2.3.1.B38	malfunction	effects of QS inhibitors (QSIs), such as MvfR antagonists and PqsBC inhibitors, on the biosynthesis of the MvfR-regulated small molecules 2'-aminoacetophenone (2-AA), dihydroxyquinoline (DHQ), 4-hydroxy-2-heptylquinoline (HHQ), Pseudomonas quinolone signal (PQS), and 4-hydroxy-2-heptylquinoline-N-oxide (HQNO)	-, 756793	
2.3.1.B38	metabolism	the 2-heptyl-4(1H)-quinolone synthase is involved in the biosynthetic pathway of MvfR-related small molecules. In-depth profiling of MvfR-regulated small molecules in Pseudomonas aeruginosa after quorum sensing inhibitor treatment	-, 756793	
2.3.1.B38	physiological function	4-hydroxy-2-alkylquinoline biosynthesis, which requires the PqsABCD enzymes, proceeds by a two-step pathway: PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-coenzyme A and malonyl-coenzyme A, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of 3,4-dihydroxy-2-heptylquinoline. PqsB is tightly associated with PqsC and required for the second step. None of the pqsA-, pqsB-, pqsC-, and pqs- mutants produces measurable amounts of 4-hydroxy-2-alkylquinolines, and PqsB and PqsC have to be present simultaneously to transform the intermediate into 4-hydroxy-2-heptylquinoline	-, 735925