1.14.14.29	metabolism	CYP7B1 is an enzyme expressed in many human tissues and implicated in cholesterol metabolism. In the liver, this protein is part of the alternate/acidic pathway for primary bile acid production while in brain, CYP7B1 provides the primary metabolic route for cholesterol derivatives dehydroepiandrosterone and related hydroxysteroids via 7alpha-hydroxylation	711775	
1.14.14.29	additional information	spastic paraplegia type 5, SPG5, is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-alpha-hydroxylase, CYP7B1, an enzyme implicated in cholesterol metabolism. Mutations in CYP7B1 are found in both pure and complicated forms of the disease, clinical phenotypes, overview	711775	
1.14.14.29	physiological function	activity towards 5alpha-androstane-3alpha,17beta-diol is very low or undetectable in livers of Cyp7b1(-/-) knockout mice. CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens	702427	
1.14.14.29	physiological function	CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens	702427	
1.14.14.29	physiological function	important role for CYP7B1 in cellular growth, particularly in connection with estrogenic signalling	705397	
1.14.14.29	physiological function	key enzyme in bile acid synthesis by the alternative pathway	695480	
1.14.14.29	physiological function	pregnane X receptor activation significantly regulates genes in the liver involved in lipoprotein transportation and cholesterol metabolism, including CYP39A1, in both wild-type and ApoE-/- mice	705003