1.17.1.3	evolution	enzyme LAR is related to members of the reductase-epimerase-dehydrogenase protein superfamily	746103	
1.17.1.3	evolution	enzyme LAR3 belongs to the short-chain dehydrogenase/reductase protein family	746116	
1.17.1.3	evolution	phylogenetic analysis of the LAR family, overview	746163	
1.17.1.3	evolution	phylogenetic analysis of the LAR family, overview. The dicotyledonous LARs can be clustered into two subgroups, which are defined as cluster I and cluster II	746163	
1.17.1.3	malfunction	ectopic expression of PtrLAR1 in poplar positively regulates the biosynthesis of proanthocyanidin, whereas the accumulation of anthocyanin and flavonol is significantly reduced in all transgenic plants compared to the control plants	726337	
1.17.1.3	malfunction	overexpression of CsLAR causes a decrease in the proanthocyanidins in transgenic plants	746163	
1.17.1.3	malfunction	overexpression of PtrLAR3 in Chinese white poplar (Populus tomentosa Carr.) leads to a significant plant-wide increase in proanthocyanidin levels. In vitro assays show that crude leaf extracts from 35S:PtrLAR3 transformants are able to inhibit significantly the hyphal growth of Marssonina brunnea f.sp.multigerm tubi compared to the extracts from control plants. The transgenic 35S:PtrLAR3 poplar plants display a significant reduction in their disease symptoms compared with the control	728054	
1.17.1.3	malfunction	transgenic tobacco overexpressing TcLAR have decreased amounts of anthocyanidins and increased proanthocyanidins. Overexpressing TcLAR in Arabidopsis ldox mutant also results in elevated synthesis of not only catechin but also epicatechin	727256	
1.17.1.3	metabolism	flavan-3-ols are synthesized through the flavonoid pathway via leucoanthocyanidin and anthocyanidin. Leucoanthocyanidin can be converted to (+)-flavan-3-ol, e.g. (+)-catechin, by leucoanthocyanidin reductase (LAR) or to anthocyanidin by anthocyanidin synthase (ANS)	-, 745869	
1.17.1.3	metabolism	leucoanthocyanidin reductase and anthocyanidin reductase are involved in biosynthesis of proanthocyanidins or condensed tannins by producing (+)-catechin and (-)-epicatechin, respectively, from leukoanthocyanidin	716027