3.4.17.12	physiological function	both microRNA-146a-5p and carboxypeptidase M regulate Src and FAK expression, while the Src-FAK signaling pathway is associated with the migration and invasion of multiple tumor cells. The functional and mechanistic relationship of the miR-146a-5p/CPM/Src-FAK axis is demonstrated and its effect on the migration and invasion of colorectal cancer cells	754960	
3.4.17.12	physiological function	in HEK-293 cells stably transfected with kinin B1 receptor, co-expression of carboxypeptidase M enhances des-Arg10-kallidin-stimulated increases in intracellular Ca2+ or phosphoinositide turnover. Carboxypeptidase M increases kinin B1 receptor affinity for des-Arg10-kallidin by 5-fold but has no effect on basal kinin B1 receptor-dependent phosphoinositide turnover. Soluble, recombinant carboxypeptidase M binds to HEK cells expressing kinin B1 receptor without stimulating receptor signaling. Carboxypeptidase M positive allosteric action is independent of enzyme activity but depended on interaction of its C-terminal domain with the kinin B1 receptor extracellular loop 2. Disruption of the carboxypeptidase M/kinin B1 receptor interaction or knockdown of carboxypeptidase M in cytokine-treated primary human endothelial cells inhibits the allosteric enhancement of carboxypeptidase M on kinin B1 receptor des-Arg10-kallidin binding or ERK1/2 activation. Carboxypeptidase M also enhances the des-Arg10-kallidin-induced kinin B1 receptor conformational changes	732121