2.3.1.135 adipose tissue - -, 674449, 674487 2.3.1.135 adrenal gland mRNA expression 638619 2.3.1.135 ARPE-19 cell - 658661 2.3.1.135 Bowman's capsule in the glomeruli of normal, neoplastic kidney sections 658462 2.3.1.135 brain mRNA expression in adult stage 638620 2.3.1.135 breast - 674069 2.3.1.135 breast adenocarcinoma cell breast carcinoma cells have lower LRAT activity 638622 2.3.1.135 breast cancer cell neoplastic and adjacent, non-neoplastic glandular breast tissue specimens from human patients, expression analysis, reduced enzyme expression, LRAT protein progressively decreases with a reduction in the degree of tumor differentiation in invasive breast carcinomas, overview 674069 2.3.1.135 carcinoma cell skin, these cells have lower LRAT activity 638622 2.3.1.135 embryo LRAT acts together with Cyp26A1, one of the enzymes that catalyze the degradation of retinoic acid, and possibly with STRA6, the cell surface receptor for retinol-retinol-binding protein, in maintaining adequate levels of retinoids in embryonic and extraembryonic tissues 687788 2.3.1.135 epithelium of renal tubules 658462 2.3.1.135 epithelium retinal, pigmented 658821, 659309 2.3.1.135 eye - -, 657964, 658662, 674517, 674833, 676112, 719417, 720030, 720353, 758452 2.3.1.135 eye expression in lens and lens epithelium and fibers from embryo to adulthood 736951 2.3.1.135 HaCaT cell - 715720 2.3.1.135 heart - -, 674449 2.3.1.135 hepatic stellate cell - 720839 2.3.1.135 intestinal mucosa - 487491, 638609 2.3.1.135 intestine - 638612, 638614, 638619, 720353 2.3.1.135 keratinocyte - 715720 2.3.1.135 kidney - 658432, 658462, 674487 2.3.1.135 kidney tumor cell - 658462 2.3.1.135 liver - 487491, 638612, 638613, 638619, 638624, 658001, 658432, 658821, 659309, 674487, 674517, 676112, 720353, 720839, 756085 2.3.1.135 liver LRAT and cellular retinol-binding protein CRBP I are well colocalized within the liver lobules of polar bears 758200 2.3.1.135 liver mRNA expression in adult and fetal stage 638617, 638620 2.3.1.135 liver nonparenchymal cells LRAT activity is approximately 10 fold greater than the hepatocyte LRAT activity from both vitamin A-sufficient and retinoid acid treated vitamin A-depleted rats 638616 2.3.1.135 liver the enzyme is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver 688779 2.3.1.135 liver undetectable in vitamin A depleted rats 638614, 638619 2.3.1.135 lung - 674487 2.3.1.135 lung mRNA expression 638619 2.3.1.135 LX-2 cell - 756085 2.3.1.135 Ma-Mel-04 cell - 715720 2.3.1.135 Ma-Mel-11 cell - 715720 2.3.1.135 Ma-Mel-12 cell - 715720 2.3.1.135 mammary gland - -, 487491, 674449 2.3.1.135 melanocyte epidermal 715720 2.3.1.135 melanoma cell diverse cell lines 715720 2.3.1.135 MeWo cell - 715720 2.3.1.135 additional information determination of retinoid levels in liver, blood, and lung of wild-type and knockout mutant mice 659309 2.3.1.135 additional information expression of multiple mRNAs in a tissue-specific manner 658821 2.3.1.135 additional information LRAT is expressed in multiple tissues 719417 2.3.1.135 additional information renal tissue expression pattern, expression is higher in renal tumor than in normal tissue 658462 2.3.1.135 Muller cell primary cell culture 672075 2.3.1.135 muscle - -, 674449 2.3.1.135 pancreas mRNA expression in adult stage 638617, 638620 2.3.1.135 prostate GATA transcription factors are involved in the transcriptional activation of LRAT in normal human prostate epithelial cells 687128 2.3.1.135 prostate mRNA expression 638620 2.3.1.135 prostate practically no activity in prostatic cancer cells 638622 2.3.1.135 prostate cancer cell adenocarcinoma, LRAT is downregulated as a result of oncogenic transformation 638622 2.3.1.135 prostate cancer cell transcriptional regulation of the human LRAT gene is aberrant in human prostate cancer cells 687128 2.3.1.135 renal cell carcinoma cell metastatic 658462 2.3.1.135 renal glomerulus - 658462 2.3.1.135 renal tubule epithelial cells 658462 2.3.1.135 retina - 658001, 672075 2.3.1.135 retina pigmented epithelial cells 658821, 659309 2.3.1.135 retinal pigment epithelium - -, 487491, 638608, 638611, 638615, 638617, 638620, 658662, 674517, 674833, 676112, 719417, 720353 2.3.1.135 retinoblastoma cell - 715720 2.3.1.135 SK-MEL-23 cell - 715720 2.3.1.135 skeletal muscle mRNA expression 638619 2.3.1.135 skin - 715720 2.3.1.135 small intestine - 638609, 638619 2.3.1.135 small intestine mRNA expression 638617, 638620 2.3.1.135 stellate cell hepatic stellate cells shift their retinyl ester synthesizing capacity from LRAT to acyl-CoA:diacylglycerol acyltransferase DGAT1 during activation 756085 2.3.1.135 stellate cell liver 674487 2.3.1.135 testis - 487491, 638619, 658821, 720353 2.3.1.135 testis expression both in Sertoli and in spermatocytes marking initiation of spermatogenesis in prepubertal mice 736951 2.3.1.135 testis mRNA expression 638620 2.3.1.135 UKRV-Mel-27 cell - 715720 2.3.1.135 Y-79 cell - 715720