2.1.1.311	malfunction	deletion of Rcm1 specifically abolishes the methylation of m5C 2278 in the 25S rRNA. The loss of m5C2278 results in anisomycin hypersensitivity. The deletion of rcm1 does not result in any significant growth defect at 30 and 37°C. Deletion of rcm1 does not disturb the 60S stoichiometry and polysome assembly	-, 730499	
2.1.1.311	malfunction	loss of Rcm1 alters the structural conformation of the ribosome in close proximity to C2278, as well as translational fidelity, and favours recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes	-, 730447	
2.1.1.311	physiological function	the methylated residues m5C2278 stabilizes the structure of 25S rRNA and consequently the association of ribosomal proteins with the large ribosomal subunit	-, 730941