2.3.1.191	malfunction	enzyme activity of the temperature-sensitive firA mutant RL-25 is reduced to less than 10% of wild-type enzyme	698693	
2.3.1.191	malfunction	lpxD mutant is susceptible to vancomycin and teicoplanin	695627	
2.3.1.191	malfunction	lpxD1-null mutant with shorter acyl chains in lipid A is more sensitive to various environmental stresses than Francisella novicida and lpxD2-null mutant	757609	
2.3.1.191	malfunction	the lpxD1-null mutant is attenuated in C57BL/6 mice and subsequently exhibits protection against a lethal wild-type challenge. The lpxD1-null and lpxD2-null mutant strains show altered antibiotic susceptibility patterns, membrane permeability, but no innate immune responses. The DELTAlpxD1 mutant is more susceptible to antibiotics with diverse mechanisms of action such as chloramphenicol, carbenicillin, ciprofloxacin, erythromycin, rifampin, and vancomycin, whereas the DELTAlpxD2 mutant is only susceptible to carbenicillin and erythromycin	-, 720944	
2.3.1.191	metabolism	Francisella modifies its lipid A structure in response to temperature adaptation by altering the length of the amidelinked acyl chains: 3-OH-C16 at environmental temperature and 3-OH-C18 at mammalian temperature	-, 720944	
2.3.1.191	metabolism	LpxD catalyzes the third step of lipid A biosynthesis, an acyl-acyl carrier protein (ACP)-dependent transfer of a fatty acyl moiety to a UDP-glucosamine core ring, overview	718571	
2.3.1.191	metabolism	quantitative model of the nine enzyme-catalyzed steps of Escherichia coli lipid A biosynthesis. Biosynthesis regulation occurs through regulated degradation of the LpxC and WaaA enzymes. LpxC, EC 3.5.1.108, is the rate-limiting enzyme if pathway regulation is ignored, but LpxK, EC 2.7.1.130, is the rate-limiting enzyme if pathway regulation is present, as it is in real cells	737072	
2.3.1.191	metabolism	the enzyme is involved in lipid A biosynthesis	757609	
2.3.1.191	metabolism	the enzyme is involved in lipid A biosynthesis in Gram-negative bacteria	755699	
2.3.1.191	metabolism	the enzyme is involved in the lipid A biosynthesis in the plant	-, 720913