89 1.1.1.215 additional information no substrates are: 6-phospho-D-gluconate, D-mannonate, D-arabonate Acetobacter pasteurianus ? - ? 89 1.1.1.215 additional information no substrates are: 6-phospho-D-gluconate, D-mannonate, D-arabonate Gluconacetobacter liquefaciens ? - ? 89 1.1.1.215 additional information no substrates are: 6-phospho-D-gluconate, D-mannonate, D-arabonate Acetobacter ascendens ? - ? 89 1.1.1.215 additional information D-xylonate, D-glucose, D-fructose, L-sorbose, 5-keto-D-fructose, D-sorbitol, glycerol Acetobacter ascendens ? - ? 89 1.1.1.215 additional information for large-scale production of 2-dehydro-D-gluconate, the cells require for formation of 2-dehydro-D-gluconate from D-gluconate oxygen as the final acceptor of electrons formed during the oxidation ofD -gluconate Gluconobacter oxydans ? - ? 89 1.1.1.215 additional information for large-scale production of 2-dehydro-D-gluconate, the cells require for formation of 2-dehydro-D-gluconate from D-gluconate oxygen as the final acceptor of electrons formed during the oxidation ofD -gluconate Gluconobacter oxydans 621H ? - ? 89 1.1.1.215 pyruvate + NADPH + H+ reduction at 7% the rate of 2-ketogluconate reduction Acetobacter pasteurianus lactate + NADP+ - ? 187803 1.1.1.215 2,5-diketo-D-gluconate + NADPH - Brevibacterium ketosoreductum 5-keto-D-gluconate + NADP+ - ir 187809 1.1.1.215 2,5-diketo-D-gluconate + NADPH - Brevibacterium ketosoreductum ATCC 21914 5-keto-D-gluconate + NADP+ - ir 187809 1.1.1.215 2-dehydro-D-gluconate + NADPH - Acetobacter pasteurianus D-gluconate + NADP+ - r 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH i.e. 2-keto-D-gluconate, best substrate for Acetobacter ascendens and Gluconobacter Gluconobacter oxydans D-gluconate + NADP+ - r 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH i.e. 2-keto-D-gluconate, best substrate for Acetobacter ascendens and Gluconobacter Gluconacetobacter liquefaciens D-gluconate + NADP+ - r 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH i.e. 2-keto-D-gluconate, best substrate for Acetobacter ascendens and Gluconobacter Acetobacter ascendens D-gluconate + NADP+ - r 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH strongly preferred reaction of Acetobacter enzyme Acetobacter pasteurianus D-gluconate + NADP+ - r 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH strongly preferred reaction of Acetobacter enzyme Acetobacter ascendens D-gluconate + NADP+ - r 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH equal reaction rate of reduction of 2-ketogluconate and oxidation of gluconate with Gluconobacter enzyme Acetobacter ascendens D-gluconate + NADP+ - r 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH reverse reaction at the same rate by Gluconobacter enzyme Gluconobacter oxydans D-gluconate + NADP+ - r 187797 1.1.1.215 2-dehydro-D-gluconate + NADPH reverse reaction at the same rate by Gluconobacter enzyme Gluconacetobacter liquefaciens D-gluconate + NADP+ - r 187797 1.1.1.215 2-keto-L-gulonate + NADPH - Acetobacter pasteurianus L-idonate + NADP+ - r 187801 1.1.1.215 2-keto-L-gulonate + NADPH - Acetobacter ascendens L-idonate + NADP+ - r 187801 1.1.1.215 2-keto-L-gulonate + NADPH third best substrate Gluconobacter oxydans L-idonate + NADP+ - r 187801 1.1.1.215 2-keto-L-gulonate + NADPH third best substrate Gluconacetobacter liquefaciens L-idonate + NADP+ - r 187801 1.1.1.215 2-keto-L-gulonate + NADPH third best substrate Acetobacter ascendens L-idonate + NADP+ - r 187801 1.1.1.215 2-keto-L-gulonate + NADPH betst substrate Acetobacter pasteurianus L-idonate + NADP+ - r 187801 1.1.1.215 2-oxo-L-gulonate + NADH + H+ - Aspergillus niger L-idonate + NAD+ - r 438741 1.1.1.215 2-oxo-L-gulonate + NADPH + H+ - Aspergillus niger L-idonate + NADP+ - r 424495 1.1.1.215 2-oxo-L-gulonate + NADPH + H+ - Aspergillus niger ATCC 1015 L-idonate + NADP+ - r 424495 1.1.1.215 2-oxo-L-gulonate + NADPH + H+ - Aspergillus niger CBS 113.46 L-idonate + NADP+ - r 424495 1.1.1.215 D-galactonate + NADP+ - Acetobacter pasteurianus 2-dehydro-D-galactonate + NADPH - r 187799 1.1.1.215 D-galactonate + NADP+ - Acetobacter ascendens 2-dehydro-D-galactonate + NADPH - r 187799 1.1.1.215 D-galactonate + NADP+ third best substrate Gluconobacter oxydans 2-dehydro-D-galactonate + NADPH - r 187799 1.1.1.215 D-galactonate + NADP+ third best substrate Gluconacetobacter liquefaciens 2-dehydro-D-galactonate + NADPH - r 187799 1.1.1.215 L-idonate + NADP+ - Aspergillus niger 2-oxo-L-gulonate + NADPH + H+ - r 459773 1.1.1.215 L-idonate + NADP+ - Aspergillus niger ATCC 1015 2-oxo-L-gulonate + NADPH + H+ - r 459773 1.1.1.215 L-idonate + NADP+ - Aspergillus niger CBS 113.46 2-oxo-L-gulonate + NADPH + H+ - r 459773