3.4.22.55 2008 cell - 732733 3.4.22.55 2008C13 cell - 732733 3.4.22.55 A-2780 cell - 732733 3.4.22.55 A-549 cell - 732068, 732733 3.4.22.55 A-549 cell expression of c-Myc and caspase-2 are crucial for cytochrome c release from mitochondria during cytotoxic stress. Caspase-2 is important for cytosolic Bax to integrate into the outer mitochondrial membrane 687708 3.4.22.55 A-549 cell human lung adenocarcinoma cell 665247 3.4.22.55 A2780/CDDP cell - 732733 3.4.22.55 acute T-lymphocytic leukemia cell treatment of melanoma cells with terfenadine induced DNA damage and caspases 2 activation. A selective inhibitor of caspase-2 (benzyloxycarbonyl-VDVAD-fluoromethylketone) protects melanoma cells from terfenadine-induced apoptosis 685967 3.4.22.55 ALVA-31 cell histone deacetylase inhibition leads to decreased protein kinase casein kinase 2 activity, which is followed by caspase-2 activation and partial cleavage of caspase-8 that sensitizes the tumor cell to TRAIL-induced apoptosis 684512 3.4.22.55 astrocytoma cell - 663875