5.1.3.37	evolution	Ectocarpus contains a multigenic family of putative ManC5-Es. The genome sequence of Ectocarpus offers the opportunity to have access to a higher number of genes, and potentially proteins, 31 putative ManC5-E genes are analyzed. The ManC5-E family includes genes that are differentially regulated during the life cycle of Ectocarpus	747915	
5.1.3.37	evolution	the bacterium Azotobacter vinelandii produces a family of seven secreted and calcium-dependent mannuronan C-5 epimerases (AlgE1-7)	748180	
5.1.3.37	malfunction	reducing the size of AlgE6 influences the epimerization of modified alginates in solution. The A-module from AlgE6 seems to be more affected than AlgE64 at higher degree of oxidation	747457	
5.1.3.37	metabolism	biosynthetic pathway of alginate and the alginate structure involving the enzyme, overview	746698	
5.1.3.37	additional information	alginate epimerases consist of catalytic and noncatalytic domains. The noncatalytic domains of AlgE4 and AlgE6 possess different alginate binding behavior despite highly similar structures. Noncatalytic subunits of AlgE6 and AlgE4 influence the product specificity of the catalytic domain	748180	
5.1.3.37	additional information	the A-module is the minimal size for an active epimerase even though the active site is located in proximity of the N-terminus	747457	
5.1.3.37	additional information	the A-module is the minimal size for an active epimerase even though the active site is located in proximity of the N-terminus. AlgE1 is larger than AlgE6 and has two catalytic active modules (A1 and A2)	747457	
5.1.3.37	additional information	transcript expression as a function of the developmental program of the brown alga, Ectocarpus sp.	747915	
5.1.3.37	physiological function	alginate is produced as poly-M and then certain M residues are converted to G by epimerases acting on the polymer level. The alginate-producing bacterium Azotobacter vinelandii has one periplasmic epimerase, which incorporates single G residues into the alginate during secretion of the polymer. In addition, Azotobacter vinelandii produces seven extracellular C-5 alginate epimerases called AlgE1-7. Each of the epimerases convert mannuronic acid to guluronic acid in different patterns. The secreted and calcium-dependent mannuronan C-5 epimerases in Azotobacter vinelandii are responsible for epimerization of beta-D-mannuronic acid (M) to alpha-L-guluronic acid (G) in alginate polymers	748180	
5.1.3.37	physiological function	alginate is produced as poly-M and then certain M residues are converted to G by epimerases acting on the polymer level. The alginate-producing bacterium Azotobacter vinelandii has one periplasmic epimerase, which incorporates single G residues into the alginate during secretion of the polymer. In addition, Azotobacter vinelandii produces seven extracellular C-5 alginate epimerases called AlgE1-7. Each of the epimerases converts mannuronic acid to guluronic acid in different patterns. The secreted and calcium-dependent mannuronan C-5 epimerases in Azotobacter vinelandii are responsible for epimerization of beta-D-mannuronic acid (M) to alpha-L-guluronic acid (G) in alginate polymers	748180