1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase hypothalamus in females, the level is the highest in the hypothalamus 740503 1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase hypothalamus in males, the highest transcript level is in telencephalon and hypothalamus 740503 1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) hypothalamus neurons 655138 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase hypothalamus - 673530 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase hypothalamus - 286475 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) hypothalamus - 389558, 389561, 656642 1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) hypothalamus cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity 389559 1.11.1.24 thioredoxin-dependent peroxiredoxin hypothalamus 0.0013 mg Prx I per mg of soluble protein Prx I, 0.0013 mg Prx II per mg of soluble protein, 0.0005 mg Prx III per mg of soluble protein, 0.0007 mg Prx V per mg of soluble protein and 0.0007 mg Prx VI per mg of soluble protein 655756 1.13.11.34 arachidonate 5-lipoxygenase hypothalamus - 439477 1.13.11.71 carotenoid-9',10'-cleaving dioxygenase hypothalamus - 745596 1.14.13.39 nitric-oxide synthase (NADPH) hypothalamus - 440224, 697042 1.14.13.39 nitric-oxide synthase (NADPH) hypothalamus estradiol regulates the nitrergic system in the supraoptic and paraventricular hypothalamic nuclei under acute osmotic stress conditions, but the effects specifically depend on the anatomical subregions and different estrogen receptors 743360 1.14.13.39 nitric-oxide synthase (NADPH) hypothalamus neurons of several nuclei of the hypothalamus, such as the arcuate nucleus (ARC) and paraventricular nucleus (PVN) -, 763849 1.14.14.14 aromatase hypothalamus AROM and NOS proteins are coexpressed with NADPH oxidase in the preoptic-anterior hypothalamus 764772 1.14.14.14 aromatase hypothalamus in the female, activity is detecable throughout the year 745062 1.14.14.18 heme oxygenase (biliverdin-producing) hypothalamus immortalized hypothalamic neurons GT1-7 689226 1.14.14.19 steroid 17alpha-monooxygenase hypothalamus - 715984, 727367 1.14.15.18 calcidiol 1-monooxygenase hypothalamus high enzyme level 659563 1.14.15.4 steroid 11beta-monooxygenase hypothalamus - 688009 1.14.16.2 tyrosine 3-monooxygenase hypothalamus - 658785, 659762, 673820, 687935, 745402 1.14.16.2 tyrosine 3-monooxygenase hypothalamus 2fold activity under cold stress. Injection of the angiotensin converting enzyme inhibitor enalapril malate prevented the increase of tyrosine hydroxylase under cold stress 672960 1.14.16.2 tyrosine 3-monooxygenase hypothalamus anterior and posterior 684367 1.14.16.2 tyrosine 3-monooxygenase hypothalamus in some cells of the hypothalamus, tyrosine hydroxylase is colocalized with vasoactive intestinal peptide 695603 1.14.16.2 tyrosine 3-monooxygenase hypothalamus posterior 689999 1.14.16.2 tyrosine 3-monooxygenase hypothalamus the enzyme content is reduced in the hypothalamic paraventricular nucleus, neurons and neuropil, of the seizure-sensitive gerbils 688723 1.14.16.4 tryptophan 5-monooxygenase hypothalamus - -, 687220, 689087, 727949 1.14.17.1 dopamine beta-monooxygenase hypothalamus - 438636, 727633, 744598 1.14.17.3 peptidylglycine monooxygenase hypothalamus - 438565, 697630 1.14.17.3 peptidylglycine monooxygenase hypothalamus 2 forms, distinguishable by molecular weight 438582 1.14.17.3 peptidylglycine monooxygenase hypothalamus PAM-1 and PAM-2 438587 1.14.99.1 prostaglandin-endoperoxide synthase hypothalamus fetal 686417 1.15.1.1 superoxide dismutase hypothalamus TCAP-1-responsive, immortalized N38 cells 685881 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) hypothalamus - 725082 1.21.99.4 thyroxine 5'-deiodinase hypothalamus - 697632 1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) hypothalamus - 389558, 389559, 389561, 390653, 390659, 390662 1.4.3.1 D-aspartate oxidase hypothalamus - 743140 1.4.3.1 D-aspartate oxidase hypothalamus in the cell bodies of the neurons 711719 1.4.3.3 D-amino-acid oxidase hypothalamus - 699164 1.4.3.4 monoamine oxidase hypothalamus MAO expression and activity are located in or adjacent to serotonergic nuclei and their targets especially in the ventral hypothalamus -, 705252 1.8.3.2 thiol oxidase hypothalamus high expression in neurons producing disulfide-bounded neuropeptides 659578 2.1.1.6 catechol O-methyltransferase hypothalamus - 685455 2.1.1.96 thioether S-methyltransferase hypothalamus - 676338 2.3.1.23 1-acylglycerophosphocholine O-acyltransferase hypothalamus - 755989 2.3.1.6 choline O-acetyltransferase hypothalamus afferent varicose fibers are immunopositive for ChAT in the ventral telencephalon, the preoptic area, the hypothalamus and the posterior tuberculum 756641 2.3.1.85 fatty-acid synthase system hypothalamus - 661661 2.3.2.5 glutaminyl-peptide cyclotransferase hypothalamus - 487990, 704085, 735738, 759702 2.4.1.92 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase hypothalamus - -, 736174 2.4.3.8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase hypothalamus - -, 736174, 764907 2.4.3.9 lactosylceramide alpha-2,3-sialyltransferase hypothalamus - -, 736174 2.5.1.16 spermidine synthase hypothalamus highest levels of expression in nucleus