1.14.18.5	physiological function	the enzyme plays an essential role in phytosphingolipid synthesis in human skin and other phytosphingolipid-containing tissues	719485	
1.14.18.5	physiological function	sphingolipid C4 hydroxylation by the enzyme influences properties of detergent-insoluble glycolipid-enriched membranes	719486	
1.14.18.5	malfunction	deleting the SUR2 gene reduces hydroxylation of ceramides and suppresses Ca2+ sensitivity of csg2 mutants	719792	
1.14.18.5	physiological function	Sur2p is required for the hydroxylation of C-4 of the sphingoid moiety of ceramide. The enzyme is not essential for growth	719792	
1.14.18.5	malfunction	yeast strains deficient in Syr2 lack the sphingoid long chain base phytosphingosine	-, 719795	
1.14.18.5	physiological function	SYR2 is necessary for growth inhibition by the cyclic lipodepsipeptide syringomycin E. The SYR2 gene is required for the 4-hydroxylation reaction of sphingolipid long chain bases and is not essential for growth. SYR2 does not play a role in sterol biosynthesis	-, 719795	
1.14.18.5	physiological function	C-4 hydroxylation of sphingolipids is important for the antifungal action of syringomycin E. Mutants with defects in C-4 hydroxylated sphingoid base biosynthesis are resistant to this antifungal agent	733375