3.4.22.43	malfunction	increased cathepsin V promoted the degradation of DUSP6 and DUSP7, phosphorylation and subsequent nuclear translocation of ERK1/2, phosphorylation of STAT1 and expression of interleukin (IL)-6, IL-8 and TNF-alpha	753117	
3.4.22.43	malfunction	lack of cathepsins prevent the development of lung granulomas in a mouse model of Besnier-Boeck-Schaumann (BBS) disease, sarcoidosis. Cathepsin V (Cath V) in bronchoalveolar lavage fluid (BALF) in humans	752418	
3.4.22.43	malfunction	melanosome degradation is suppressed in CTSV knockdown cells. Inhibition of CTSV expression increases melanosome accumulation in HaCaT keratinocytes. The rate of melanosome degradation is reduced in CTSV knockdown keratinocytes	752678	
3.4.22.43	malfunction	RNAi-mediated depletion of the enzyme effectively abrogates ectopic E2F1-induced apoptosis, coupled with reduced lysosomal membrane permeabilization and mitochondrial membrane depolarization. Enzyme knockdown also inhibits apoptosis mediated by the endogenous E2F1 activated by DNA damage. Enzyme depletion in cancer cells results in inhibition of histone deacetylase inhibitor-induced apoptosis	732591	
3.4.22.43	metabolism	cathepsin V and endostatin may represent an index of pulmonary sarcoidosis activity	752418	
3.4.22.43	metabolism	cathepsin V participates in the production of enkephalin and neuropeptide Y neurotransmitters in secretory vesicles	732049	
3.4.22.43	metabolism	effects of cathepsin V on the dual-specificity protein phosphatases (DUSPs) and MAPK pathways	753117	
3.4.22.43	physiological function	cathepsin like 2 is required for E2F1-induced apoptosis by engaging lysosomal membrane permeabilization. Its level also modulates the cellular sensitivity to histone deacetylase inhibitor	732591	
3.4.22.43	physiological function	CTSV is involved in the breakdown of corneodesmosomal proteins	709405	
3.4.22.43	physiological function	enzyme cathepsin V (CTSV) is involved in melanosome degradation in the keratinocytes derived from lightcolored skin. It is one of the factors regulating pigmentation	752678