3.4.18.1 alimentary canal - 691910 3.4.18.1 astrocyte - 683448 3.4.18.1 blood plasma - 665927 3.4.18.1 bone marrow cathepsin X can be secreted by nonhematopoietic bone marrow cells in an activated form 708633 3.4.18.1 bone marrow stromal cell - 708633 3.4.18.1 brain - 683448, 691910, 696995 3.4.18.1 brain the enzyme is associated with plaques in Alzheimer patients, overview 683448 3.4.18.1 brain stem - 683448 3.4.18.1 breast cancer cell - 710431 3.4.18.1 BV-2 cell microglial cell 754902 3.4.18.1 CAL-72 cell an osteoblastic cell line 708633 3.4.18.1 central nervous system healthy, aging, and pathological, expression patterns of cathepsin X, overview 683448 3.4.18.1 cerebellum - 683448 3.4.18.1 cerebral cortex - 683448 3.4.18.1 cerebral cortex of healthy individuals and Alzheimer patients 683448 3.4.18.1 dendritic cell - 664854 3.4.18.1 EOC-13.31 cell microglial cell 754902 3.4.18.1 eye - 691910 3.4.18.1 gastric cancer cell - 666147 3.4.18.1 gastric mucosa upregulation in gastric cancer compared to non-neoplastic mucosa. Patients with Helicobacter pylori gastritis show significantly higher cathepsin X mRNA (2.5fold) and protein (1.6fold) expression than Helicobacter pylori-negative partients 666147 3.4.18.1 gill - 691910 3.4.18.1 glial cell - 683448 3.4.18.1 glial cell the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis 683448 3.4.18.1 granulosa cell in oocytes 683378 3.4.18.1 heart - 691910 3.4.18.1 HeLa cell - 684099 3.4.18.1 intestine - 691910 3.4.18.1 JURKAT cell - 683533, 708056 3.4.18.1 KG-1 cell - 683533 3.4.18.1 KG-1 cell a human myeloblast cell line, derived from bone marrow aspirate obtained from male with erythroleukemia that evolved into acute myelogenous leukemia. KG-1 cells differentiate to macrophage like cells, express significant amount of cathepsin X 708748 3.4.18.1 kidney - 691910 3.4.18.1 L87/4 cell a bone marrow stromal cell line 708633 3.4.18.1 L88/5 cell a bone marrow stromal cell line 708633 3.4.18.1 leukocyte - 665927 3.4.18.1 liver - 36443, 651078, 653947, 691910, 732052 3.4.18.1 liver most abundant expression 731157 3.4.18.1 lung - 679023 3.4.18.1 lung protein level of cathespin X does not differ significantly between matched pairs of lung tumor and adjacent lung tissue ontained from patients with lung cancer 664854 3.4.18.1 lung cancer cell protein level of cathespin X does not differ significantly between matched pairs of lung tumor and adjacent lung tissue ontained from patients with lung cancer 664854 3.4.18.1 macrophage - 708023 3.4.18.1 macrophage tumor-associated 679023 3.4.18.1 MCF-7 cell - 753477 3.4.18.1 microglia - 683448 3.4.18.1 Mo-T cell - 683533 3.4.18.1 monocyte - 664854, 708023 3.4.18.1 monocyte in germinal centers of secondary follicles in lymph nodes 664854 3.4.18.1 additional information cathepsin X is a lysosomal cysteine protease, found predominantly in cells of monocyte/macrophage lineage 708023 3.4.18.1 additional information cathepsin X shows marked co-localization with Mac-1 integrin receptor on the plasma membrane of differentiated THP-1 cells primed with Helicobacter pylori antigen of group A of therapy-resistant strains. Priming with Helicobacter pylori antigen of groupB of therapy-susceptible strains results in less extensive co-localization with Mac-1 708373 3.4.18.1 additional information enzyme is found in whole body extracts of metacercariae , newly excysted juveniles and 2 week-old juveniles, but not in 3, 4 week-old juveniles and adult flukes, with presence of cathepsin B2 only in the caecal epithelium of metacercariae, newly excysted juveniles and 2 week-old juveniles 731770 3.4.18.1 additional information no enzyme secretion from hematopoietic stem and progenitor cells, e.g. CD34+ HSPC, G292 cells 708633 3.4.18.1 additional information strongly upregulated in infected gastric mucosa and intestinal-type gastric cancer 693808 3.4.18.1 additional information the cell lines MCF-10A neoT and MDA-MB 231 are negative for cathepsin 664854 3.4.18.1 additional information tissue distribution, immunohistochemic analysis, overview 683448 3.4.18.1 additional information wide tissue distribution of enzyme expression 683378 3.4.18.1 muscle - 691910 3.4.18.1 NCI-N87 cell human gastric epithelial cell 693808 3.4.18.1 neuron - 683448, 696995, 708748 3.4.18.1 oligodendrocyte very low enzyme content 683448 3.4.18.1 oocyte enzyme mRNA accumulation during maturation 683378 3.4.18.1 osteoblast - 708633 3.4.18.1 ovarian cumulus cell cumulus cells surrounding germinal vesicle oocytes harvested from adult versus prepubertal animals, developmental expression profile, overview, the enzyme expression is severalfold higher in prepubertal cells 683222 3.4.18.1 ovarian follicle - 683222 3.4.18.1 PC-12 cell - 732575 3.4.18.1 PC-3 cell human prostate cancer cell 755099 3.4.18.1 PC-3 cell prostate cancer cell 755099 3.4.18.1 pyloric cecum - 691910 3.4.18.1 spinal cord - 683448 3.4.18.1 spinal cord grey and white matter 696995 3.4.18.1 spleen - 36645, 691910 3.4.18.1 stomach - 691910 3.4.18.1 T-cell - 708379 3.4.18.1 T-lymphocyte - 708056 3.4.18.1 THP-1 cell primary 708373 3.4.18.1 U-937 cell - 664854, 664856, 683533 3.4.18.1 U-937 cell monocytic 693808 3.4.18.1 umbilical vein endothelial cell the enzyme accumulates in vesicles at lamellipodia 683638