1.13.11.20 adipocyte - 695529 1.13.11.20 adipose tissue - 693792, 695529 1.13.11.20 brain - 439557, 657523, 742253 1.13.11.20 brain barely detectable levels 439556 1.13.11.20 brain lower level than in liver 657515 1.13.11.20 brain neuron, including the pyramidal cells of the hippocampus and the Purkinje cells of the cerebellum, the regional localization varies, with high levels of expression in the hippocampus, the dentate gyrus, the outer cortices of the brain, and the substantia nigra 439555 1.13.11.20 colonic cancer cell - 765832 1.13.11.20 epididymis androgen-dependent CDO expression is highest in the caput epididymidis 764652 1.13.11.20 epithelium - 764939 1.13.11.20 Hep-G2 cell hepatoblastoma cells, enzyme expression is up-regulated under hypertonic conditions 657832 1.13.11.20 hepatocyte - 695529 1.13.11.20 hepatocyte primary cell culture 659767 1.13.11.20 hepatocyte primary cell culture, high enzyme activity in cysteine rich medium 657515 1.13.11.20 intestinal epithelium CDO is found specifically in the mucus-secreting goblet cells 695529 1.13.11.20 keratinocyte - 725864 1.13.11.20 kidney - 742253 1.13.11.20 kidney easily detectable levels 439556 1.13.11.20 kidney lower level than in liver 657515 1.13.11.20 liver - 439541, 439542, 439544, 439545, 439546, 439547, 439548, 439549, 439550, 439551, 439552, 439553, 439554, 439557, 657515, 657523, 657832, 659767, 674569, 693792, 695529, 765261 1.13.11.20 liver cDNA 676962 1.13.11.20 liver highest level of mRNA detected 439556 1.13.11.20 liver lack of methionine sulfoxide reductase MsrA in liver of MsrA -/- mice leads to a significant drop in the cellular level of thiol groups and lowers the level of cysteine dioxygenase expression. Following selenium deficient diet applied to decrease the expression levels of selenoproteins like MsrB, the latter effect is maintained while the basal levels of thiol decreased in both wild-type strains and strains deficient for methionine dioxygenase 684830 1.13.11.20 liver mainly 742253 1.13.11.20 lung - 657523, 742253 1.13.11.20 lung alveolar epithelial cells, no enzyme detected in smooth muscle cells lining the alveoli or in blood vessels within the surrounding tissue 659966 1.13.11.20 lung easily detectable levels 439556 1.13.11.20 lung lower level than in liver 657515 1.13.11.20 mammary gland - 764939 1.13.11.20 mammary gland intense staining for CDO in ductal cells of pregnant rats but not in other mammary epithelial cells or in ductal cells of non-pregnant rats 695529 1.13.11.20 additional information distribution is found to be centrilobular and does not alter when the enzyme is induced with cysteine or methionine 439553 1.13.11.20 additional information in Bacillus and Streptomyces spp. CDO is expressed in the vegetative state, and an increase in its activity is detected after the initiation of conidia production 725864 1.13.11.20 additional information no activity in mycelium 439543 1.13.11.20 additional information no enzyme message observed in the spleen, heart or skeletal muscle 439556 1.13.11.20 mycelium in Streptomyces spp. CDO is expressed in the vegetative state, and an increase in its activity is detected after the initiation of conidia production 725864 1.13.11.20 pancreas exocrine cell, but not in islet endocrine cells 695529 1.13.11.20 skin - 725864 1.13.11.20 small intestine detectable levels 439556 1.13.11.20 testis barely detectable levels 439556 1.13.11.20 U2-OS cell - 765832