3.4.19.3 adrenal gland orchidectomy increases activity of pyrrolidone carboxypeptidase type I, testosterone replacement returns it to control levels 668870 3.4.19.3 adult - 682806 3.4.19.3 bloodstream form - 667525 3.4.19.3 brain - 667884, 682252, 95278, 95279, 95281, 95282, 95296, 95299, 95300, 95310, 95312, 95314, 95315 3.4.19.3 brain cerebral cortex 95300 3.4.19.3 brain high levels in adenohypophysis 95309 3.4.19.3 brain highest activity in the synaptosomal and myelinic fractions 666460 3.4.19.3 brain in the cortex, activity of soluble PGP I and particulate PGP I decreases 5fold and 4fold, respectively, from the embryo to the adult 682806 3.4.19.3 brain pyroglutamate aminopeptidase II is predominantly localized in neuronal cells 95311 3.4.19.3 brain spinal cord 95314 3.4.19.3 brain synaptosomal fraction 653412 3.4.19.3 colon mucosa 653759 3.4.19.3 embryo - 682806 3.4.19.3 heart high levels of of soluble PGP I activity during the initial moments of development, in the fourth postnatal day activity starts to decrease until adulthood. Activity of the particulate form shows lowest values, during the first 20 days of life a significant decrease takes place, from this moment activity remains constant. No significant changes in activity of the particulate form 682806 3.4.19.3 hippocampus - 682252 3.4.19.3 hypophysis - 95300 3.4.19.3 hypothalamus - 668872, 682252, 95306 3.4.19.3 hypothalamus orchidectomy increases activity of pyrrolidone carboxypeptidase type I, high dose of testosterone returns activity to control levels 668870 3.4.19.3 kidney - 95300 3.4.19.3 kidney highest levels of soluble PGP I in all developmental stages, significant increase until 4 postnatal days, afterwards activity decreases slowly until 15 postnatal days, but subsequently continues to increase until 30 postnatal days. Activity of the particulate form increases until parturition day, until adulthood it remains constant with a small increase after 30 postnatal days 682806 3.4.19.3 liver - 731717, 95277, 95283, 95300, 95313 3.4.19.3 liver activity of soluble PGP I does not change significantly until 20 postnatal days, significant increase between 20-30 postnatal days. Significant decrease in the activity of the particulate form from embryonic day 22 to the fourth postnatal day, until 90 postnatal days activity remains constant 682806 3.4.19.3 lung high activity of soluble PGP I during the first days of development, between 20-30 postnatal days activity decreases significantly 682806 3.4.19.3 macrophage - 680172 3.4.19.3 additional information activity dysregulation at different local and systemic levels may participate in the initiation, promotion and progression of breast cancer induced in rat by N-methyl nitrosourea through the increase of gonadotropin-releasing hormone 668872 3.4.19.3 mucosa from colon 653759 3.4.19.3 ovary - 668872 3.4.19.3 pituitary gland anterior and posterior pituitary 668872 3.4.19.3 pituitary gland no change in pyrrolidone carboxypeptidase type I after orchidectomy, activity increases after administration of testosterone 668870 3.4.19.3 promastigote - 681817 3.4.19.3 renal cortex - 680172 3.4.19.3 renal proximal tubule - 667884 3.4.19.3 retina - 95306, 95309, 95310 3.4.19.3 semen - 708574 3.4.19.3 semen highest level in particulate sperm fraction. Increased activity in necrozoospermia 670862 3.4.19.3 serum - 95289, 95300, 95302 3.4.19.3 skeletal muscle - 95300 3.4.19.3 skeletal muscle quadriceps muscle 95301 3.4.19.3 small intestine pyroglutamyl-peptidase I is not involved in the aetilohy and pathology of coeliac disease 668475 3.4.19.3 submandibular gland - 95298 3.4.19.3 thyroid gland - 668872 3.4.19.3 trypanosomoid form - 667525 3.4.19.3 trypomastigote - 667525