accumbens, taenia tecta, cerebellar cortex, cerebral cortical layer I, hippocampus, hypothalamus, mesencephalic raphe nuclei, central and lateral amygdala, and the circumventricular organs 688510 2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase hypothalamus - 672849, 675530 2.6.1.19 4-aminobutyrate-2-oxoglutarate transaminase hypothalamus enzyme activity of gamma-aminobutanoate transaminase is highest in the hypothalamus and optic textum 672849 2.6.1.42 branched-chain-amino-acid transaminase hypothalamus - 675509 2.6.1.64 glutamine-phenylpyruvate transaminase hypothalamus - -, 759850 2.7.1.1 hexokinase hypothalamus - 641072, 703290, 738756 2.7.1.1 hexokinase hypothalamus enzyme activities increase in the ventromedial hypothalamus as the glucose concentration rises. Enzyme activities in lateral hypothalamus decreases at 2.8 mM and 20 mM glucose 675095 2.7.1.1 hexokinase hypothalamus expression is altered by feeding conditions, especially in liver and hypothalamus where food deprivation decreases and refeeding increases expression. Activity in refed fish is higher than that of fed fish 671258 2.7.1.1 hexokinase hypothalamus the hypothalamus is the region of maximum activity (17.2%) 705268 2.7.1.105 6-phosphofructo-2-kinase hypothalamus - -, 738904 2.7.1.105 6-phosphofructo-2-kinase hypothalamus expressed at high abundance in both hypothalami and clonal hypothalamic neurons. In response to re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami 723032 2.7.1.137 phosphatidylinositol 3-kinase hypothalamus - -, 723027 2.7.1.151 inositol-polyphosphate multikinase hypothalamus - 723659 2.7.1.20 adenosine kinase hypothalamus - 661642 2.7.10.1 receptor protein-tyrosine kinase hypothalamus - 672851 2.7.11.1 non-specific serine/threonine protein kinase hypothalamus - -, 723027 2.7.11.11 cAMP-dependent protein kinase hypothalamus - 662681 2.7.11.12 cGMP-dependent protein kinase hypothalamus - 661531 2.7.11.12 cGMP-dependent protein kinase hypothalamus predominant expression of isozyme cGKIbeta 662962 2.7.11.13 protein kinase C hypothalamus - 662681 2.7.11.17 Ca2+/calmodulin-dependent protein kinase hypothalamus - 666110 2.7.11.2 [pyruvate dehydrogenase (acetyl-transferring)] kinase hypothalamus - 761984 2.7.11.25 mitogen-activated protein kinase kinase kinase hypothalamus - 762367 2.7.11.27 [acetyl-CoA carboxylase] kinase hypothalamus - 693951, 740990 2.7.11.27 [acetyl-CoA carboxylase] kinase hypothalamus determination of levels of hypothalamic phosphorylation of AMPK -, 741273 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase hypothalamus - 692267, 692682, 705267 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase hypothalamus dorso-mediobasal 705267 2.7.11.31 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase hypothalamus ventromedial hypothalamus 692000 2.7.12.2 mitogen-activated protein kinase kinase hypothalamus high expression level of MKK4 682214 2.7.12.2 mitogen-activated protein kinase kinase hypothalamus highest levels of expression 682214 3.1.1.3 triacylglycerol lipase hypothalamus - 709885 3.1.1.4 phospholipase A2 hypothalamus - 691482, 693770 3.1.1.7 acetylcholinesterase hypothalamus - 680122, 682110 3.1.3.108 nocturnin hypothalamus almost no changes of noc-b mRNAs are observed after a meal 755768 3.1.3.108 nocturnin hypothalamus high expression 755768 3.1.3.108 nocturnin hypothalamus moderate expression 755768 3.1.3.108 nocturnin hypothalamus noc-a mRNAs rise sharply after a meal 755768 3.1.3.16 protein-serine/threonine phosphatase hypothalamus in the supraoptic nucleus and the lateral preoptic area 655140 3.1.3.36 phosphoinositide 5-phosphatase hypothalamus highly expressed in neurons of the arcuate and lateral nuclei of the hypothalamus. Treatment with a phosphorthioate-modified antisense oligonucleotide for 5ptase IV reduces the hypothalamic expression of 5ptase IV by approximately 80% 679517 3.1.3.48 protein-tyrosine-phosphatase hypothalamus - 709938 3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase hypothalamus - 694494 3.1.3.B4 phosphatidylinositol-4-phosphate phosphatase hypothalamus high expression 751173 3.1.4.1 phosphodiesterase I hypothalamus highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus 682106 3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase hypothalamus - 716347 3.1.4.35 3',5'-cyclic-GMP phosphodiesterase hypothalamus - 716347 3.1.4.4 phospholipase D hypothalamus immunostaining weaker than in granule cell or vomeronasal nerve 681093 3.1.4.46 glycerophosphodiester phosphodiesterase hypothalamus - 679873 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase hypothalamus - 716347 3.1.4.54 N-acetylphosphatidylethanolamine-hydrolysing phospholipase D hypothalamus ventromedial nucleus. N-arachidonoylphosphatidylethanolamine phospholipase D is localized presynaptically and postsynaptically but shows a preferential distribution in dendrites. The dorsomedial region of the ventromedial nucleus of the hypothalamus displays the necessary machinery for the endocannabinoid-mediated modulation of synaptic transmission of brain circuitries that regulate important hypothalamic functions such as feeding behaviors 729811 3.3.2.10 soluble epoxide hydrolase hypothalamus - 661683 3.3.2.9 microsomal epoxide hydrolase hypothalamus - 663275