3.4.22.10	malfunction	wild type strain efficiently translocates across the epithelial monolayer along with cleavage of occludin and E-cadherin. Deletion of the speB gene compromises those activities. Destabilization of the junctional proteins is relieved in cells infected with the speB mutant, as compared with those infected with the wild type	734212	
3.4.22.10	metabolism	the endopeptidase PepO is a growth phase dependent regulator of SpeB in the invasive GAS M1 serotype strain 5448. PepO influences growth phase-dependent induction of speB gene expression	-, 754018	
3.4.22.10	physiological function	addition of SpeB to human plasma increases plasma-mediated bacterial killing and prolonged coagulation time through the intrinsic pathway of coagulation. This effect is independent of the enzymatic activity of SpeB and is mediated by a noncovalent medium-affinity binding and modification of alpha-1 antitrypsin	-, 717218	
3.4.22.10	physiological function	in infected mice, SpyCEP expression by Streptococcus pyogenes hinders bacterial clearance from muscle, and enhances bacterial spread, associated with cleavage of CXCL1. SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues. SpyCEP enhances Streptococcus pyogenes dissemination to lower respiratory tract from nasopharynx	-, 718127	
3.4.22.10	physiological function	streptopain is a critical virulence factor for pathogenesis	755296	
3.4.22.10	physiological function	the streptococcal regulator of virulence control of SpeB production is a mechanism to regulate biofilm dispersal and provides a mechanism by which mild infection can transition to severe disease	-, 718299