3.1.25.1	additional information	treatment of Cdk4R24C/R24C/NrasQ61K mice topically with the T4 endonuclease V DNA repair enzyme immediately prior to neonatal ultraviolet radiation exposure has a powerful effect in exacerbating melanoma development in the mouse model, overview. Dimericine reduces the incidence of basal-cell and squamous cell carcinoma. No difference in penetrance or age of onset of melanoma after neonatal UVR between Dimericine-treated and control animals, although the drug reduces DNA damage and cellular proliferation in the skin. Proliferation of melanocytes is inhibited by Dimericine treatment and reduces the level of DNA damage following UVR exposure	710256	
3.1.25.1	physiological function	the T4 endonuclease V is a DNA repair enzyme	710256