1.17.4.2 A-549 cell - 685023 1.17.4.2 BALB/3T3 cell fibroblast cell, non-dividing cells expressing enzyme subunit p53R2, but not sunit R2 protein, have reduced dNTP levels if exposed to the enzyme--specific inhibitor hydroxyurea. After DNA damage, a slow, up to 4fold increase in p53R2 expression leads to 3fold increase in dNTP pools in G0/G1 cells 674765 1.17.4.2 colonic cancer cell - 689295 1.17.4.2 fat body significant induction of subunit R2 following blood feeding 673834 1.17.4.2 fibroblast isozymes R2 and p53R2 715583 1.17.4.2 flower subunit R2 isoforms TSO2 and RNR2A 676426 1.17.4.2 HCT-116 cell colon cancer cell. Cell line expresses subunit R2 in excess resulting in protection against DNA damage and replication stress 671925 1.17.4.2 HeLa cell - 746494 1.17.4.2 HL-60 cell - 687180 1.17.4.2 HL-60 cell promyelocytic leukemia cells 672890 1.17.4.2 HT-29 cell - 689295 1.17.4.2 KB cell oropharyngeal epidermal carcinoma cell line. At G1/S phase transition, level of p53-dependent small enzyme subunit M2B increases to maximum levles, and decreases with DNA synthesis. In response to DNA replication, subunit M2B redistributes from the cytoplasm to the nucleus earlier than small subunit M2 671912 1.17.4.2 leaf cauline leaf, subunit R2 isoforms TSO2 and RNR2A 676426 1.17.4.2 meristem - -, 716563 1.17.4.2 additional information exponentialy grown cells predominantly express class I enzyme compared with class II enzyme, activity in stationary phase cells 659464 1.17.4.2 additional information expression of subunit isoform RNR2B in all tissues tested, but at low level 676426 1.17.4.2 additional information RNR expression in small cell lung cancer cell lines, overview 685023 1.17.4.2 additional information RNR2Tso2 is more prevalent than RNR2A throughout development and in most organs, suggesting that RNR2Tso2 is the predominant RNR2 in Arabidopsis thaliana. RNR2Tso2 levels are more varied than RNR2A levels in response to environmental changes and exposure to chemicals -, 716563 1.17.4.2 mycelium - 437895 1.17.4.2 NCI-H292 cell - 685023 1.17.4.2 NCI-H460 cell - 685023 1.17.4.2 ovary higest expression of subunit R2 in ovary of blood-fed or sugar-fed animals. Significant induction following blood feeding 673834 1.17.4.2 promyelocytic leukemia cell - 687180 1.17.4.2 root subunit R2 isoform TSO2 676426 1.17.4.2 rosette subunit R2 isoforms TSO2 and RNR2A 676426 1.17.4.2 stem subunit R2 isoforms TSO2 and RNR2A 676426 1.17.4.2 SW-1573 cell - 685023