1.3.1.85 metabolism crotonyl-CoA carboxylase/reductase is the key enzyme of the ethylmalonyl-CoA pathway 689745 1.3.1.85 metabolism the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway 710982 1.3.1.85 physiological function crotonyl-CoA carboxylase/reductase, a key enzyme of the ethylmalonyl-CoA pathway for acetyl-CoA assimilation, is not essential for growth with 3-hydroxypropionate 725270