3.1.27.8	evolution	the enzyme preserves the general RNase H-like structure, especially in the wedge motif, the metal-binding site and the hypoxanthine-binding pocket. The human enzyme also features several extra insertions and a characteristic four cysteine motif, in which Cys227 and Cys228, two cysteines that are highly conserved in higher eukaryotes, play important roles in catalysis	728877	
3.1.27.8	additional information	structure analysis and substrate-recognition mechanism, overview	728877