1.6.1.3 malfunction mice lacking functional enzyme are characterized by lower energy expenditure rates, consistent with their well-known susceptibility to diet-induced obesity 741856 1.6.1.3 physiological function the activity of NAD(P) transhydrogenase is a key element in determining the redox state of NADP and thus of Ca2+ retention and efflux from mitochondria 724104 1.6.1.3 physiological function the enzyme of adult Hymenolepis diminuta physiologically couples matrix-localized, NADP-specific malic enzyme with NADH-dependent anaerobic electron transport. The enzyme acts in the translocation of protons from the matrix to the intermembrane space mitochondrial compartment 724928